Transient decrease in cerebral motor pathway fractional anisotropy after focal ischemic stroke in monkey

Chin, Yo; Sato, Yuki; Mase, Mitsuhito; Kato, Toshiya; Herculano, Bruno; Sekino, Masaki; Ohsaki, Hiroyuki; Ageyama, Naohide; Ono, Fumiko; Terao, Keiji; Yoshikawa, Yasuhiro; Hisatsune, Tatsuhiro

doi:10.1016/j.neures.2010.01.001

Cited by 14 publications

(15 citation statements)

References 27 publications

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“…13 In agreement with our data, some human 14 and nonhuman primate 9 animal studies reported an increase of FA in the acute phase of ischemia. In the subacute stage of ischemia (ie, 8 days), a decrease of FA values in the lesion was observed, which was reported in others species: rat, nonhuman primates, 15 and in humans. 16 In contrast, in the chronic stage (ie, 45 days), we did not observe any significant abnormality in FA values in restricted regions of WM (internal and external capsules) and GM (superior temporal cortex).…”

Section: Discussionsupporting

confidence: 77%

“…This profile of changes is in concordance with that reported in primates, including humans. 15,19 Interestingly, when bundles of fibers were analyzed as a function of their length, short fibers were preferentially altered. The significance of this alteration is not known but it may underlie the persistent sensorimotor deficits described in the present and previous studies.…”

Section: Discussionmentioning

confidence: 99%

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Diffusion Tensor MRI Reveals Chronic Alterations in White Matter Despite the Absence of a Visible Ischemic Lesion on Conventional MRI

Bihel

Roussel

Toutain

et al. 2011

Stroke

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Background and Purpose-The impact of stroke on white matter is poorly described in preclinical investigations mainly based on rodents with a low white (WM)/gray matter ratio. Using diffusion tensor imaging, we evaluated WM alterations and correlated them with sensorimotor deficits after stroke in the marmoset, a nonhuman primate that displays a WM/gray matter ratio close to that of humans. Methods-Marmosets underwent a transient brain ischemia (3-hour). Eight serial MRI examinations were made during ischemia and up to 45 days after reperfusion. The sensorimotor deficits were evaluated weekly over 45 days. To assess WM alterations, the SD of the angle of the first eigenvector projection was calculated in the cortex and in the internal and external capsules. The fiber-tracking approach was used to measure the number and the length of bundles. Results-Changes in the apparent diffusion coefficient and the fractional anisotropy values were similar during the temporal evolution of the lesion in the marmoset model of ischemia to that reported in patients with stroke. Despite an absence of visible lesions on T2-MRI and diffusion tensor imaging at the chronic stage, diffusion tensor MRI evidenced alterations in WM by the increase in the standard deviation of the angle of the first eigenvector projection in the cortex, internal and external capsules, and the decrease in the number of bundles of fibers tracked. The disruption of WM was strongly correlated with the chronic sensorimotor deficits. Conclusions-Despite an absence of a visible ischemic lesion at the chronic stage, diffusion tensor MRI revealed disorganization of WM, which probably underlies the persistence of functional deficits.

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Section: Discussionsupporting

confidence: 77%

Section: Discussionmentioning

confidence: 99%

Diffusion Tensor MRI Reveals Chronic Alterations in White Matter Despite the Absence of a Visible Ischemic Lesion on Conventional MRI

Bihel

Roussel

Toutain

et al. 2011

Stroke

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“…carried out serial DTI in transient MCAO in two macaques and compared diffusion parameters with motor function measurements. 86 The authors found transient decreases in FA values of affected motor pathways and suggested the recovery of FA correlates with motor recovery in the chronic phase.…”

Section: Conventional T1- and T2-mrimentioning

confidence: 96%

A review of current imaging methods used in stroke research

Wey

Desai

Duong

2013

Neurological Research

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Stroke is a serious healthcare problem with high mortality and long-term disability. However, to date, our ability to prevent and cure stroke remains limited. One important goal in stroke research is to identify the extent and location of lesion for treatment. In addition, accurately differentiating salvageable tissue from infarct and evaluating therapeutic efficacies are indispensible. These objectives could potentially be met with the assistance of modern neuroimaging techniques. This paper reviews current imaging methods commonly used in ischemic stroke research. These methods include positron emission tomography, computed tomography, T1 MRI, T2 MRI, diffusion and perfusion MRI, diffusion tensor imaging, blood–brain barrier permeability MRI, pH-weighted MRI, and functional MRI.

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“…Chin et al carried out serial diffusion tensor imaging in transient MCAO in two macaques and compared diffusion parameters with motor function measurements [25]. The authors reported transient decreases in FA values of affected motor pathways, and suggested the recovery of FA correlate accompanying gradual motor recovery in the chronic phase.…”

Section: Introductionmentioning

confidence: 99%

Multimodal MRI of Nonhuman Primate Stroke

Wey

Duong

2012

Transl. Stroke Res.

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Stroke is the fourth leading cause of death. Despite decades of research, no neuroprotective drug has proven to be effective clinically. One widely accepted view to account for this negative outcome is that the rodent stroke model simply does not adequately reflect the complexity of human stroke. Recent failures of several high-profile neuroprotective drugs for stroke treatment in phase III clinical trials further underscore the importance of developing adequate animal models for stroke research. The brain organization and vascular circuitry of nonhuman primates (NHPs) are more homologous with humans than the widely used rodent for stroke modeling. The Stroke Therapy Academic Industry Roundtable, a national committee commissioned by the American Heart Association, recommended that clinically relevant NHP stroke models be established for developing and assessing neuroprotective drugs. The aim of this article is to review the challenges and applications of magnetic resonance imaging studies of NHP stroke models.

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Transient decrease in cerebral motor pathway fractional anisotropy after focal ischemic stroke in monkey

Cited by 14 publications

References 27 publications

Diffusion Tensor MRI Reveals Chronic Alterations in White Matter Despite the Absence of a Visible Ischemic Lesion on Conventional MRI

Diffusion Tensor MRI Reveals Chronic Alterations in White Matter Despite the Absence of a Visible Ischemic Lesion on Conventional MRI

A review of current imaging methods used in stroke research

Multimodal MRI of Nonhuman Primate Stroke

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