Transient Binding Dynamics of Complement System Pattern Recognition Molecules on Pathogens
Maximilian Peter Götz,
Mario Alejandro Duque Villegas,
Beatrice Fageräng
et al.
Abstract:Previous studies of pattern recognition molecules (PRMs) of the complement system have revealed difficulties in observing binding on pathogens such as Aspergillus fumigatus and Escherichia coli, despite complement deposition indicative of classical and lectin pathway activation. Thus, we investigated the binding dynamics of PRMs of the complement system, specifically C1q of the classical pathway and mannose-binding lectin (MBL) of the lectin pathway. We observed consistently increasing deposition of essential … Show more
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