Transient Exposure to Coffee as a Trigger of a First Nonfatal Myocardial Infarction

Baylin, Ana; Hernández–Dı́az, Sonia; Kabagambe, Edmond K.; Siles, Xinia; Campos, Hannia

doi:10.1097/01.ede.0000229444.55718.96

Cited by 94 publications

(69 citation statements)

References 30 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Bylin et al reported the chance for by AMI 1.1 folds with drinking coffee (22), and since the type of drink differs between this study and in the one by Bylin, no similarity could be mentioned between these two studies.…”

Section: Discussioncontrasting

confidence: 51%

The Emotional, Environmental, Physical and Chemical Triggers of Acute Myocardial Infarction: An Analytical Demographic Study

Pourshaikhian

Moghadamnia

Ghiasmand

2017

GMJ

View full text Add to dashboard Cite

Objective: Acute triggers are external stimuli that produce acute pathophysiologic changes directly leading to the onset of myocardial infarction (MI). Acute myocardial infarction (AMI) is one of the main causes of mortality. Recent studies have confirmed the impact of acute triggers on the occurrence of AMI, but have not evaluated their differences in terms of demographic characteristics. This study was conducted to investigate the impact of acute triggers on AMI in various demographic groups. Methods: This is an analytical cross-sectional study on 269 patients affected by AMI in two hospitals in 2015 and 2016 in Iran. To attain the goals of the study, acute triggers were divided into four groups of emotional, environmental, physical, and chemical. A researcher-developed questionnaire and interview were used to collect data. The risk and control periods were also evaluated for each trigger. The data were analyzed by descriptive statistics and inferential statistics such as statistical logistic regression and McNemar's test using SPSS 21. The P-value was set at 0.05. Results:The results showed that sudden exposure to hot/cold weather in men (P=0.03, OR=3.4), underlying diseases (P=0.03, OR=1.8), heavy activities (P=0.03, OR=1.6) and consuming tea/coffee in men (P=0.01, OR=1.8) increased the chance of AMI. It was also discovered that triggers such as pulmonary infections, overeating and/or eating high-fat foods that are not dependent on demographic variables promoted the chance of AMI (P<0.05). Conclusion: All people -regardless of age, sex, and the presence/lack of underlying illness -are at risk of developing MI in the face of respiratory infections, overeating, and intake of high-fat foods. Also, sudden exposure to hot and / or cold weather, heavy activity and high consumption of coffee and/or tea, can increase the risk of MI in men. Bulgular: Sonuçlar, erkeklerde sıcak/soğuk havaya ani maruziyetin (P = 0.03, OR = 3.4), altta yatan hastalıkların (P = 0.03, OR = 1.8), ağır aktivitelerin (P = 0.03, OR = 1.6) ve erkeklerde tüketilen çay/kahve (P = 0.01, OR = 1.8) akut kalp krizi riskini artırığını gösterdi. Pulmoner enfeksiyonlar, aşırı yeme ve/veya aşırı yağlı gıdalarla yeme gibi demografik değişkenlere bağımlı olmayan tetikleyicilerin akut kalp krizi riskini arttırdığı da keşfedildi (P <0.05). Sonuç: Yaş, cinsiyet ve altta yatan hastalığın varlığı/eksikliği ne olursa olsun tüm insanlar solunum yolu enfeksiyonları, aşırı yorulma ve yüksek yağlı gıdalar alımı karşısında kalp krizi gelişme riski altındadır. Ayrıca, ani sıcak ve/veya soğuk havaya maruz kalma, yoğun aktivite ve yüksek kahve ve/veya çay tüketimi erkeklerde lap krizi riskini artırabilir.

show abstract

Section: Discussioncontrasting

confidence: 51%

The Emotional, Environmental, Physical and Chemical Triggers of Acute Myocardial Infarction: An Analytical Demographic Study

Pourshaikhian

Moghadamnia

Ghiasmand

2017

GMJ

View full text Add to dashboard Cite

show abstract

“…Interestingly, the effect of caffeine on NFκB activation occurred only under inflammatory or prothrombotic conditions which supports the interpretation that caffeine requires additional stimuli to display its full effect on TF. Since caffeine consumption has been linked to an increased risk of cardiovascular events in some, but not all prospective studies (6,8,9), with some results supporting no association between coffee intake and cardiovascular disease (39) or even beneficial effects of caffeine on cardiovascular morbidity and mortality (7), this mechanism of action may explain, at least to some extent, the ongoing controversy.…”

Section: Discussionmentioning

confidence: 99%

“…Caffeine is often regarded as a cardiovascular risk factor; however, there is conflicting epidemiological evidence on the relation of caffeine consumption to the occurrence of acute cardiovascular events (6)(7)(8)(9)(10)(11)(12)(13). The conflicting evidence may in part be due to the various pleiotropic effects caffeine has on cells at physiologically achievable concentrations.…”

