“…Somatotrope hypertrophy in mice can be caused by GHRH [60], which also increases GH secretion and synthesis [43,[61][62][63][64]. Transgenic hGHRH mice, with functional GH receptors, have larger pituitary glands because of somatotrope hyperplasia and, to some extent, somatotrope hypertrophy [25,60,65,66]. The somatotrope hypertrophy in our study was transient as there was no difference between the groups by Day 135.…”