Transient elevation of temperature promotes cross-linking of α-crystallin-client proteins through formation of advanced glycation endproducts: A potential role in presbyopia and cataracts

Nandi, Sandip K.; Rankenberg, Johanna; Glomb, Marcus A.; Nagaraj, Ram H.

doi:10.1016/j.bbrc.2020.10.018

Cited by 11 publications

(10 citation statements)

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“…We adjusted for proxy exposures, including occupation, study areas, and physical activity levels in the regression models, but residual confounding is still likely. Heat exposure related to cooking is another potential confounder for eye disease (particularly cataracts [58,59]), although the relevant epidemiological evidence is scarce and little direct data exist to compare heat exposure in the eyes of solid fuels to clean fuels users. Further epidemiological studies measuring not only household air pollution but also heat exposure to the eyes would help to tease out their independent associations with eye disease.…”

Section: Plos Medicinementioning

confidence: 99%

Long-term solid fuel use and risks of major eye diseases in China: A population-based cohort study of 486,532 adults

et al. 2021

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Background Over 3.5 billion individuals worldwide are exposed to household air pollution from solid fuel use. There is limited evidence from cohort studies on associations of solid fuel use with risks of major eye diseases, which cause substantial disease and economic burden globally. Methods and findings The China Kadoorie Biobank recruited 512,715 adults aged 30 to 79 years from 10 areas across China during 2004 to 2008. Cooking frequency and primary fuel types in the 3 most recent residences were assessed by a questionnaire. During median (IQR) 10.1 (9.2 to 11.1) years of follow-up, electronic linkages to national health insurance databases identified 4,877 incident conjunctiva disorders, 13,408 cataracts, 1,583 disorders of sclera, cornea, iris, and ciliary body (DSCIC), and 1,534 cases of glaucoma. Logistic regression yielded odds ratios (ORs) for each disease associated with long-term use of solid fuels (i.e., coal or wood) compared to clean fuels (i.e., gas or electricity) for cooking, with adjustment for age at baseline, birth cohort, sex, study area, education, occupation, alcohol intake, smoking, environmental tobacco smoke, cookstove ventilation, heating fuel exposure, body mass index, prevalent diabetes, self-reported general health, and length of recall period. After excluding participants with missing or unreliable exposure data, 486,532 participants (mean baseline age 52.0 [SD 10.7] years; 59.1% women) were analysed. Overall, 71% of participants cooked regularly throughout the recall period, of whom 48% used solid fuels consistently. Compared with clean fuel users, solid fuel users had adjusted ORs of 1.32 (1.07 to 1.37, p < 0.001) for conjunctiva disorders, 1.17 (1.08 to 1.26, p < 0.001) for cataracts, 1.35 (1.10 to 1.66, p = 0.0046) for DSCIC, and 0.95 (0.76 to 1.18, p = 0.62) for glaucoma. Switching from solid to clean fuels was associated with smaller elevated risks (over long-term clean fuel users) than nonswitching, with adjusted ORs of 1.21 (1.07 to 1.37, p < 0.001), 1.05 (0.98 to 1.12, p = 0.17), and 1.21 (0.97 to 1.50, p = 0.088) for conjunctiva disorders, cataracts, and DSCIC, respectively. The adjusted ORs for the eye diseases were broadly similar in solid fuel users regardless of ventilation status. The main limitations of this study include the lack of baseline eye disease assessment, the use of self-reported cooking frequency and fuel types for exposure assessment, the risk of bias from delayed diagnosis (particularly for cataracts), and potential residual confounding from unmeasured factors (e.g., sunlight exposure). Conclusions Among Chinese adults, long-term solid fuel use for cooking was associated with higher risks of not only conjunctiva disorders but also cataracts and other more severe eye diseases. Switching to clean fuels appeared to mitigate the risks, underscoring the global health importance of promoting universal access to clean fuels.

