Transient electrophoresis of a charged porous particle

Lai, Yi‐Ting; Keh, Huan J.

doi:10.1002/elps.201900413

Cited by 19 publications

(17 citation statements)

References 47 publications

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“…133,134 In a uniform electric field, charged particles are drawn to the oppositely charged electrode, whereas uncharged particles are not influenced by the field (Figure 3A). 98,135,136 Different charged particles subjected to a uniform electric field experience different electrophoretic forces depending on the strength of the applied field, surrounding medium condition (viscosity, pH, and ionic strength), and electrophoretic mobility of particles. 131,137−139 DEP is the migration of electrically polarizable (dielectric) particles within a nonuniform electric field.…”

Section: Label-free Microfluidic Methods For Exosome Isolationmentioning

confidence: 99%

Label-Free Isolation of Exosomes Using Microfluidic Technologies

2021

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Exosomes are cell-derived structures packaged with lipids, proteins, and nucleic acids. They exist in diverse bodily fluids and are involved in physiological and pathological processes. Although their potential for clinical application as diagnostic and therapeutic tools has been revealed, a huge bottleneck impeding the development of applications in the rapidly burgeoning field of exosome research is an inability to efficiently isolate pure exosomes from other unwanted components present in bodily fluids. To date, several approaches have been proposed and investigated for exosome separation, with the leading candidate being microfluidic technology due to its relative simplicity, costeffectiveness, precise and fast processing at the microscale, and amenability to automation. Notably, avoiding the need for exosome labeling represents a significant advance in terms of process simplicity, time, and cost as well as protecting the biological activities of exosomes. Despite the exciting progress in microfluidic strategies for exosome isolation and the countless benefits of label-free approaches for clinical applications, current microfluidic platforms for isolation of exosomes are still facing a series of problems and challenges that prevent their use for clinical sample processing. This review focuses on the recent microfluidic platforms developed for labelfree isolation of exosomes including those based on sieving, deterministic lateral displacement, field flow, and pinched flow fractionation as well as viscoelastic, acoustic, inertial, electrical, and centrifugal forces. Further, we discuss advantages and disadvantages of these strategies with highlights of current challenges and outlook of label-free microfluidics toward the clinical utility of exosomes.

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Section: Label-free Microfluidic Methods For Exosome Isolationmentioning

confidence: 99%

Label-Free Isolation of Exosomes Using Microfluidic Technologies

2021

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“…Later, the start‐up electrophoretic motion of a spherical particle with a thin but finite double layer (

κ a \geq 10

) was investigated approximately, where the transient response of the electroosmotic flow in the thin double layer to the abruptly applied electric field was incorporated [16,17]. The starting electrophoretic response of a spherical particle having an arbitrary value of

κ a

to a step change in the imposed electric field has also been examined analytically [18,19].…”

Section: Introductionmentioning

confidence: 99%

Transient electrophoresis in a suspension of charged particles with arbitrary electric double layers

Lai

Keh

2021

Electrophoresis

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The startup of electrophoretic motion in a suspension of spherical colloidal particles, which may be charged with constant zeta potential or constant surface charge density, due to the sudden application of an electric field is analytically examined. The unsteady modified Stokes equation governing the fluid velocity field is solved with unit cell models. Explicit formulas for the transient electrophoretic velocity of the particle in a cell in the Laplace transforms are obtained as functions of relevant parameters. The transient electrophoretic mobility is a monotonic decreasing function of the particle-to-fluid density ratio and in general a decreasing function of the particle volume fraction, but it increases and decreases with a raise in the ratio of the particle radius to the Debye length for the particles with constant zeta potential and constant surface charge density, respectively. On the other hand, the relaxation time in the growth of the electrophoretic mobility increases substantially with an increase in the particle-to-fluid density ratio and with a decrease in the particle volume fraction but is not a sensitive function of the ratio of the particle radius to the Debye length. For specified values of the particle volume fraction and particle-to-fluid density ratio in a suspension, the relaxation times in the growth of the particle mobility in transient electrophoresis and transient sedimentation are equivalent.

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“…Saad and Faltas [41] investigated the problem of the transient electrophoretic response of a solid spherical particle embedded in the Brinkman medium under the effect of dynamic electroosmosis within a thin but finite double layer to the step application of an electric field. On the other hand, recently, Lai and Keh [42] presented a theoretical study for the transient electrophoretic response of a solid spherical particle having an arbitrary double layer with low

ζ

‐potential to a step change in the applied electric field.…”

Section: Introductionmentioning

confidence: 99%

Transient electrophoresis of a conducting spherical particle embedded in an electrolyte‐saturated Brinkman medium

2021

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In this study, the time‐dependent electrophoretic motion of a conducting spherical particle embedded in an arbitrary electrolyte solution saturated porous medium is investigated. The porous medium is uniformly charged and the embedded hard particle is charged with constant ζ‐potential or constant surface charge density. The unsteady modified Brinkman equation with an electric force term, which governs the fluid velocity field, is used to model the porous medium and is solved by Laplace's transform technique. An analytical expression for the electrophoretic velocity of the spherical particle is obtained in Laplace transform domain as a function of the relevant parameters, and its inversion is obtained through numerical techniques. Also, in this study, the steady‐state electrophoretic velocity is obtained analytically as linear functions of ζ‐potential (or surface density charge) and the fixed charge density. The steady‐state electrophoretic velocity is displayed graphically for various relevant parameters and compered with the available data in the literature. Also, the numerical values of the transient electrophoretic velocity are plotted versus the nondimensional elapsed time and discussed for different values of the Debye length parameter, density ratio, permeability of the porous medium, and for high and nonconducting particles.

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Transient electrophoresis of a charged porous particle

Cited by 19 publications

References 47 publications

Label-Free Isolation of Exosomes Using Microfluidic Technologies

Label-Free Isolation of Exosomes Using Microfluidic Technologies

Transient electrophoresis in a suspension of charged particles with arbitrary electric double layers

Transient electrophoresis of a conducting spherical particle embedded in an electrolyte‐saturated Brinkman medium

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