Transient exposure to elastase induces mouse aortic wall smooth muscle cell production of MCP-1 and RANTES during development of experimental aortic aneurysm

Abstract

Increased mouse aortic wall expression of MCP-1 and RANTES occurs early in development of elastase-induced AAA and before onset of the chronic inflammatory response. Moreover, elastase directly stimulates AoSMC chemokine production in vitro. Elastase-induced medial SMC production of CC chemokines may therefore provide an important link between enzymatic injury, leukocyte recruitment, and aneurysmal degeneration of the aortic wall.

Impact of Monocyte Chemoattractant Protein-1 Deficiency on Cerebral Aneurysm Formation

“…MCP-1 was highly expressed in human AAA samples 10 and experimentally induced AAA model in mice. 27 Its receptor, C-C chemokine receptor 2, plays a crucial role in angiotensin II-induced development of AAA formation in mice. 12 The decreased incidence of early aneurysmal changes in MCP-1 -/-mice strongly suggests that MCP-1 also contributes to the initiation of CA formation.…”

Mast cells modulate the pathogenesis of elastase-induced abdominal aortic aneurysms in mice

“…In contrast, elastase perfusion enhanced mast cell numbers in the aortas. One possible explanation is that elastase perfusion induces aortic wall SMC expression of chemokines MCP-1 and RANTES (49), which may attract mast cells (50). Further, elastase perfusion may generate elastin degradation products that signal fibroblast, monocyte, and macrophage chemotaxis (51).…”

Pretreatment with Lornoxicam, a Cyclooxygenase Inhibitor, Relieves Postoperative Immuno-Suppression after Total Abdominal Hysterectomy

“…RANTES is thought to be released by activated T lymphocytes and monocytes/macrophages, epithelial cells, bronchial epithelium, and dermal fibroblast and renal tubular epithelium. It has been demonstrated that RANTES plays an important role in a variety of disease states, including allergic inflammatory processes such as asthma, allergic rhinitis, and atopic dermatitis (Colonnello et al 2003). Niwa et al (2001) have found that plasma RANTES levels are significantly increased in the patients with severe, treatment-resistant atopic dermatitis.…”