Transient elastography as a screening tool for liver fibrosis and cirrhosis in a community-based population aged over 45 years

Roulot, Dominique; Costes, Jean-Luc; Buyck, Jean-François; Warzocha, U.; Gambier, Nicolas; Czernichow, Sébastien; Clésiau, H. Le; Beaugrand, Michel

doi:10.1136/gut.2010.221382

Cited by 296 publications

(289 citation statements)

References 28 publications

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“…KS of a normal human allograft was comparable to renal stiffness in 10-week-old landrace pigs without tubulointerstitial fibrosis and corresponded very well to previously published renal allograft stiffness of 32.7 kPa [17]. Thus, the regular KS even exceeds the stiffness of an advanced liver cirrhosis >20 kPa which is most likely because of the higher abundance of connective tissues and vascularization in kidneys under physiological conditions [25][26][27]. Considering the upper detection limit of the Fibroscan device (75 kPa), only a small measuring range from 30 to 75 kPa remains for the kidneys [8].…”

Section: Discussionsupporting

confidence: 68%

Assessment of renal allograft fibrosis by transient elastography

et al. 2013

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SummaryTransient elastography (TE, Fibroscan) has been established as a noninvasive assessment tool of liver fibrosis. We evaluated potentials and limitations of TE for identifying renal allograft fibrosis. The technical possibility of kidney examination by TE was assessed in two 10-week-old German landrace pigs and kidney stiffness (KS) was evaluated in 164 renal transplant patients. KS could be determined in all animals at the pole and pars media (29 AE 10 kPa vs. 31 AE 17 kPa). In human renal allografts KS was successfully performed in 94.5% of the test series with reliable results in 72% of the measurements. Mean KS at the pole or pars media were comparable (35.0 AE 19.9 kPa vs. 33.2 AE 18.6 kPa). Significantly higher KS was detected in renal allografts with histologically confirmed advanced fibrosis. Bodymass-index, skin-allograft distance, and peri or intrarenal fluid accumulation were important confounders of successful KS measurements (BMI: r = À0.31; P < 0.001; distance: r = À0.50; P < 0.001). Notably, KS did not correlate with renal function. TE represents a noninvasive approach in selected transplant recipients to identify allografts with severe fibrosis. The heterogeneous kidney morphology and several other confounding factors negatively affect measurability of KS by TE. Further technical modifications are required to improve applicability of TE for kidney assessment.

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Section: Discussionsupporting

confidence: 68%

Assessment of renal allograft fibrosis by transient elastography

et al. 2013

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“…SWE within the normal range can rule out significant liver fibrosis when in agreement with the clinical and laboratory background (LoE 2A, GoR B) [60,61]. Broad consensus (17/ 0/1, 94 %)…”

Section: Recommendationmentioning

confidence: 87%

“…TE as a screening procedure in a general population > 45 years has been evaluated in two large studies, with a total of 4700 apparently healthy subjects [61,143]. One study found that the presence of diabetes mellitus and obesity was associated with a Young's modulus above 8 kPa.…”

Section: Screeningmentioning

confidence: 99%

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2017

Ultraschall in Med

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“…Moreover, a recent study suggests that TE may be useful for screening of CLD (Roulot et al 2011). However, because of paucity of studies so far there is no recommendation yet on the possible use of TE as method of mass screening of CLD (Castera 2011).…”

Section: Introductionmentioning

confidence: 99%