2020
DOI: 10.1097/j.pain.0000000000002114
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Transient activation of spinal trigeminal neurons in a rat model of hypoxia-induced headache

Abstract: The mechanisms underlying headaches attributed to hypoxia are poorly known. The activation of spinal trigeminal neurons with meningeal afferent input is believed to be responsible for the generation of headaches. In the caudal spinal trigeminal nucleus of anaesthetized and ventilated rats, the spontaneous firing of neurons with input from the exposed parietal dura mater and the activity evoked by mechanical stimuli to the dura and the adjacent periosteum were recorded, whereas the O2 fraction of the ventilatio… Show more

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Cited by 6 publications
(7 citation statements)
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“…In fact, oxygen can be involved in migraine pathogenesis in different ways that have been reviewed elsewhere (Bennett et al, 2015; Ciarambino et al, 2021; Taylor, 2011), although in the EMTVN, 100% oxygen had no direct effect on the neuronal responses to dural stimulation (Akerman et al, 2009). At the same time, lowering O 2 in the ventilation gas was accompanied by transient activation of the trigeminovascular neurons, while the prolonged hypoxia led to its progressive decrease or even termination (Waldmann & Messlinger, 2021). This cannot, however, explain the greater reduction of neuronal excitability under ventilation with room air, which rather provides normoxic conditions.…”
Section: Discussionmentioning
confidence: 99%
“…In fact, oxygen can be involved in migraine pathogenesis in different ways that have been reviewed elsewhere (Bennett et al, 2015; Ciarambino et al, 2021; Taylor, 2011), although in the EMTVN, 100% oxygen had no direct effect on the neuronal responses to dural stimulation (Akerman et al, 2009). At the same time, lowering O 2 in the ventilation gas was accompanied by transient activation of the trigeminovascular neurons, while the prolonged hypoxia led to its progressive decrease or even termination (Waldmann & Messlinger, 2021). This cannot, however, explain the greater reduction of neuronal excitability under ventilation with room air, which rather provides normoxic conditions.…”
Section: Discussionmentioning
confidence: 99%
“…In fact, oxygen can be involved in migraine pathogenesis in different ways that have been reviewed elsewhere (Bennett et al, 2015; Ciarambino et al, 2021; Taylor, 2011), although in the EMTVN, 100% oxygen had no direct effect on the neuronal responses to dural stimulation (Akerman et al, 2009). At the same time, lowering O 2 in the ventilation gas was accompanied by transient activation of the trigeminovascular neurons, while the prolonged hypoxia led to its progressive decrease or even termination (Waldmann and Messlinger, 2021). This cannot, however, explain the greater reduction of neuronal excitability under ventilation with room air, which rather provides normoxic conditions.…”
Section: Discussionmentioning
confidence: 99%
“…Tatsächlich sind mitochondriale Störungen ein Risikofaktor für die Manifestation einer Migräne [55]. Daneben findet man unter hypoxischen Bedingungen tierexperimentell eine erhöhte neuronale Aktivität in den kaudalen trigeminalen Kernen, die sensorische Eingänge aus der Dura haben [56]. Unklar ist dabei, ob diese Aktivierung durch aus trigeminalen Afferenzen freigesetztes CGRP erfolgt.…”
Section: Untersuchungen Zum Höhenkopfschmerzunclassified