Transient gestational hypothyroxinemia accelerates and enhances ulcerative colitis-like disorder in the male offspring
Juan Carlos Rivera,
Ma. Cecilia Opazo,
Rosario Hernández-Armengol
et al.
Abstract:IntroductionGestational hypothyroxinemia (HTX) is a condition that occurs frequently at the beginning of pregnancy, and it correlates with cognitive impairment, autism, and attentional deficit in the offspring. Evidence in animal models suggests that gestational HTX can increase the susceptibility of the offspring to develop strong inflammation in immune-mediated inflammatory diseases. Ulcerative colitis (UC) is a frequent inflammatory bowel disease with unknown causes. Therefore, the intensity of ulcerative c… Show more
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