Transglutaminase release and activity from novel poly(ε-caprolactone)-based composites prepared by foaming with supercritical CO2

Kravanja, Gregor; Primožič, Mateja; Knez, Željko; Leitgeb, Maja

doi:10.1016/j.supflu.2020.105031

Cited by 10 publications

(5 citation statements)

References 66 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The duration of the measurement at each pressure was approximately 120 min, as after this time, equilibrium was reached. To define the volume of the sample, a photo of the sample was taken with a digital camera and analyzed using ImageJ software [ 36 ].…”

Section: Methodsmentioning

confidence: 99%

Effect of Green Food Processing Technology on the Enzyme Activity in Spelt Flour

Leitgeb

Knez

Podrepšek

2022

Foods

Self Cite

View full text Add to dashboard Cite

In this research, a new approach to enzyme inactivation in flour was presented by supercritical technology, considered a sustainable technology with lower energy consumption compared to other technologies that use ultra-high temperature processing. Total protein concentration and the activity of enzymes α-amylase, lipase, peroxidase, polyphenol oxidase, and protease were determined in flour pre-treated with scCO2. During the study, it was observed that the activity of enzymes such as lipase and polyphenol oxidase, was significantly reduced under certain conditions of scCO2 treatment, while the enzymes α-amylase and protease show better stability. In particular, polyphenol oxidase was effectively inactivated below the 60% of preserved activity at 200 bar and 3 h, whereas α-amylase under the same conditions retained its activity. Additionally, the moisture content of the scCO2-treated spelt flour was reduced by 5%, and the fat content was reduced by 58%, while the quality of scCO2-treated flour was maintained. In this regard, the sustainable scCO2 process could be a valuable tool for controlling the enzymatic activity of spelt flour since the use of scCO2 technology has a positive effect on the quality of flour, which was verified by the baking performance of spelt flour with the baked spelt bread as an indicator of quality.

show abstract

Section: Methodsmentioning

confidence: 99%

Effect of Green Food Processing Technology on the Enzyme Activity in Spelt Flour

Leitgeb

Knez

Podrepšek

2022

Foods

Self Cite

View full text Add to dashboard Cite

show abstract

“…Similarly, a two-step spray-drying and foaming process was presented by Lee et al [118] and Nie et al [111]. Current findings on drug dissolution from polymeric carriers obtained by SC foaming in most cases has revealed prolonged release in phosphate-buffered saline (PBS), often lasting more than a month, thus showing great promise for biomedical applications [110,111,118,119].…”

Section: Sc Foamingmentioning

confidence: 96%

Supercritical Fluid Technologies for the Incorporation of Synthetic and Natural Active Compounds into Materials for Drug Formulation and Delivery

et al. 2022

Self Cite

View full text Add to dashboard Cite

Various active compounds isolated from natural sources exhibit remarkable benefits, making them attractive for pharmaceutical and biomedical applications, such as antioxidant, antimicrobial, and anti-inflammatory activities, which contribute to the treatment of cardiovascular diseases, neurodegenerative disorders, various types of cancer, diabetes, and obesity. However, their major drawbacks are their reactivity, instability, relatively poor water solubility, and consequently low bioavailability. Synthetic drugs often face similar challenges associated with inadequate solubility or burst release in gastrointestinal media, despite being otherwise a safe and effective option for the treatment of numerous diseases. Therefore, drug-eluting pharmaceutical formulations have been of great importance over the years in efforts to improve the bioavailability of active compounds by increasing their solubility and achieving their controlled release in body media. This review highlights the success of the fabrication of micro- and nanoformulations using environmentally friendly supercritical fluid technologies for the processing and incorporation of active compounds. Several novel approaches, namely micronization to produce micro- and nano-sized particles, supercritical drying to produce aerogels, supercritical foaming, and supercritical solvent impregnation, are described in detail, along with the currently available drug delivery data for these formulations.

show abstract

“…of Nimesulide with circular and uniform pores were generated at 17.0 MPa and at 35 • C. Using higher foaming temperatures did not yield foaming. Kravanja et al [312] prepared PCL-based biodegradable scaffolds incorporating bioactive calcium phosphate ceramic hydroxyapatite and different amounts of Chitosan as a biocompatible and antimicrobial agent by using supercritical CO 2 batch foaming. Foaming was triggered by a pressure drop of the high-pressurized autoclave, yielding scaffolds with improved mechanical properties and high porosity.…”

Section: Poly(ε-caprolactone) (Pcl)mentioning

confidence: 99%

Forefront Research of Foaming Strategies on Biodegradable Polymers and Their Composites by Thermal or Melt-Based Processing Technologies: Advances and Perspectives

Gonçalves,

Reis,

Fernandes

2024

Polymers

View full text Add to dashboard Cite

The last few decades have witnessed significant advances in the development of polymeric-based foam materials. These materials find several practical applications in our daily lives due to their characteristic properties such as low density, thermal insulation, and porosity, which are important in packaging, in building construction, and in biomedical applications, respectively. The first foams with practical applications used polymeric materials of petrochemical origin. However, due to growing environmental concerns, considerable efforts have been made to replace some of these materials with biodegradable polymers. Foam processing has evolved greatly in recent years due to improvements in existing techniques, such as the use of supercritical fluids in extrusion foaming and foam injection moulding, as well as the advent or adaptation of existing techniques to produce foams, as in the case of the combination between additive manufacturing and foam technology. The use of supercritical CO2 is especially advantageous in the production of porous structures for biomedical applications, as CO2 is chemically inert and non-toxic; in addition, it allows for an easy tailoring of the pore structure through processing conditions. Biodegradable polymeric materials, despite their enormous advantages over petroleum-based materials, present some difficulties regarding their potential use in foaming, such as poor melt strength, slow crystallization rate, poor processability, low service temperature, low toughness, and high brittleness, which limits their field of application. Several strategies were developed to improve the melt strength, including the change in monomer composition and the use of chemical modifiers and chain extenders to extend the chain length or create a branched molecular structure, to increase the molecular weight and the viscosity of the polymer. The use of additives or fillers is also commonly used, as fillers can improve crystallization kinetics by acting as crystal-nucleating agents. Alternatively, biodegradable polymers can be blended with other biodegradable polymers to combine certain properties and to counteract certain limitations. This work therefore aims to provide the latest advances regarding the foaming of biodegradable polymers. It covers the main foaming techniques and their advances and reviews the uses of biodegradable polymers in foaming, focusing on the chemical changes of polymers that improve their foaming ability. Finally, the challenges as well as the main opportunities presented reinforce the market potential of the biodegradable polymer foam materials.

show abstract

Transglutaminase release and activity from novel poly(ε-caprolactone)-based composites prepared by foaming with supercritical CO2

Cited by 10 publications

References 66 publications

Effect of Green Food Processing Technology on the Enzyme Activity in Spelt Flour

Effect of Green Food Processing Technology on the Enzyme Activity in Spelt Flour

Supercritical Fluid Technologies for the Incorporation of Synthetic and Natural Active Compounds into Materials for Drug Formulation and Delivery

Forefront Research of Foaming Strategies on Biodegradable Polymers and Their Composites by Thermal or Melt-Based Processing Technologies: Advances and Perspectives

Contact Info

Product

Resources

About