Abstract:ObjectivePulmonary arterial hypertension (PAH) is a lethal disease, characterized by complex vascular lesions and increased pulmonary vascular resistance. To test the hypothesis that lung EC apoptosis at the level of distal pulmonary arterioles is necessary and sufficient to cause PAH phenotype we developed a novel transgenic model.Methods and ResultsThe Fas‐Induced Apoptosis (FIA) construct was expressed under the control of endothelial‐specific, Tie2 promoter in transgenic mice (i.e. EFIA mice). Two transgen… Show more
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