Transient elastography as a noninvasive assessment tool for hepatopathies of different etiology in pediatric type 1 diabetes mellitus

El-Kabbany, Zeinab A.; Elbarbary, Nancy Samir; Ismail, Eman Abdel Rahman; Mohamed, Nesrine A; Alem, Shereen Abdel; Ezzat, Yasmine M.; Maurice, Sarah; Hashem, Noha U.

doi:10.1016/j.jdiacomp.2016.09.009

Cited by 17 publications

(10 citation statements)

References 64 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The majority of studies with NAFLD in T1D performed only ultrasound [ 10 , 13 , 15 , 19 ]. Some performed MRI and found lower rates of NAFLD, but this resource is not widely available, it is expensive and time-consuming and therefore less applicable for screening purposes [ 32 , 33 ]. Also, to our knowledge, no former studies have been conducted determining CAP as well as fibrosis assessment in T1D so we present this data for the Brazilian population.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Prevalence of non-alcoholic fatty liver disease and its associated factors in individuals with type 1 diabetes: a cross-sectional study in a tertiary care center in Brazil

Barros

Monteiro

Terra

et al. 2021

Diabetol Metab Syndr

View full text Add to dashboard Cite

Background Data on non-alcoholic fatty liver disease (NAFLD) in individuals with type 1 diabetes (T1D) is controversial and so far, there are no published data on the Brazilian population. We investigated the prevalence of steatosis and hepatic fibrosis in a population with T1D from a tertiary care center in Brazil and its associated factors. Methods Ninety-five participants with T1D, aged 39 ± 13 years, with disease duration of 21 ± 9 years, being 55 (57.9%) females, from a university hospital in Rio de Janeiro, were screened for NAFLD with hepatic ultrasound (US) and transient elastography (TE). Results Prevalence of steatosis was, respectively, 12.6% and 16.8% when US and TE were used for diagnosis of NAFLD. Fibrosis was present in 8.4% of participants. A total of 31.6% of participants had at least one of the hepatic exams altered, which was associated with higher body mass index, waist circumference, hip circumference and waist-to-hip ratio,, presence of metabolic syndrome and higher triglycerides levels, even within the normal range. After multivariate analysis, presence of steatosis was only associated with metabolic syndrome and its component, triglycerides. Conclusion In our study, prevalence of NAFLD in ultrasound approximates the one found with TE. Fibrosis was not frequent. Screening should be reserved for participants with T1D and metabolic syndrome, as this was the main factor associated with NAFLD. Triglycerides levels were the only component of metabolic syndrome associated with steatosis. Further studies are necessary to determine the best screening strategy for NAFLD in individuals with T1D. Also, predisposing factors for development in fibrosis in T1D should be further explored in prospective studies.

show abstract

Section: Discussionmentioning

confidence: 99%

“…Also, to our knowledge, no former studies have been conducted determining CAP as well as fibrosis assessment in T1D so we present this data for the Brazilian population. We found two studies that used TE for fibrosis assessment in children and adolescents with T1D, but CAP is not mentioned [ 32 , 33 ].…”

Section: Discussionmentioning

confidence: 99%

Prevalence of non-alcoholic fatty liver disease and its associated factors in individuals with type 1 diabetes: a cross-sectional study in a tertiary care center in Brazil

Barros

Monteiro

Terra

et al. 2021

Diabetol Metab Syndr

View full text Add to dashboard Cite

show abstract

“…Compared to the heavy toll imposed on the liver by T2DM, epidemiological data on the burden of NAFLD imposed by T1DM (i.e., a disease that is characterized by an altered porto-systemic gradient of insulin and a lesser degree of insulin resistance compared to T2DM) appear to be more variable (summarized in Supplementary Table 2) [59][60][61][62][63][64][65][66][67] .…”

Section: T1dmmentioning

confidence: 99%

Nonalcoholic fatty liver disease and chronic vascular complications of diabetes mellitus

