The purpose of the research is to investigate the unique solvability of a nonlocal boundary value problem for a loaded equation of parabolic-hyperbolic type in a special domain. Methods: Using representations of a general regular solution, the existence and uniqueness of the problem posed is proved. Results: A new method for proving the unique solvability of nonlocal boundary value problems for one loaded equation of mixed type in a special domain has been formed and developed. Conclusions: The obtained results make it possible to solve some problems of genetics, immunology, transonic gas dynamics and thermal physics, which are associated with displacement.