Transient axonal glycoprotein-1 (TAG-1) and laminin-α1 regulate dynamic growth cone behaviors and initial axon direction in vivo

Wolman, Marc A.; Sittaramane, Vinoth; Essner, Jeffrey J.; Yost, H. Joseph; Chandrasekhar, Anand; Halloran, Mary C.

doi:10.1186/1749-8104-3-6

Cited by 63 publications

(61 citation statements)

References 53 publications

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“…Sittaramane et al (Sittaramane et al, 2009) found that Cntn2-deficient specimens have defects in FBMN migration. Interestingly, as well as being expressed in FBMNs, Cntn2 protein is expressed on the MLF and is crucial for MLF fasciculation and pathfinding (Wolman et al, 2008). In preliminary Cntn2-depletion experiments (S.J.W.…”

Section: Research Articlementioning

confidence: 99%

Axon tracts guide zebrafish facial branchiomotor neuron migration through the hindbrain

Wanner

Prince

2013

Development

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SUMMARYAppropriate localization of neurons within the brain is a crucial component of the establishment of neural circuitry. In the zebrafish hindbrain, the facial branchiomotor neurons (FBMNs) undergo a chain-like tangential migration from their birthplace in rhombomere (r) 4 to their final destination in r6/r7. Here, we report that ablation of either the cell body or the trailing axon of the leading FBMN, or 'pioneer' neuron, blocks the migration of follower FBMNs into r5. This demonstrates that the pioneer neuron and its axon are crucial to the early migration of FBMNs. Later migration from r5 to r6 is not dependent on pioneer neurons but on the medial longitudinal fasciculus (MLF), a bundle of axons lying ventral to the FBMNs. We find that MLF axons enter r5 only after the pioneer neuron has led several followers into this region; the MLF is then contacted by projections from the FBMNs. The interactions between FBMNs and the MLF are important for migration from r5 to r6, as blocking MLF axons from entering the hindbrain can stall FBMN migration in r5. Finally, we have found that the adhesion molecule Cdh2 (N-cadherin) is important for interactions between the MLF and FBMNs, as well as for interactions between the trailing axon of the pioneer neuron and follower FBMNs. Interestingly, migration of pioneer neurons is independent of both the MLF and Cdh2, suggesting pioneer migration relies on independent cues.

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Section: Research Articlementioning

confidence: 99%

Axon tracts guide zebrafish facial branchiomotor neuron migration through the hindbrain

Wanner

Prince

2013

Development

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“…TAG-1 is expressed in many neuronal subpopulations as a glycosyl-phosphatidyl-inositol anchored form as well as a released form, and is implicated in neurogenesis, neurite extension, and fasciculation (Furley et Praag, 2008;Wolman et al, 2008;Lieberoth et al, 2009). In the adult, TAG-1 is expressed by neurons and by myelinating glia.…”

Section: Introductionmentioning

confidence: 99%

The Expression of TAG-1 in Glial Cells Is Sufficient for the Formation of the Juxtaparanodal Complex and the Phenotypic Rescue of Tag-1 Homozygous Mutants in the CNS

Savvaki¹,

Theodorakis²,

Zoupi³

et al. 2010

J. Neurosci.

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“…Whilst morpholino knockdown of Sema3D reduces L1 expression, its overexpression increases the surface expression of L1 in MLF axons (Wolman et al, 2007). In addition to L1, other CAMs, such as Tag1 (transiently expressed axonal glycoprotein 1), might be required for proper axon-axon interactions and for the guidance of MLF neurons (Wolman et al, 2008), demonstrating that the formation of even a relatively simple tract is governed by the concerted action of numerous components. Halloran's work is undoubtedly of wider significance, as it promises to inform the investigation of other systems.…”

Section: Regulating Responsiveness At the Receptor Levelmentioning

confidence: 99%

Functional diversity and mechanisms of action of the semaphorins

Eickholt

2008

Development

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SummaryThe second EMBO workshop on 'Semaphorin function and mechanisms of action', held in the gorgeous surroundings of the 12th Century Abbaye des Vaulx de Cernay near Paris, France this May, brought together a wide range of scientists working in diverse systems with a common interest: the semaphorins. Emerging new themes discussed at the meeting included the recognition of an increasingly complex way in which different cells regulate responsiveness, and the significance of considering semaphorins in the pathology of various diseases.

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Transient axonal glycoprotein-1 (TAG-1) and laminin-α1 regulate dynamic growth cone behaviors and initial axon direction in vivo

Cited by 63 publications

References 53 publications

Axon tracts guide zebrafish facial branchiomotor neuron migration through the hindbrain

Axon tracts guide zebrafish facial branchiomotor neuron migration through the hindbrain

The Expression of TAG-1 in Glial Cells Is Sufficient for the Formation of the Juxtaparanodal Complex and the Phenotypic Rescue of Tag-1 Homozygous Mutants in the CNS

Functional diversity and mechanisms of action of the semaphorins

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