Section: Introductionmentioning

confidence: 99%

Caffeine induces endothelial tissue factor expression via phosphatidylinositol 3-kinase inhibition

Gebhard¹,

Holy²,

Camici³

et al. 2012

Thromb Haemost

View full text Add to dashboard Cite

SummaryTissue factor (TF) is the key activator of coagulation and is involved in acute coronary syndromes. Caffeine is often reported to increase cardiovascular risk; however, its effect on cardiovascular morbidity and mortality is controversial. Hence, this study was designed to investigate the impact of caffeine on endothelial TF expression in vitro. Caffeine concentration-dependently enhanced TF protein expression and surface activity in human endothelial cells stimulated by tumour necrosis factor (TNF)-α or thrombin. Caffeine inhibited phosphatidylinositol 3-kinase (PI3K) activity and this effect was comparable to that of the known PI3K inhibitor LY294002. Consistently, treatment of endothelial cells with LY294002 enhanced TNF-α induced TF expression to a similar extent as caffeine, and adenoviral expression of the active PI3K mutant (p110) reversed the effect of both caffeine and LY294002 on TF expression. Caffeine and LY294002 increased DNA binding capacity of the transcription factor nuclear factor κB, whereas the activation pattern of mitogen-activated protein kinases (MAPK) remained unaltered. Luciferase reporter assay revealed a caffeine dependent activation of the TF promoter, and RT-PCR revealed a dose dependent increase in TF mRNA levels when stimulated with caffeine in the presence of TNF-α. In conclusion, caffeine enhances TNF-α-induced endothelial TF protein expression as well as surface activity by inhibition of PI3K signalling. Since the caffeine concentrations applied in the present study are within the plasma range measured in humans, our findings indicate that caffeine enhances the prothrombotic potential of endothelial cells and underscore the importance of PI3K in mediating these effects.

show abstract

“…26,27 Coffee has been identified as a major source of antioxidants, but on the other hand it is supposed to have adverse effects on blood cholesterol and homocysteine levels and hypertension. [28][29][30][31] Caffeine (1,3,7-trimethylxanthine) is the most important and well-known pharmacologic compound of it, acting as a competitive inhibitor of cyclic nucleotide phosphodiesterase isoenzymes and exerting various functions including the modulation of glucose metabolism, alterations in apoptotic processes, immunomodulatory effects, and stimulation of muscle contraction. 9 Acute and chronic coffee intake is associated with increased arterial stiffness and wave reflections in healthy subjects and in hypertensive ones.…”

Section: Discussionmentioning

confidence: 99%

Consumption of a boiled Greek type of coffee is associated with improved endothelial function: The Ikaria Study

et al. 2013

View full text Add to dashboard Cite

Objective: The association of coffee consumption with cardiovascular disease remains controversial. Endothelial function is associated with cardiovascular risk. We examined the association between chronic coffee consumption and endothelium function in elderly inhabitants of the island of Ikaria. Methods: The analysis was conducted on 142 elderly subjects (aged 66-91 years) of the Ikaria Study. Endothelial function was evaluated by ultrasound measurement of flow-mediated dilation (FMD). Coffee consumption was evaluated based on a food frequency questionnaire and was categorized as 'low' (< 200 ml/day), 'moderate' (200-450 ml/day), or 'high' (> 450 ml/day). Results: From the subjects included in the study, 87% consumed a boiled Greek type of coffee. Moreover, 40% had a 'low', 48% a 'moderate' and 13% a 'high' daily coffee consumption. There was a linear increase in FMD according to coffee consumption ('low': 4.33 ± 2.51% vs 'moderate': 5.39 ± 3.09% vs 'high': 6.47 ± 2.72%; p = 0.032). Moreover, subjects consuming mainly a boiled Greek type of coffee had a significantly higher FMD compared with those consuming other types of coffee beverages (p = 0.035). Conclusions: Chronic coffee consumption is associated with improved endothelial function in elderly subjects, providing a new connection between nutrition and vascular health.

show abstract

Transient Exposure to Coffee as a Trigger of a First Nonfatal Myocardial Infarction

Abstract: The findings indicate that coffee intake may trigger myocardial infarction. The association is particularly strong among people with light/occasional intake of coffee (< or =1 cup/day), with sedentary lifestyle, or with 3 or more risk factors for coronary heart disease.

Cited by 94 publications

References 30 publications

The Emotional, Environmental, Physical and Chemical Triggers of Acute Myocardial Infarction: An Analytical Demographic Study

The Emotional, Environmental, Physical and Chemical Triggers of Acute Myocardial Infarction: An Analytical Demographic Study

Caffeine induces endothelial tissue factor expression via phosphatidylinositol 3-kinase inhibition

Consumption of a boiled Greek type of coffee is associated with improved endothelial function: The Ikaria Study

Contact Info

Product

Resources

About