“…Agents such as FK506, cyclosporin A and deoxyspergualin reduce inflammation and permit prolonged transgene expression. The mechanism of action of these agents is thought to involve prevention of neutralizing antibody formation [Vilquin et al, 1995;Smith et al, 1996;Yang et al, 1996a, b;Kaplan and Smith, 1997;Bouvet et al, 1998;Cichon and Strauss, 1998;Kuriyama et al, 1999]. Administration of monoclonal antibodies such as anti-CD40 ligand antibody and CTLA4Ig around the time of the first vector administration has also been shown to prevent the formation of neutralizing antibody against the adenovirus and permit successful readministration of the virus [Lei et al, 1996;Yang et al, 1996a, b;Scaria et al, 1997;Jooss et al, 1998].…”