Transgenesis and Gene Edition in Mammals

Menchaca, A.; Schlapp, Geraldine; Meikle, María Noel; Crispo, Martina

doi:10.1016/b978-0-12-809633-8.09222-0

Cited by 1 publication

(2 citation statements)

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“…Although they have been used mainly in the field of genetic engineering to improve their characteristics and increase the production of milk, meat or wool, recently they have also been used as genetic models in biotechnology. The development of new genetic editing technologies that have made this technique more accessible and cheaper has further increased the interest in using these species in genetic bioengineering studies [ 7 ].…”

Section: Introductionmentioning

confidence: 99%

“…The desired proteins are collected and isolated from milk, and as such the ideal transgenic animal is one that produces large quantities of milk and has relatively short generation times, and the goat satisfies both these criteria [ 20 ]. The first drug originated from genetically modified animals and approved by the European and United States drug agencies was precisely an anticoagulant drug produced from the milk of transgenic goats (ATryn ® ) [ 7 ].…”

Section: Introductionmentioning

confidence: 99%

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Small Ruminants and Its Use in Regenerative Medicine: Recent Works and Future Perspectives

Alvites

Branquinho

Sousa

et al. 2021

Biology

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Medical and translational scientific research requires the use of animal models as an initial approach to the study of new therapies and treatments, but when the objective is an exploration of translational potentialities, classical models fail to adequately mimic problems in humans. Among the larger animal models that have been explored more intensely in recent decades, small ruminants, namely sheep and goats, have emerged as excellent options. The main advantages associated to the use of these animals in research works are related to their anatomy and dimensions, larger than conventional laboratory animals, but very similar to those of humans in most physiological systems, in addition to their low maintenance and feeding costs, tendency to be docile, long life expectancies and few ethical complications raised in society. The most obvious disadvantages are the significant differences in some systems such as the gastrointestinal, and the reduced amount of data that limits the comparison between works and the validation of the characterization essays. Despite everything, recently these species have been increasingly used as animal models for diseases in different systems, and the results obtained open doors for their more frequent and advantageous use in the future. The purpose of this review is to summarize the general principles related to the use of small ruminants as animal models, with a focus on regenerative medicine, to group the most relevant works and results published recently and to highlight the potentials for the near future in medical research.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%