2017

View full text Add to dashboard Cite

Nonalcoholic fatty liver disease (NAFLD) and diabetes mellitus are common diseases that often coexist and might act synergistically to increase the risk of hepatic and extra-hepatic clinical outcomes. NAFLD affects up to 70-80% of patients with type 2 diabetes mellitus and up to 30-40% of adults with type 1 diabetes mellitus. The coexistence of NAFLD and diabetes mellitus increases the risk of developing not only the more severe forms of NAFLD but also chronic vascular complications of diabetes mellitus. Indeed, substantial evidence links NAFLD with an increased risk of developing cardiovascular disease and other cardiac and arrhythmic complications in patients with type 1 diabetes mellitus or type 2 diabetes mellitus. NAFLD is also associated with an increased risk of developing microvascular diabetic complications, especially chronic kidney disease. This Review focuses on the strong association between NAFLD and the risk of chronic vascular complications in patients with type 1 diabetes mellitus or type 2 diabetes mellitus, thereby promoting an increased awareness of the extra-hepatic implications of this increasingly prevalent and burdensome liver disease. We also discuss the putative underlying mechanisms by which NAFLD contributes to vascular diseases, as well as the emerging role of changes in the gut microbiota (dysbiosis) in the pathogenesis of NAFLD and associated vascular diseases.

show abstract

“…Also, we did not had access to studies that used TE for steatosis status in T1D so we present novel data. We found two studies that used TE for brosis assessment in children and adolescents with T1D, but CAP is not mentioned (31,32).…”

Section: Discussionmentioning

confidence: 99%

Prevalence of Non-alcoholic Fatty Liver Disease and Its Associated Factors in Admixed Individuals With Type 1 Diabetes: a Cross-sectional Study in a Tertiary Care Center in Brazil

Barros

Monteiro

Terra

et al. 2021

Preprint

View full text Add to dashboard Cite

Background: Data on non-alcoholic fatty liver disease (NAFLD) in admixed individuals with type 1 diabetes (T1D) is lacking. We investigated NAFLD in an admixed population with T1D from a tertiary care center in Brazil. Methods: Ninety-five participants with T1D, aged 39 ± 13 years, with disease duration of 21 ± 9 years, being 55 (57.9%) females, from a university hospital in Rio de Janeiro, were screened for NAFLD with hepatic ultrasound (US) and transient elastography (TE). Results: Prevalence of NAFLD was, respectively, 12.6% and 16.8% when US and TE were used. Fibrosis was present in 8% of participants. A total of 31.6% of participants had at least one of the hepatic exams altered, which was associated with higher anthropometric measurements, presence of metabolic syndrome and higher triglycerides levels, even within the normal range.Conclusion: In our study, prevalence of NAFLD in US approximates from the one found with TE. Screening should be reserved for participants with T1D and metabolic syndrome, as this was the main factor associated with NAFLD. Triglycerides levels were the only component of metabolic syndrome associated with NAFLD. Further studies are necessary to determine the best screening strategy for NAFLD in individuals with T1D from admixed populations.

show abstract

Transient elastography as a noninvasive assessment tool for hepatopathies of different etiology in pediatric type 1 diabetes mellitus

Cited by 17 publications

References 64 publications

Prevalence of non-alcoholic fatty liver disease and its associated factors in individuals with type 1 diabetes: a cross-sectional study in a tertiary care center in Brazil

Prevalence of non-alcoholic fatty liver disease and its associated factors in individuals with type 1 diabetes: a cross-sectional study in a tertiary care center in Brazil

Nonalcoholic fatty liver disease and chronic vascular complications of diabetes mellitus

Prevalence of Non-alcoholic Fatty Liver Disease and Its Associated Factors in Admixed Individuals With Type 1 Diabetes: a Cross-sectional Study in a Tertiary Care Center in Brazil

Contact Info

Product

Resources

About