Transient aplastic crisis triggered by parvovirus B19 in a family with hereditary spherocytosis

Aplastic anemia induced by human parvovirus B19 infection in an immunocompetent adult male without prior hematological disorders: A case report

“…If the patient's condition is not addressed, he or she may become critically ill. Sometimes the patient's condition deteriorates to the point where blood transfusion is necessary as in our patient [ 10 , 13 , 17 ]. Hence, the patient was admitted for close monitoring and supportive management (intravenous immunoglobulin and blood transfusion) was provided which was effective in improving the patient's clinical condition, and discharged with a strict follow-up schedule in the outpatient setting.…”

What is causing this infant's febrile lethargy?

“…3,7 The prevalence of parvovirus B19 antibodies found in serum sampling increases exponentially with age, from 2% in children under age 5 years to 85% of older adults. 3,5,8 Although erythema infectiosum facial rash is classically associated with parvovirus B19, it is rare in parvovirus B19-induced TAC, rendering it a challenging diagnosis without distinguishing features. 2,5,9 Reported fi ndings in parvovirus B19-associated TAC include tachycardia, pallor, and fatigue, likely from anemia, although each fi nding may be isolated and therefore require further investigation.…”

Acute human parvovirus B19 infection triggers immune‐mediated transient bone marrow failure syndrome, extreme direct hyperbilirubinaemia and acute hepatitis in patients with hereditary haemolytic anaemias: multicentre prospective pathophysiological study

“…It can also cause a sudden decrease in haemoglobin (Hb), reticulocytopenia, and erythropoiesis suppression translated into a life-threatening transient aplastic crisis (TAC) in patients with HHA. 3 Although many studies investigated the prevalence and manifestations of HPV-B19 infection in patients with SCA, 7,8 thalassaemia 9,10 and HS [11][12][13] separately, there is limited information about the extent to which HPV-B19 infection leads to severe complications and chronic infection. There are no prospective comparative studies that have investigated the risks associated with this pathogenic virus and predicted the course of disease and morbidity among patients with HHA categorised by their underlying diseases.…”