Transient cholestatic hepatitis in a neonate associated with carbamazepine exposure during pregnancy and breast-feeding

Frey, Bernhard; Schubiger, Gregor; Musy, J. P.

doi:10.1007/bf02072057

Cited by 74 publications

(31 citation statements)

References 7 publications

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“…The majority of patients experienced no adverse effects. The experience of Taddio et al4 with 11 infants is especially reassuring; these authors showed that despite the presence of drug in the breast milk, no adverse effects were noted. However, the presence of significant infant serum concentrations and colic5 and irritability5'6 calls for caution in using this medication in a lactating woman.…”

Section: Discussionmentioning

confidence: 90%

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Fluoxetine and Carbamazepine Concentrations in a Nursing Motier/Infant Pair

Brent

Wisner

1998

Clin Pediatr (Phila)

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Section: Discussionmentioning

confidence: 90%

“…No further episodes occurred until 51/2 months, when the baby had peripheral cyanosis lasting[10][11][12][13][14][15] minutes and affecting the lips, up-…”

mentioning

confidence: 99%

Fluoxetine and Carbamazepine Concentrations in a Nursing Motier/Infant Pair

Brent

Wisner

1998

Clin Pediatr (Phila)

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“…Nevertheless, the drug is considered compatible with breastfeeding [7,22]–[25]. In fact, it is administered, with a good safety profile, directly to patients of pediatric age.…”

Section: Resultsmentioning

confidence: 99%

Antiepileptic drugs and breastfeeding

Davanzo

Bua

et al. 2013

Ital J Pediatr

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IntroductionThis review provides a synopsis for clinicians on the use of antiepileptic drugs (AEDs) in the breastfeeding mother.MethodsFor each AED, we collected all retrievable data from Hale’s “Medications and Mother Milk” (2012), from the LactMed database (2013) of the National Library of Medicine, and from a MedLine Search of relevant studies in the past 10 years.ResultsOlder AEDs, such as carbamazepine, valproic acid, phenytoin, phenobarbital, primidone are considered to have a good level of safety during lactation, due to the long term clinical experience and the consequent amount of available data from the scientific literature. On the contrary, fewer data are available on the use of new AEDs. Therefore, gabapentin, lamotrigine, oxcarbazepine, vigabatrin, tiagabine, pregabalin, leviracetam and topiramate are compatible with breastfeeding with a less documented safety profile. Ethosuximide, zonisamide and the continue use of clonazepam and diazepam are contraindicated during breastfeeding.ConclusionsAlthough the current available advice on the use of AEDs during breastfeeding, given by different accredited sources, present some contradictions, most AEDs can be considered safe according to our review.

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“…[2,3,8,[31][32][33][34][35][36][37][38][39][42][43][44][45][47][48][49][50][51][52]68,69] There are few published case reports describing adverse events for carbamazepine in the breast-fed infant. Frey et al [70] reported a transient cholestatic jaundice in association with maternal carbamazepine treatment during pregnancy and lactation. Cholestasis resolved after cessation of breast feeding.…”

Section: Carbamazepinementioning

confidence: 98%

Anticonvulsants and Breast Feeding

et al. 2000

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Progress in the diagnosis and management of seizure disorders and the availability of effective anticonvulsive medications has enabled increasing numbers of epileptic women of child-bearing age to raise families. Breast feeding, which these women may wish to choose, provides health, nutritional, immunological, developmental, social, economic and environmental benefits. The traditional anticonvulsants, such as phenytoin, carbamazepine and valproic acid (valproate sodium), are generally considered safe for use during breast feeding; however, observation for adverse effects is recommended. The use of phenobarbital while breast feeding is controversial because of its slow elimination by the nursing infant. The newer anticonvulsants, such as clobazam, felbamate, gabapentin, lamotrigine, oxcarbazepine, tiagabine, topiramate, and vigabatrin, are used mainly as adjunctive therapy. Data on the use of these drugs in pregnancy and lactation, and regarding long term effects on cognition and behaviour, are sparse. Weighing the benefits of breast feeding against the potential risk to the nursing infant, breast feeding is considered to be safe when the mother is taking carbamazepine, valproic acid or phenytoin. Infant monitoring for potential adverse effects is advisable when the mother is taking phenobarbital, clobazam, gabapentin, lamotrigine, oxcarbazepine or vigabatrin. Monitoring of infant serum drug concentrations is advisable but not compulsory. The use of felbamate, tiagabine and topiramate during breast feeding should await further study.

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Transient cholestatic hepatitis in a neonate associated with carbamazepine exposure during pregnancy and breast-feeding

Cited by 74 publications

References 7 publications

Fluoxetine and Carbamazepine Concentrations in a Nursing Motier/Infant Pair

Fluoxetine and Carbamazepine Concentrations in a Nursing Motier/Infant Pair

Antiepileptic drugs and breastfeeding

Anticonvulsants and Breast Feeding

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