Transient evoked otoacoustic emissions can be recorded in the rat

Khvoles, Roza; Freeman, Sharon; Sohmer, Haim

doi:10.1016/s0378-5955(96)80013-x

Cited by 26 publications

(21 citation statements)

References 22 publications

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“…TEOAEs were first apparent in this rat on PND 15. As in the previous study [Khvoles et al, 1996], the TEOAE probably began within the 1.1-ms suppression period and the endpoint (of the repeatable response in the two recordings A and B) was less than 5 ms. In the frequency domain, the response shows a broad peak mainly in the 2-to 4-kHz range throughout development.…”

Section: Resultssupporting

confidence: 67%

“…The responses to stimulus intensity of 50 dB SPL were at least 3 dB above the noise and they disappeared into the noise floor almost immediately postmortem showing that these more active responses are more energy dependent. The more passive DPOAEs to the higher intensities decreased postmortem and disappeared within 30-45 min (Khvoles et al, 1996].…”

Section: Methodsmentioning

confidence: 88%

“…This method allows the recording of the nonlinear components of cochlear amplifier function while eliminating any component (including artifact) which grows in a linear fashion with stimulus intensity. The use of this technique in rats has been described previously in greater detail [Khvoles et al, 1996]. Adapters made of flexible plastic tubing, with an outer diameter of 2.45-2.55 mm (depending on the size of the ear canal) and an inner diameter of 2 mm and with a length of 10 mm extending beyond the tip of the probe, were fitted over the probe containing the sound sources and the microphone in order to seal it into the ear canal.…”

Section: Methodsmentioning

confidence: 99%

“…The frequency spectrum of the response was always at least 3 dB above that of the noise. The frequency band between 2 and 4 kHz was evaluated since this band includes the major part of the TEOAE energy in rats [Khvoles et al, 1996]. In guinea pigs, using the same instrumentation and technique, the major energy bands of the TEOAEs are 0.5-2 and 3-4.5 kHz [Khvoles et al, 1996].…”

Section: Methodsmentioning

confidence: 99%

“…These are necessary since TEOAEs in rats have very short durations -approximately 5 ms [Khvoles et al, 1996]. The purpose of the present study was to determine the various response parameters of the TEOAEs as a function of age (postnatal day; PND), to determine whether they are similar to those of the DPOAEs recorded in the same animals and to relate OAE appearance to other developmental factors taking place at the same time in the ear in order to try to understand the mechanisms involved in the maturation of the different OAEs and through them, of the active cochlear amplifier.…”

Section: Introductionmentioning

confidence: 99%

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Development of Transient Evoked Otoacoustic Emissions in the Neonatal Rat

Khvoles¹,

Freeman²,

Sohmer³

1998

Audiol Neurotol

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Otoacoustic emissions (OAEs) represent acoustic energy generated by the cochlear amplifier which contributes to auditory sensitivity and frequency discrimination. Therefore the OAEs can serve as a noninvasive tool to study the cochlear amplifier. While transient evoked OAEs (TEOAEs) are generally recorded clinically in man, it has been difficult to record them in animals and instead cubic distortion product OAEs (DPOAEs) have been experimentally studied in animals. In a previous study, we perfected a method of recording TEOAEs routinely in rats and this technique was used here to study the development of OAEs in neonatal rats. TEOAEs were recorded and compared to the DPOAEs on several postnatal days. With increasing postnatal age, TEOAE peak-to-peak amplitude and spectral energy in the 2- to 4-kHz band increased, their threshold decreased and their input-output functions became less monotonic with a change in slope (notch and/or plateau) in the mid-intensity region. The DPOAEs to higher frequencies appeared first, then the TEOAEs, followed by the DPOAEs to lower frequencies. With age, their amplitude also increased, thresholds decreased and a notch appeared in their input-output functions. The TEOAEs were measurable during the continuum of the appearance of the DPOAEs and the developmental sequences of both types of OAEs were similar. This may be evidence that similar mechanisms account for their maturation which probably initially involves a reduction in the air-bone gap with maturation of the outer and middle ears, and then elevation of the endocochlear potential and additional micromechanical maturations.

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Section: Resultssupporting

confidence: 67%

Section: Methodsmentioning

confidence: 88%

Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Development of Transient Evoked Otoacoustic Emissions in the Neonatal Rat

Khvoles¹,

Freeman²,

Sohmer³

1998

Audiol Neurotol

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Effects of microwaves (900 MHz) on the cochlear receptor: exposure systems and preliminary results

Marino¹,

Cristalli

Galloni³

et al. 2000

Radiation and Environmental Biophysics

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The purpose of this paper is to present the experimental device and the work in progress performed in search for objective organic correlation of damage to hearing, examining possible acoustic otofunctional effects on the cochlear epithelium of the rat due to exposure to microwaves (900 MHz). Two experiments using male Sprague-Dawley rats were carried out with a far-field exposure in a cubic chamber. No statistically significant evidence was obtained at both specific absorption rate (SAR) values. The exposure system and the diagnostic apparatus are extremely useful to investigate a potential effect on the auditory system: however, with the parameters applied in these experiments, no evidence was observed.

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Effects of extremely low frequency electromagnetic fields on transient evoked otoacoustic emissions in rabbits

Budak

Öztürk

et al. 2009

International Journal of Pediatric Otorhinolaryngology

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Transient evoked otoacoustic emissions can be recorded in the rat

Cited by 26 publications

References 22 publications

Development of Transient Evoked Otoacoustic Emissions in the Neonatal Rat

Development of Transient Evoked Otoacoustic Emissions in the Neonatal Rat

Effects of microwaves (900 MHz) on the cochlear receptor: exposure systems and preliminary results

Effects of extremely low frequency electromagnetic fields on transient evoked otoacoustic emissions in rabbits

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