Transglutaminase antibodies and celiac disease in children with type 1 diabetes and in their family members

Parkkola, Anna; Härkönen, Taina; Ryhänen, Samppa J.; Uibo, Raivo; Ilonen, Jorma; Knip, Mikael

doi:10.1111/pedi.12563

Cited by 23 publications

(24 citation statements)

References 40 publications

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“…Finally, remission was more frequent among children with another autoimmune disease (thyroid or coeliac disease) present at T1D onset. The prevalence of thyroid or tissue transglutaminase autoimmunity seems to be similar to that reported in other recent publications . This finding may be surprising, but could be explained by the fact, that children with another disease remain already under medical care, and maybe these patients are diagnosed with T1D earlier, in a better condition, and with a larger amount of beta‐cells remaining.…”

Section: Discussionsupporting

confidence: 85%

“…The prevalence of thyroid or tissue transglutaminase autoimmunity seems to be similar to that reported in other recent publications. 22,23 This finding may be surprising, but could be explained by the fact, that children with another disease remain already under medical care, and maybe these patients are diagnosed with T1D earlier, in a better condition, and with a larger amount of beta-cells remaining. On the other hand, the diagnosis of a concomitant autoimmune disease preceding T1D onset points to a multiple involvement of the immune system.…”

Section: Discussionmentioning

confidence: 99%

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Remission phase in children diagnosed with type 1 diabetes in years 2012 to 2013 in Silesia, Poland: An observational study

et al. 2019

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Background/Objective The study aimed to analyze the frequency of partial remission (PR) and its association with chosen clinical and laboratory factors among pediatric patients with newly diagnosed type 1 diabetes (T1D). The long‐term effect of PR on chosen parameters was also investigated. Methods In 194 patients (95 girls) aged 8.1 ± 4.3 years, we analyzed data at T1D onset: glycemia, pH, C‐peptide, antibodies, weight, and concomitant autoimmune diseases. Anthropometric parameters, daily insulin requirement (DIR), and HbA1c 2 and 4 years after T1D diagnosis were also analyzed. We determined PR based on HbA1c and DIR measurements at least every 3 months. Results PR occurred in 59% of patients. Remitters had significantly higher pH (7.33 vs 7.28, P = 0.03), weight SD score (SDS) (0.25 vs −0.24, P = 0.002), and body mass index SDS (0.19 vs −0.66, P = 0.02) compared with non‐remitters. Concomitant diseases correlated negatively with PR. Multivariate analysis indicated only pH at onset was an independent predictor of PR. pH was the most important factor associated with the beginning of PR. There was a positive correlation between the start and duration of PR. Four years after T1D onset remitters had lower HbA1c (7.24% vs 8.05%, 53 vs 63.9 mmol/mol, P < 0.001) and DIR (0.81 vs 1.08, P = 0.005). Conclusions PR occurred quite often and developed more frequently in children with higher: weight and BMI SDS, but the main factor influencing PR presence and duration was higher pH at T1D onset. There was a beneficial impact of PR on HbA1c and DIR after 4 years of treatment.

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Section: Discussionsupporting

confidence: 85%

Section: Discussionmentioning

confidence: 99%

Remission phase in children diagnosed with type 1 diabetes in years 2012 to 2013 in Silesia, Poland: An observational study

et al. 2019

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“…Data on family history of AIDs in first- and second-degree relatives at diagnosis of the index child was attained through questionnaires [ 19 ]. For a subset of cases, additional information on AIDs within the family was compiled when a new family member was diagnosed with diabetes and registered (n = 42), or when 40% of the children (n = 710) were included in a study with a search for autoimmune thyroid disease and screening for celiac autoimmunity [ 21 ]. For the analysis of phenotype-genotype associations, the cases were grouped into phenotype categories according to the history of AIDs ( Fig 1 ): First, the children who themselves had another AID in addition to T1D, and second, the children coming from families with multiple AIDs (autoimmune families).…”

Section: Methodsmentioning

confidence: 99%

HLA and non-HLA genes and familial predisposition to autoimmune diseases in families with a child affected by type 1 diabetes

et al. 2017

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Genetic predisposition could be assumed to be causing clustering of autoimmunity in individuals and families. We tested whether HLA and non-HLA loci associate with such clustering of autoimmunity. We included 1,745 children with type 1 diabetes from the Finnish Pediatric Diabetes Register. Data on personal or family history of autoimmune diseases were collected with a structured questionnaire and, for a subset, with a detailed search for celiac disease and autoimmune thyroid disease. Children with multiple autoimmune diseases or with multiple affected first- or second-degree relatives were identified. We analysed type 1 diabetes related HLA class II haplotypes and genotyped 41 single nucleotide polymorphisms (SNPs) outside the HLA region. The HLA-DR4-DQ8 haplotype was associated with having type 1 diabetes only whereas the HLA-DR3-DQ2 haplotype was more common in children with multiple autoimmune diseases. Children with multiple autoimmune diseases showed nominal association with RGS1 (rs2816316), and children coming from an autoimmune family with rs11711054 (CCR3-CCR5). In multivariate analyses, the overall effect of non-HLA SNPs on both phenotypes was evident, associations with RGS1 and CCR3-CCR5 region were confirmed and additional associations were implicated: NRP1, FUT2, and CD69 for children with multiple autoimmune diseases. In conclusion, HLA-DR3-DQ2 haplotype and some non-HLA SNPs contribute to the clustering of autoimmune diseases in children with type 1 diabetes and in their families.

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“…Educational materials for patients and families should be made available. The prevalence of celiac disease is increased among first‐degree relatives of children with type 1 diabetes, particularly in mothers, and consequently family members of a child with newly diagnosed celiac disease should also be screened for tTG …”

Section: Growth Weight Gain and Pubertal Developmentmentioning

confidence: 99%

ISPAD Clinical Practice Consensus Guidelines 2018: Other complications and associated conditions in children and adolescents with type 1 diabetes

et al. 2018

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Transglutaminase antibodies and celiac disease in children with type 1 diabetes and in their family members

Cited by 23 publications

References 40 publications

Remission phase in children diagnosed with type 1 diabetes in years 2012 to 2013 in Silesia, Poland: An observational study

Remission phase in children diagnosed with type 1 diabetes in years 2012 to 2013 in Silesia, Poland: An observational study

HLA and non-HLA genes and familial predisposition to autoimmune diseases in families with a child affected by type 1 diabetes

ISPAD Clinical Practice Consensus Guidelines 2018: Other complications and associated conditions in children and adolescents with type 1 diabetes

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