Transient Evoked Otoacoustic Emissions in Laboratory Animals

Khvoles, Roza; Freeman, Sharon; Sohmer, Haim

doi:10.3109/00206099909073013

Cited by 13 publications

(9 citation statements)

References 16 publications

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“…Small but significant changes in the characteristics of otoacoustic emissions may serve as an indicator of outer hair cell subclinical or clinical pathology. The influence of the status of the cochlea on DPOAE properties has been discussed for rabbits [10,11,12], and it was demonstrated that a level of hearing loss of the subject examined equal to or greater than 30 dB can be considered sufficient to suppress the evoked response.…”

Section: Introductionmentioning

confidence: 99%

Effects of microwaves (900 MHz) on the cochlear receptor: exposure systems and preliminary results

Marino¹,

Cristalli

Galloni³

et al. 2000

Radiation and Environmental Biophysics

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The purpose of this paper is to present the experimental device and the work in progress performed in search for objective organic correlation of damage to hearing, examining possible acoustic otofunctional effects on the cochlear epithelium of the rat due to exposure to microwaves (900 MHz). Two experiments using male Sprague-Dawley rats were carried out with a far-field exposure in a cubic chamber. No statistically significant evidence was obtained at both specific absorption rate (SAR) values. The exposure system and the diagnostic apparatus are extremely useful to investigate a potential effect on the auditory system: however, with the parameters applied in these experiments, no evidence was observed.

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Section: Introductionmentioning

confidence: 99%

Effects of microwaves (900 MHz) on the cochlear receptor: exposure systems and preliminary results

Marino¹,

Cristalli

Galloni³

et al. 2000

Radiation and Environmental Biophysics

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“…Both the response and the noise were fast Fourier transformed and compared. The average energy content of the response between 0 and 5 kHz was calculated by the software and the 2-to 4-kHz band was analyzed, since this is the only TEOAE frequency band consistently present in the rat [Khvoles et al, 1996[Khvoles et al, , 1999. A TEOAE measurement was considered to be a true response if a typical pattern was seen within the first 5 ms after stimulus which repeated itself in the two buffers A and B, and if the average energy 132 Audiol Neurootol 2003;8:129-139 Fraenkel/Freeman/Sohmer content at 2-4 kHz was at least 3 dB larger in the response (A + B) than in the noise (A -B).…”

Section: Otoacoustic Emissionsmentioning

confidence: 99%

Susceptibility of Young Adult and Old Rats to Noise-Induced Hearing Loss

Fraenkel¹,

Freeman²,

Sohmer³

2003

Audiol Neurotol

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This study was designed to test whether old rats show signs of presbyacusis and whether they would be either similarly or more or less susceptible to noise-induced hearing loss than young adult rats. Old (24 months) and young adult (3–4 months) Wistar rats were exposed to a broad-band noise of 113 dB SPL for a duration of 1 h (producing temporary threshold shifts) or 3 days (12 h noise/12 h quiet; permanent shifts). Auditory brainstem response (ABR), distortion product otoacoustic emissions (DPOAEs) and transient evoked otoacoustic emissions (TEOAEs) were measured before and after exposure. At the initial recording (before exposure), old rats demonstrated a small mean ABR threshold elevation, a reduction in amplitude of wave I (WI), a shortening of WI latency and a prolongation of the interpeak interval between WI and WIV, as compared to the young rats. The old rats also demonstrated a small DPOAE amplitude reduction and a reduction of peak-to-peak amplitude in the TEOAE response 2 ms after stimulus, but no reduction in TEOAE energy content between 2 and 4 kHz. These are signs of presbyacusis in the old rats. The noise exposures caused elevations in ABR threshold and reductions in DPOAE amplitude and TEOAE energy content that were similar in both the old and young rats. Their recovery from the noise-induced loss was also similar. Thus, the results of this study show that old and young adult rats, at least when considering clinically relevant intensities and durations of noise exposure, are equally susceptible to the effects of the exposure.

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“…Although DPOAEs were recorded in many laboratory animals, there has not been much success in TEOAE recording in nonprimate mammals except for guinea pigs [Khvoles et al, 1996]. After refining the technique, TEOAEs were recorded by the same instrumentation and techniques used in rats, mice, rabbits, and guinea pigs [Khvoles et al, 1999]. The present study was performed to study the possible protective effect of cilostazol against amikacin-induced ototoxicity in rats.…”

Section: Introductionmentioning

confidence: 99%

Cilostazol Effect on Amikacin-Induced Ototoxicity: An Experimental Study

El‐Anwar

Abdelmonem²,

Nada³

et al. 2016

Audiol Neurotol

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Objectives: To find out the possible protective effect of cilostazol against amikacin-induced ototoxicity. Methods: This study was carried out on 24 adult male rats classified into 4 equal groups of 6 animals each. (1) The control group was administered saline (1 ml/day, p.o.) for 14 days. (2) The amikacin group was administered amikacin (200 mg/kg, i.m.) once daily for 14 days. (3) The cilostazol-amikacin (14 days) group was administered cilostazol (30 mg/kg, p.o.) once daily and amikacin (200 mg/kg, i.m.) once daily for 14 days. (4) The cilostazol (28 days)-amikacin (14 days) group was administered cilostazol (30 mg/kg, p.o.) once daily for 28 days and amikacin (200 mg/kg, i.m.) once daily for 14 days. Changes in the transient evoked otoacoustic emissions (TEOAEs) in the 4 groups were interpreted statistically. Results: No reported significant differences in TEOAE levels were detected between the groups at the start of the study. In all frequency bands, TEOAEs disappeared after amikacin treatment in the amikacin-alone group and remained absent in the amikacin-cilostazol (14 days) group, while TEOAEs reappeared in the amikacin-cilostazol (28 days) group. Conclusion: Cilostazol treatment for 28 days had a protective effect against amikacin-induced ototoxicity in rats.

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Transient Evoked Otoacoustic Emissions in Laboratory Animals

Cited by 13 publications

References 16 publications

Effects of microwaves (900 MHz) on the cochlear receptor: exposure systems and preliminary results

Effects of microwaves (900 MHz) on the cochlear receptor: exposure systems and preliminary results

Susceptibility of Young Adult and Old Rats to Noise-Induced Hearing Loss

Cilostazol Effect on Amikacin-Induced Ototoxicity: An Experimental Study

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