Transgenic mice that express a myelin basic protein-specific T cell receptor develop spontaneous autoimmunity

MicroRNAs targeting TGFβ signalling underlie the regulatory T cell defect in multiple sclerosis

“…The MBP Ac1-11-specific TCR transgenic mice are on a B10.Pl background and were bred at the OSU animal facility (Governman et al, 1993). The ovalbumin 323-339-specific TCR transgenic mice are on a C57Bl/6 and were purchased from Jackson Laboratories.…”

Blockade of Ca2+‐activated K+ channels in T cells: an option for the treatment of multiple sclerosis?

“…It would be challenging to address the efficacy in preventing antigen-induced EAE development using different native proteins and engineered peptides fragments as well as showing efficacy in genetically modified animals exhibiting spontaneous EAE [11,12]. Also, it would be interesting to see the effects in animal models of other autoimmune diseases, such as rheumatoid arthritis, diabetes and psoriasis.…”

Mechanisms of autoimmune disease induction

“…This suggested that the presentation of MBP leading to activation of transgenic T cells was somehow augmented by colonization of the animals with normal microbial flora, or perhaps by contact with ubiquitous pathogens. In support of this idea, injection of these mice with several different bacterial products, including pertussis toxin and lipopolysaccharide, also led to an increased frequency of spontaneous develpment of EAE (18).…”