Transient eruptive seborrheic keratoses associated with erythrodermic psoriasis and erythrodermic drug eruption: Report of two cases

Flugman, Scott L.; McClain, Steve A.; Clark, Richard A.F.

doi:10.1067/mjd.2001.103641

Cited by 30 publications

(19 citation statements)

References 8 publications

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“…Resolution of the seborrheic keratoses was often achieved with treatment of the underlying condition rather than any specific treatment for the keratoses. 3,4,6 The case presented here is unique because this patient's eruption began as discrete eruptive seborrheic keratoses surrounded by a halo of erythema. The erythema progressed after the initial eruptions to later become confluent in areas, especially his torso.…”

Section: Discussionmentioning

confidence: 99%

“…6 In these cases, the eruptive seborrheic keratoses developed either in the presence of erythroderma or after its appearance. Resolution of the seborrheic keratoses was often achieved with treatment of the underlying condition rather than any specific treatment for the keratoses.…”

Section: Discussionmentioning

confidence: 99%

“…Eruptive seborrheic keratoses can be a sign of internal malignancy (sign of Leser-Trelat), or associated with noncancerous conditions such as inflammatory dermatoses and drug reactions. [2][3][4][5][6][7] We present an unusual case of eruptive seborrheic keratoses associated with adalimumab (Humira) use, which to our knowledge, has not been reported before.…”

Section: Introductionmentioning

confidence: 99%

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Eruptive seborrheic keratoses associated with adalimumab use

Eastman

Knezevich

Raugi³

2013

J Dermatol Case Rep

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Background: Seborrheic keratoses are common, benign cutaneous growths, however in rare situations they can acutely erupt in large numbers. Eruptive seborrheic keratoses can be associated with internal malignancy (sign of Leser-Trelat), but may also appear in conjunction with inflammatory dermatoses and adverse drug reactions. Main observation:A 71-year-old Caucasian man presented with acute onset of a pruritic, burning papular erythematous rash on his chest, upper extremities and lower extremities after a routine adalimumab injection for rheumatoid arthritis. Two skin biopsies obtained showed findings diagnostic of seborrheic keratoses. Spontaneous resolution of the diffuse eruptive seborrheic keratoses was achieved within 3 months of discontinuing adalimumab therapy. Conclusions:We believe the development of eruptive seborrheic keratoses due to adalimumab therapy is rare, and because our patient responded promptly to discontinuation of the drug we suggest this should be the preferred course of action in future cases.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Eruptive seborrheic keratoses associated with adalimumab use

Eastman

Knezevich

Raugi³

2013

J Dermatol Case Rep

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“…Öte yandan, erüptif seboreik keratozların malinitesi olmayan hastalarda da görülebileceğine dikkat çekilmiştir (psödo-Leser-Trélat belirtisi) 2 . Benzer olarak eritrodermiye yol açan inflamatuvar dermatozlar (psoriazis, pitriazis rubra pilaris), ilaç reaksiyonları, gebelik ve adalimumab kullanımının da erüptif seboreik keratozlara neden olabileceği bildirilmiştir 1,[4][5][6] . Günlük dermatoloji pratiğinde çok sayıda seboreik keratozla karşılaşıldığında ani ortaya çıkma yönünden sorgulama yapılsa da, böyle bir ilişkinin çok net tanımlanmadığı durumlarda iç organ maliniteleri yönünden rutin bir inceleme yapılmamaktadır.…”

