Transgenic germ cell mutation assays: A small collaborative study

Ashby, John

doi:10.1002/em.2850250102

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Dosing Considerations1

Mutations In Germ Cells Versus Somatic Cells1

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1995

1999

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Cited by 20 publications

(2 citation statements)

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“…An important, and controversial, issue in genetic toxicology, recently addressed by Ashby andLiegibel (1992, 1993) and Mirsalis (1993), is the dosing regimen, i.e., a single high dose versus repeated low doses. Long-term doses, or even relatively short-term regimens (Mirsalis et aI., 1993a), can induce cell proliferation, and thereby may increase the fixation rate of DNA lesions during mitogenesis.…”

Section: Dosing Considerationsmentioning

confidence: 99%

“…Mutation induction has been demonstrated in the Big Blue® mouse after treatment with ENU (Kohler et aI., 1991b; and the nature of the recovered mutants is consistent with proposed mechanisms of ENU mutagenesis. A study is currently under way to address issues regarding aspects of mutation in germ cells in transgenic mice (Ashby, 1995).…”

Section: Mutations In Germ Cells Versus Somatic Cellsmentioning

confidence: 99%

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