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Section: Plos Medicinementioning

confidence: 99%

Long-term solid fuel use and risks of major eye diseases in China: A population-based cohort study of 486,532 adults

et al. 2021

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“…Lifelong exposure to small increases in temperature may, therefore, contribute to the accelerated aging process of the lens by accelerating the metabolic rate of the lenticular epithelium ( 33 ). Nandi demonstrated that the transient and subtle temperature elevations in the lens of the eye could result in protein cross-linking through AGEs and cause age-related cataracts ( 34 ). Studies in animals have shown that cataracts may develop when the temperature of the eye's lens increases with the temperature of its surroundings.…”

Section: Discussionmentioning

confidence: 99%

“…Evidence generated from animal models is not directly comparable to that in humans. The evidence generated from animal models does not directly indicate that humans develop cataracts in high-temperature environments due to similar mechanisms of temperature rise, but the possibility remains ( 34 ).…”

Section: Discussionmentioning

confidence: 99%

Associations of Humidity and Temperature With Cataracts Among Older Adults in China

Gao

et al. 2022

Front. Public Health

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BackgroundThe burden of cataracts was substantial in the current aging world. However, few epidemiological studies have examined the associations between climate and weather conditions and cataract in older populations. We aimed to investigate the associations of air relative humidity and temperature with cataracts in older adults in China.MethodsWe used the cohort data from 2002, 2005, 2008, 2011, 2014, and 2018 waves of the Chinese Longitudinal Healthy Longevity Survey (CLHLS). A total of 62,595 Chinese older adults aged between 65 and 105 years were included in the analyses. City-level annual average air humidity and temperature during 2001 and 2017 (before the survey year) was used to measure population exposure. A cataract was self-reports based on the medical record or the doctor's diagnosis and 8,071 older adults had cataract. Covariates included socio-demographic, health status, lifestyles, and chronic conditions. We adopted the Generalized estimation equation (GEE) model to analyze the associations of relative humidity and temperature with cataracts.ResultsWe found that the average relative humidity (OR: 0.99; 95% CI: 0.98–0.99) in the past year was inversely associated with cataract likelihoods in older adults and a positive association between temperature (OR: 1.04; 95%CI: 1.03,1.05) in the past year and cataract likelihoods in older adults. The associations were robust in stratified analyses by sex, urban/rural residence, and education level. Furthermore, we found a nonlinear J-shaped relationship between temperature and cataract prevalence.ConclusionOur findings provide the evidence that higher temperature and low relative humidity may be associated with cataracts in older adults.

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“…Presbyopia—the loss of the lens’ accommodative ability to focus on nearby objects—begins in most humans around and beyond the age of 40, regardless of any prior vision condition. Several factors are proposed to explain the underlying cause of presbyopia, including lens hardening [ 3 , 4 , 5 , 6 , 7 ], lens growth [ 8 ], aging of the ciliary muscle [ 9 ], lens capsule [ 10 ], and vitreous [ 11 ]. Recent discoveries suggest that age-related loss in lens elasticity is the preeminent factor for presbyopia [ 3 , 4 , 6 , 12 , 13 , 14 ].…”

Section: Introductionmentioning

confidence: 99%

An AFM Approach Applied in a Study of α-Crystallin Membrane Association: New Insights into Lens Hardening and Presbyopia Development

2022

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The lens of the eye loses elasticity with age, while α-crystallin association with the lens membrane increases with age. It is unclear whether there is any correlation between α-crystallin association with the lens membrane and loss in lens elasticity. This research investigated α-crystallin membrane association using atomic force microscopy (AFM) for the first time to study topographical images and mechanical properties (breakthrough force and membrane area compressibility modulus (KA), as measures of elasticity) of the membrane. α-Crystallin extracted from the bovine lens cortex was incubated with a supported lipid membrane (SLM) prepared on a flat mica surface. The AFM images showed the time-dependent interaction of α-crystallin with the SLM. Force spectroscopy revealed the presence of breakthrough events in the force curves obtained in the membrane regions where no α-crystallin was associated, which suggests that the membrane’s elasticity was maintained. The force curves in the α-crystallin submerged region and the close vicinity of the α-crystallin associated region in the membrane showed no breakthrough event within the defined peak force threshold, indicating loss of membrane elasticity. Our results showed that the association of α-crystallin with the membrane deteriorates membrane elasticity, providing new insights into understanding the molecular basis of lens hardening and presbyopia.

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Transient elevation of temperature promotes cross-linking of α-crystallin-client proteins through formation of advanced glycation endproducts: A potential role in presbyopia and cataracts

Cited by 11 publications

References 28 publications

Long-term solid fuel use and risks of major eye diseases in China: A population-based cohort study of 486,532 adults

Long-term solid fuel use and risks of major eye diseases in China: A population-based cohort study of 486,532 adults

Associations of Humidity and Temperature With Cataracts Among Older Adults in China

An AFM Approach Applied in a Study of α-Crystallin Membrane Association: New Insights into Lens Hardening and Presbyopia Development

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