Section: Seboreik Keratozunclassified

Selim deri tümörleri ve sistemik malinite ilişkisi

Yazganoğlu¹,

Baykal²

2013

TURKDERM

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ÖzetDerinin karmaşık histolojik görüntüsü ile ilişkili olarak çok sayıda selim deri tümörü tipi vardır. Bunlardan az bir bölümü sistemik maliniteler ile ilişki gösterebilir. Bu makalede sistemik maliniteler ile ilişkisi iyi bilinen veya tartışmalı olan selim deri tümörlerinden bahsedilecektir. Bahsi geçen tümörler ve ilişkili olduğu durumlar şunlardır: seboreik keratoz/ Leser-Trélat belirtisi, lentigo simpleks/ Peutz Jeghers ve Carney sendromu, yağ bezi tümörleri/Muir-Torre sendromu, fibrofoliküloma-trikodiskoma/ Birt-Hogg-Dubé sendromu, trikoepitelyom-silindrom-spiradenom/ BrookeSpiegler sendromu, leiomyom/ multipl kutane ve uterin leiyomiyomatozis sendromu, glomeruloid hemanjiyom/ POEMS sendromu, venöz malformasyon/ Maffucci sendromu, mukozal nörom/ multipl endokrin neoplazi tip 2B, jüvenil ksantogranülom/ jüvenil kronik miyeloid lösemi. Deri tümörleri ve ilişkili olduğu belirtilerin veya sendromların sistemik malinite riskinin bilinmesi, malinitelerin erken tanısı açısından önem taşır. Sum maryThere are various types of benign skin tumors in association with the complex nature of the skin. A minor part of them may be associated with visceral malignancies. This review focuses on the benign skin tumors that are described to have well-known associations with systemic malignancies or those with controversial associations. These tumors and the associated conditions are as follows: seborrheic keratosis/ Leser-Trélat sign, lentigo simplex/Peutz Jeghers and Carney syndrome, sebaceous tumors/ Muir-Torre syndrome, fibrofolliculoma-trichodiskoma/ Birt-Hogg-Dubé syndrome, trichoepitheliomacylindroma-spiradenoma/ Brooke-Spiegler syndrome, leiomyoma/multiple cutaneous and uterin leiomyomatosis syndrome, glomeruloid hemangioma/ POEMS syndrome, venous malformation/ Maffucci syndrome, mucosal neuroma/ multiple endocrine neoplasia type 2B, juvenile xanthogranuloma/ juvenile chronic myeloid leukemia. It is important to know the skin tumors related with visceral malignancies in part of a syndrome or in association with a sign as this may yield an earlier recognition of these malignancies. (Turkderm 2013; 47

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“…1,2,5,6 Other types of malignancies reported include hematological malig- nancies, lung cancer, osteogenic sarcoma, leiomyosarcoma, melanoma, nasopharyngeal carcinoma.…”

Section: -4mentioning

confidence: 99%

A Case with the Sign of Leser-Trélat

İyidal¹,

Kılıç²,

Gül³

et al. 2015

Turkiye Klinikleri J Case Rep

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A AB BS ST TR RA AC CT T The sign of Leser-Trelat is an eruptive appearance or increase in the number of seborrheic keratoses. It is usually associated with underlying internal malignancy, especially gastric adenocarcinoma. Herein, we report a case of Leser-Trelat syndrome that preceeded the diagnosis of both prostate adenocarcinoma and cutaneous squamous cell carcinoma. Since Leser-Trelat syndrome may be the presenting sign of a new or recurrent tumour, we would like to emphasize the importance of the possibility of an underlying neoplasm and suggest appropriate screening.K Ke ey y W Wo or rd ds s: : Paraneoplastic syndromes; keratosis, seborrheic Ö ÖZ ZE ET T Leser-Trelat belirtisi seboreik keratozların aniden ortaya çıkışı ya da sayısında artışı olarak tanımlanır. Özellikle gastrik adenokarsinom olmak üzere altta yatan iç organ maligniteleri ile ilişkilidir. Bu yazıda, hem prostat adenokarsinomu hem de kutanöz yassı hücreli karsinoma tanılar-ına öncülük eden Leser-Trelat sendromlu bir olguyu sunuyoruz. Leser-Trelat sendromu yeni ya da tekrarlayan bir tümörün ilk bulgusu olabileceği için, altta yatan neoplazm olasılığının önemini vurgulayarak olgularda gerekli tetkiklerin yapılmasını öneriyoruz.A An na ah ht ta ar r K Ke el li im me el le er r: : Paraneoplastik sendromlar; keratoz, seboreik T Tu ur rk ki iy ye e K Kl li in ni ik kl le er ri i J J C Ca as se e R Re ep p 2 20 01 15 5; ;2 23 3( (3 3) ): :2 24 43 3--6 6

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Transient eruptive seborrheic keratoses associated with erythrodermic psoriasis and erythrodermic drug eruption: Report of two cases

Cited by 30 publications

References 8 publications

Eruptive seborrheic keratoses associated with adalimumab use

Eruptive seborrheic keratoses associated with adalimumab use

Selim deri tümörleri ve sistemik malinite ilişkisi

A Case with the Sign of Leser-Trélat

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