Transgenic
            <i>Hydra</i>
            allow
            <i>in vivo</i>
            tracking of individual stem cells during morphogenesis

Wittlieb, Jörg; Khalturin, Konstantin; Lohmann, Jan U.; Anton-Erxleben, Friederike; Bosch, Thomas C. G.

doi:10.1073/pnas.0510163103

Cited by 291 publications

(258 citation statements)

References 28 publications

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“…Only one methodical problem remains, which is related to the generation of genetically manipulated animals. In principle, transgenes can be successfully introduced into the genome of all three stem cell lineages of Hydra leading to either gene knock-down by siRNA or overexpression of exogenous genes (Wittlieb et al 2006;Franzenburg et al 2012).…”

Section: The Spectrum Of Available Methods Includes the Demonstrationmentioning

confidence: 99%

Evolutionary history of the mammalian synaptonemal complex

et al. 2016

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Section: The Spectrum Of Available Methods Includes the Demonstrationmentioning

confidence: 99%

Evolutionary history of the mammalian synaptonemal complex

et al. 2016

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“…These properties are thought to be related to the fact that these animals routinely reproduce asexually (Wittlieb et al ., 2006; Khalturin et al ., 2007; Bosch, 2009; Bellantuono et al ., 2015). Three stem cell lineages allow this continuous self‐renewal: ectodermal and endodermal epitheliomuscular stem cells and interstitial stem cells (Bosch, 2009; Bosch et al ., 2010).…”

Section: Animal Modelsmentioning

confidence: 99%

Long live FOXO: unraveling the role of FOXO proteins in aging and longevity

2015

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SummaryAging constitutes the key risk factor for age‐related diseases such as cancer and cardiovascular and neurodegenerative disorders. Human longevity and healthy aging are complex phenotypes influenced by both environmental and genetic factors. The fact that genetic contribution to lifespan strongly increases with greater age provides basis for research on which “protective genes” are carried by long‐lived individuals. Studies have consistently revealed FOXO (Forkhead box O) transcription factors as important determinants in aging and longevity. FOXO proteins represent a subfamily of transcription factors conserved from Caenorhabditis elegans to mammals that act as key regulators of longevity downstream of insulin and insulin‐like growth factor signaling. Invertebrate genomes have one FOXO gene, while mammals have four FOXO genes: FOXO1, FOXO3, FOXO4, and FOXO6. In mammals, this subfamily is involved in a wide range of crucial cellular processes regulating stress resistance, metabolism, cell cycle arrest, and apoptosis. Their role in longevity determination is complex and remains to be fully elucidated. Throughout this review, the mechanisms by which FOXO factors contribute to longevity will be discussed in diverse animal models, from Hydra to mammals. Moreover, compelling evidence of FOXOs as contributors for extreme longevity and health span in humans will be addressed.

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“…after amputation [24][25][26] . Finally in both models, the cloning of targeted cDNAs together with the sequencing of ESTs and genomes definitively proved that the signaling pathways at work during programmed cell death 27-30 and development 31,32 are highly conserved and active in these two species too.…”

Section: Strengths Of the Hydra Model Systemmentioning

confidence: 99%

The Hydra model: disclosing an apoptosis-driven generator of Wnt-based regeneration

Galliot

Chera²

2010

Trends in Cell Biology

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The Hydra model system is well suited to decipher the mechanisms underlying adult regeneration, opening the possibility to characterize those that have been robust enough to be maintained across evolutionary time. The detailed analysis of the activation of the Wnt-βcatenin pathway in bisected Hydra actually shows that the route taken to regenerate a structure as complex as the head dramatically varies according to the amputation level. When decapitation induces a direct redevelopment thanks to Wnt3 signaling from the epithelial cells, head regeneration after midgastric section relies first on Wnt3 signaling from the interstitial cells that undergo apoptosis-induced compensatory proliferation and secondarily activate Wnt3 signaling in the epithelial cells. The relative distribution between stem cells and head progenitor cells is strikingly different in these two contexts indicating that the pre-amputation homeostatic conditions define and constrain the route that bridges wound healing to the re-development program of the missing structure.

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Transgenic Hydra allow in vivo tracking of individual stem cells during morphogenesis

Cited by 291 publications

References 28 publications

Evolutionary history of the mammalian synaptonemal complex

Evolutionary history of the mammalian synaptonemal complex

Long live FOXO: unraveling the role of FOXO proteins in aging and longevity

The Hydra model: disclosing an apoptosis-driven generator of Wnt-based regeneration

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