Transgenic Targeting ofFcrlsCreates a Highly Efficient Constitutively Active Microglia Cre Line with Differentiated Specificity
Tobias Kaiser,
Jordan Dattero,
Liang Li
et al.
Abstract:Microglia carry out important functions as the resident macrophages of the brain. To study their role in health and disease, the research community needs tools to genetically modify them with maximum completeness in a manner that distinguishes them from closely related cell-types, such as monocytes. While currently available tamoxifen-inducible CreERT2 lines are able to achieve the differentiation from other cells, the field needs improved and publicly available constitutively active Cre lines, especially ones… Show more
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