Transient anti-cytokine autoantibodies superimpose the hyperinflammatory response in Kawasaki disease and multisystem inflammatory syndrome in children: a comparative cohort study on correlates of disease

Netea, Stejara A.; Biesbroek, Giske; van Stijn, Diana; Ijspeert, Hanna; van der Made, Caspar I.; Jansen, Machiel H.; Geissler, Judy; van den Berg, J.M. (Merlijn); van der Kuip, Martijn; Gruppen, Mariken P.; Schonenberg-Meinema, Dieneke; Kapitein, Berber; van Furth, A.M. (Marceline) Tutu; Nagelkerke, Sietse Q.; Pajkrt, Dasja; Plötz, Frans B.; den Boer, M.E.J. (Lisette); Landman, Gijs W.; van Houten, Marlies A.; Goetschalckx, Ines; Toonen, Erik J.M.; van de Veerdonk, Frank L.; Kuipers, Irene M.; Dik, Willem A.; Kuijpers, Taco W.; Hendriks, T.; Felderhof, M.K.; Weggelaar, N.M.; Filippini, L.; Rozendaal, L.; Groeneweg, M.; Nuboer, R.; Bruijn, M.; Dolman, K.M.; Noordzij, J.G.; de Winter, J.P.; Vlieger, A.M.; Plötz, F.B.; Delemarre, L.C.

doi:10.1016/j.ebiom.2023.104736

Cited by 5 publications

(2 citation statements)

References 51 publications

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“…It was reported that in 21 children with MIS-C, 62% showed auto-antibodies against IL-1 receptor antagonist (IL-1RA) [ 95 ], which could explain the severe proinflammatory reaction in these patients. In another study, mainly anti-IFNγ auto-antibodies (in more than 80% of patients) were found, followed by auto-antibodies directed against IL-17, IFNα, IL-6, and IL-22 [ 96 ]. However, in a third study, no anti-IFNα auto-antibodies were found in 199 MIS-C patients [ 97 ].…”

Section: Viral Infectionsmentioning

confidence: 99%

Anticytokine Autoantibodies in Infectious Diseases: A Practical Overview

Arts,

Janssen,

van de Veerdonk

2023

IJMS

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Anticytokine autoantibodies (ACAAs) are a fascinating group of antibodies that have gained more and more attention in the field of autoimmunity and secondary immunodeficiencies over the years. Some of these antibodies are characterized by their ability to target and neutralize specific cytokines. ACAAs can play a role in the susceptibility to several infectious diseases, and their infectious manifestations depending on which specific immunological pathway is affected. In this review, we will give an outline per infection in which ACAAs might play a role and whether additional immunomodulatory treatment next to antimicrobial treatment can be considered. Finally, we describe the areas for future research on ACAAs.

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Section: Viral Infectionsmentioning

confidence: 99%

Anticytokine Autoantibodies in Infectious Diseases: A Practical Overview

Arts,

Janssen,

van de Veerdonk

2023

IJMS

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“…Nutrients 2023, 15, 3823 2 of 17 Kawasaki disease (KD) is an acute systemic vasculitis that primarily affects young children and results in arterial involvement [14]. The most common sequelae of KD are coronary artery lesions (CAL), which makes it the leading cause of acquired cardiovascular disease in children in developed countries [15].…”

Section: Introductionmentioning

confidence: 99%

Maternal Obesity and Kawasaki Disease-like Vasculitis: A New Perspective on Cardiovascular Injury and Inflammatory Response in Offspring Male Mice

Zheng,

Wang,

Huo

et al. 2023

Nutrients

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Maternal obesity affects the risk of cardiovascular disease and inflammatory response in offspring. However, the impact of maternal obesity on offspring with Kawasaki disease (KD), the leading cause of childhood acquired heart disease, is still an understudied area. This study aimed to elucidate the impact of maternal obesity on offspring in KD-like vasculitis and the underlying mechanisms. Offspring of obese female mice and normal diet dams were randomly divided into two subgroups. The pups were injected intraperitoneally with either Candida albicans water-soluble fraction (CAWS) or phosphate buffered saline (PBS) to establish the obesity (OB)-CAWS group, OB group, wild type (WT)-CAWS group, and WT group. Their weight was monitored during the study. After four weeks, echocardiography was applied to obtain the alternation of cardiac structures. Mouse cytokine panel, Hematoxylin-Eosin (HE) staining, western blot, and real-time qPCR were used to study the pathological changes and protein and RNA expression alternations. Based on the study of pathology, serology and molecular biology, maternal obesity lead to more severe vasculitis and induced altered cardiac structure in the offspring mice and promoted the expression of pro-inflammatory cytokines through activating the NF-κB signaling pathway. Maternal obesity aggravated the inflammatory response of offspring mice in KD-like vasculitis.

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