Transient and Persistent Representations of Odor Value in Prefrontal Cortex

Wang, Peter Y.; Boboilă, Cristian; Chin, Matthew; Higashi-Howard, Alexandra; Shamash, Philip; Zheng, Wu; Stein, Nicole P.; Abbott, L. F.; Axel, Richard

doi:10.1016/j.neuron.2020.07.033

Cited by 73 publications

(70 citation statements)

References 80 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Recent studies have begun investigating OFC activity using two-photon calcium imaging (Banerjee et al, 2020; Jennings et al, 2019; Namboodiri et al, 2019; Wang et al, 2020). Using this approach to longitudinally track neuronal activity across tasks, we identified neuronal subpopulations in vmOFC that signal learning rate.…”

Section: Discussionmentioning

confidence: 99%

Relative salience signaling within a thalamo-orbitofrontal circuit governs learning rate

Namboodiri

Hobbs

Pisanty

et al. 2020

Preprint

View full text Add to dashboard Cite

Learning to predict rewards is essential for the survival of animals. Contemporary views suggest that such learning is driven by a reward prediction error-the difference between received and predicted rewards. Here we show using two-photon calcium imaging and optogenetics in mice that a different class of reward learning signals exists within the orbitofrontal cortex (OFC). Specifically, the reward responses of many OFC neurons exhibit plasticity consistent with filtering out rewards that are less salient for learning (such as predicted rewards, or, unpredicted rewards available in a context containing highly salient aversive stimuli). We show using quasi-simultaneous imaging and optogenetics that this reward response plasticity is sculpted by medial thalamic inputs to OFC. These results provide a biological substrate for emerging theoretical views of meta-reinforcement learning in prefrontal cortex.

show abstract

Section: Discussionmentioning

confidence: 99%

Relative salience signaling within a thalamo-orbitofrontal circuit governs learning rate

Namboodiri

Hobbs

Pisanty

et al. 2020

Preprint

View full text Add to dashboard Cite

show abstract

“…And correlative evidence supporting this role continues to accumulate; in various choice tasks, neuronal activity in the OFC correlates with value in fMRI imaging, electrophysiological, and calcium imaging studies [13][14][15][16][17][18][19][20]. These value representations are adaptive to outcome and context changes [15,21,22], modulated by gaze fixation [23] and covert shift of attention [24], and supported by a mixture of temporally dynamic and stable coding schemes [25].…”

Section: Neural Correlates Of Value In the Ofcmentioning

confidence: 98%

“…For instance, individual OFC neurons can be found with activity tuned to cue and outcome identity [16,30], spatial locations [31,32], action selection [14,33,34], integration of prior and current information [14,18], decision confidence [26,35], and task rules [36]. Even in now-classic studies of neuroeconomic value, in which value is determined from integration of multiple reward features, many OFC neurons represent the value of only some options, and still more respond based on sensory features of the goods [6].…”

Section: Neural Correlates Of Value In the Ofcmentioning

confidence: 99%

Is the core function of orbitofrontal cortex to signal values or make predictions?

Zhou

Gardner

Schoenbaum

2021

Current Opinion in Behavioral Sciences

View full text Add to dashboard Cite

One dominant hypothesis about the function of the orbitofrontal cortex (OFC) is that the OFC signals the subjective values of possible outcomes to other brain areas for learning and decision making. This popular view generally neglects the fact that OFC is not necessary for simple value-based behavior (i.e., when values have been directly experienced). An alternative, emerging view suggests that OFC plays a more general role in representing structural information about the task or environment, derived from prior experience, and relevant to predicting behavioral outcomes, such as value. From this perspective, value signaling is simply one derivative of the core underlying function of OFC. New data in favor of both views have been accumulating rapidly. Here we review these new data in discussing the relative merits of these two ideas.

show abstract

“…The OFC is required for aspects of what is learned even in simple conditioning. 13,14 By inactivating OFC in a temporally specific manner only during pre-exposure, our chemogenetic approach provides a much more definitive test of the specific hypothesis that the OFC is required when it is necessary to infer that the PE cue predicts the absence of reward and should thus be ignored.…”

Section: Resultsmentioning

confidence: 99%