Transgenic Maize – The Registration Status of Lines that have Been Commercialised: The First in a Series that Examines the GM Crop Market

McLaren, James; Copping, Len

doi:10.1564/22apr07

Cited by 3 publications

(2 citation statements)

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“…Worldwide, cultivation of GM plant is growing impressively. The reduced need for application of broad-spectrum chemical pesticides, such as in the case of maize carrying Bacillus thuringiensis (Bt) insect toxin genes, is undoubtedly of great advantage [ 8 , 9 ]. Brazil achieved, for the fourth consecutive year, the largest increase in GM crop area of ~6.3 million hectares compared to 2011.…”

Section: Introductionmentioning

confidence: 99%

Endophytic microbial community in two transgenic maize genotypes and in their near-isogenic non-transgenic maize genotype

et al. 2014

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BackgroundDespite all the benefits assigned to the genetically modified plants, there are still no sufficient data available in literature concerning the possible effects on the microbial communities associated with these plants. Therefore, this study was aimed at examining the effects of the genetic modifications of two transgenic maize genotypes (MON810 – expressing the insecticidal Bt-toxin and TC1507 – expressing the insecticidal Bt-toxin and the herbicide resistance PAT [phosphinothricin-N-acetyltransferase]) on their endophytic microbial communities, in comparison to the microbial community found in the near-isogenic non-transgenic maize (control).ResultsThe structure of the endophytic communities (Bacteria, Archaea and fungi) and their composition (Bacteria) were evaluated by denaturing gradient gel electrophoresis (DGGE) and the construction of clone libraries, respectively. DGGE analysis and the clone libraries of the bacterial community showed that genotype TC1507 slightly differed from the other two genotypes. Genotype TC1507 showed a higher diversity within its endophytic bacterial community when compared to the other genotypes. Although some bacterial genera were found in all genotypes, such as the genera Burkholderia, Achromobacer and Stenotrophomonas, some were unique to genotype TC1507. Moreover, OTUs associated with Enterobacter predominated only in TC1507 clone libraries.ConclusionThe endophytic bacterial community of the maize genotype TC1507 differed from the communities of the maize genotype MON810 and of their near-isogenic parental genotypes (non-Bt or control). The differences observed among the maize genotypes studied may be associated with insertion of the gene coding for the protein PAT present only in the transgenic genotype TC1507.

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Section: Introductionmentioning

confidence: 99%

Endophytic microbial community in two transgenic maize genotypes and in their near-isogenic non-transgenic maize genotype

et al. 2014

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“…The number of countries that plant GM crops is increasing, and in particular in developing countries GM plant cultivation is growing impressively (James 2010). There are clear advantages in the utilization of GM plants in a world with limited resources and a rapidly increasing population, one of them being the reduced need for application of broad-spectrum chemical pesticides such as in the case of maize carrying Bacillus thuringiensis (Bt) insect toxin genes (McLaren and Copping 2011;Gruber et al 2012).…”

Section: Introductionmentioning

confidence: 99%

Temporal dynamics of microbial communities in the rhizosphere of two genetically modified (GM) maize hybrids in tropical agrosystems

Cotta

Dias

Marriel

et al. 2012

Antonie van Leeuwenhoek

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The use of genetically modified (GM) plants still raises concerns about their environmental impact. The present study aimed to evaluate the possible effects of GM maize, in comparison to the parental line, on the structure and abundance of microbial communities in the rhizosphere. Moreover, the effect of soil type was addressed. For this purpose, the bacterial and fungal communities associated with the rhizosphere of GM plants were compared by culture-independent methodologies to the near-isogenic parental line. Two different soils and three stages of plant development in two different periods of the year were included. As evidenced by principal components analysis (PCA) of the PCR-DGGE profiles of evaluated community, clear differences occurred in these rhizosphere communities between soils and the periods of the year that maize was cultivated. However, there were no discernible effects of the GM lines as compared to the parental line. For all microbial communities evaluated, soil type and the period of the year that the maize was cultivated were the main factors that influenced their structures. No differences were observed in the abundances of total bacteria between the rhizospheres of GM and parental plant lines.

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Transgenic maize event TC1507: Global status of food, feed, and environmental safety

Baktavachalam¹,

Delaney

Fisher

et al. 2015

GM Crops & Food

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Maize (Zea mays) is a widely cultivated cereal that has been safely consumed by humans and animals for centuries. Transgenic or genetically engineered insect-resistant and herbicide-tolerant maize, are commercially grown on a broad scale. Event TC1507 (OECD unique identifier: DAS-Ø15Ø7–1) or the Herculex®# I trait, an insect-resistant and herbicide-tolerant maize expressing Cry1F and PAT proteins, has been registered for commercial cultivation in the US since 2001. A science-based safety assessment was conducted on TC1507 prior to commercialization. The safety assessment addressed allergenicity; acute oral toxicity; subchronic toxicity; substantial equivalence with conventional comparators, as well as environmental impact. Results from biochemical, physicochemical, and in silico investigations supported the conclusion that Cry1F and PAT proteins are unlikely to be either allergenic or toxic to humans. Also, findings from toxicological and animal feeding studies supported that maize with TC1507 is as safe and nutritious as conventional maize. Maize with TC1507 is not expected to behave differently than conventional maize in terms of its potential for invasiveness, gene flow to wild and weedy relatives, or impact on non-target organisms. These safety conclusions regarding TC1507 were acknowledged by over 20 regulatory agencies including United States Environment Protection Agency (US EPA), US Department of Agriculture (USDA), Canadian Food Inspection Agency (CFIA), and European Food Safety Authority (EFSA) before authorizing cultivation and/or food and feed uses. A comprehensive review of the safety studies on TC1507, as well as some benefits, are presented here to serve as a reference for regulatory agencies and decision makers in other countries where authorization of TC1507 is or will be pursued.

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Transgenic Maize – The Registration Status of Lines that have Been Commercialised: The First in a Series that Examines the GM Crop Market

Cited by 3 publications

References 0 publications

Endophytic microbial community in two transgenic maize genotypes and in their near-isogenic non-transgenic maize genotype

Endophytic microbial community in two transgenic maize genotypes and in their near-isogenic non-transgenic maize genotype

Temporal dynamics of microbial communities in the rhizosphere of two genetically modified (GM) maize hybrids in tropical agrosystems

Transgenic maize event TC1507: Global status of food, feed, and environmental safety

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