Transient downregulation of glomerular atrial natriuretic factor receptors in high output heart failure in the rat

Gauquelin, G.; Mc, Bonhomme; García, Raúl

doi:10.1016/s0008-6363(96)88596-8

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Cardiovascular Research

1995

DOI: 10.1016/s0008-6363(96)88596-8

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Transient downregulation of glomerular atrial natriuretic factor receptors in high output heart failure in the rat

G. Gauquelin

Bonhomme Mc

Raúl García

Abstract: Downregulation of glomerular ANF receptors is a transient event during the development of high output heart failure in the rat. Thus the blunted renal response to ANF during chronic heart failure is not likely to be due to a decrease in renal ANF receptor density or affinity.

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Cited by 4 publications

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Possibility of age regulation of the natriuretic peptide C-receptor in human platelets

Giannessi

Andreassi

et al. 2001

J Endocrinol Invest

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Natriuretic peptide binding sites on platelets have been hypothesized to act as clearance receptors; however, there is no clear definition of the function of this receptor. The aim of the study was: 1) to characterize natriuretic peptide receptors in human platelets by original competition study; 2) to evaluate a possible age modulation of these binding sites, since a delayed clearance of ANP in the elderly has been observed. The binding of 125I-ANP to intact platelets was completely inhibited by h-ANP, h-BNP, h-CNP and c-ANP, the selective ligand of the clearance receptor. IC50 values were 0.089+/-0.029, 0.703+/-0.104 and 1.19+/-0.13, 3.84+/-0.04 nmol/l, mean+/-SE, respectively (p<0.001 for IC50 value of h-ANP compared to the other natriuretic peptides). This observation on the receptor selectivity of natriuretic peptides in human platelets provides new evidence for the presence of the clearance receptor on platelets. In control subjects the Kd was 34.6+/-4.0 pmol/l and Bmax 13.6+/-0.92 fmol/10(9) platelets (mean+/-SE), (no.=46, mean age 41.7+/-2.1 years). Bmax was significantly reduced in older subjects (no.=25, mean age 53.2+/-1.5 years) with respect to the younger group (no.=21, mean age 28.0+/-0.87 years): 11.4+/-1.1 vs 16.1+/-1.4 fmol/10(9) cells, p=0.0096, respectively; moreover, a significant inverse relationship between Bmax and the subject's age was observed. This observation suggests a possible reduction of the natriuretic peptide clearance with aging, associated to a significant increase of plasma levels of natriuretic peptides.

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Possibility of age regulation of the natriuretic peptide C-receptor in human platelets

Giannessi

Andreassi

et al. 2001

J Endocrinol Invest

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Up‐regulation of ‘clearance’ receptors in patients with chronic heart failure: a possible explanation for the resistance to biological effects of cardiac natriuretic hormones

Andreassi

Palmieri

et al. 2001

European J of Heart Fail

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The kidney in heart failure: Vasodilator‐natriuretic systems

Akama

McGrath

1997

Nephrology

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Congestive heart failure (CHF) is a complex clinical syndrome in which the kidney has a central pathophysiological role. An imbalance between vasoconstrictor-antinatriuretic and vasodilatornatriuretic forces is a key feature of the pathophysiology ofCHF. This review summarizes current understanding of disturbances in vasodilator-natriuretic systems in CHF. The key vasodilator systems involved are: the natriuretic peptide family atrial natriuretic peptide (ANP), brain natriuretic peptide (BNP), urodilatin, dopamine (DA), endothelium-derived relaxing factors and prostaglandins. Renal responses to ANP are blunted in CHF, under the influence of haemodynamic, neuro-humoral, receptor and post-receptor events. BNP, secreted in response to left ventricular load, may circulate in high concentrations in CHF, with similar effects to ANP. Urodilatin is a newly discovered peptide of renal origin whose physiological role is under investigation. Neural endopeptidase inhibitors have shown some promise in the treatment of human CHF, particularly when combined with ACE inhibition or angiotensin I1 receptor blockade. The renal DA system is influenced by sodium intake and DA metabolism is altered in CHF. The place of orally active DA prodrugs and DA agonist in the management of patients with CHF is still undecided. In CHF, basal release of nitric oxide may be preserved or even enhanced. However, stimulated release of nitric oxide may be reduced. Renal effects of nitric oxide or arginine in CHF have yet to be defined. Renal prostaglandins play an important role in offsetting renal and systemic vasoconstriction and fluid retention in CHF. The recent availability of specific receptor antagonist should lead to clearer definition of the relative roles of renal angiotensin I1 inhibition and bradykinin potentiation in the benefical responses to angiotensin converting enzyme (ACE-I) in CHF. Prostaglandin-El ( PG-El) and prostaglandin-Ez ( PG-Ez) infusion may have some benefit for the treatment of severe CHF. Adrenomedullin, a vasodilator-natriuretic peptide closely related to the calcitonin gene-related peptide family, is present in high concentrations in the kidney. Plasma concentrations of adrenomedullin are increased after acute cardiac injury and in CHF. Its roles in renal physiology and in the pathophysiology of CHF are under investigation. Overall, there is considerable potential to exploit these vasodilator-natriuretic systems in management strategies for CHF.

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Transient downregulation of glomerular atrial natriuretic factor receptors in high output heart failure in the rat

Abstract: Downregulation of glomerular ANF receptors is a transient event during the development of high output heart failure in the rat. Thus the blunted renal response to ANF during chronic heart failure is not likely to be due to a decrease in renal ANF receptor density or affinity.

Cited by 4 publications

References 0 publications

Possibility of age regulation of the natriuretic peptide C-receptor in human platelets

Possibility of age regulation of the natriuretic peptide C-receptor in human platelets

Up‐regulation of ‘clearance’ receptors in patients with chronic heart failure: a possible explanation for the resistance to biological effects of cardiac natriuretic hormones

The kidney in heart failure: Vasodilator‐natriuretic systems

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