Transgenerational impacts of micro(nano)plastics in the aquatic and terrestrial environment

Junaid, Muhammad; Liu, Shulin; Chen, Guanglong; Liao, Hongping; Wang, Jun

doi:10.1016/j.jhazmat.2022.130274

Cited by 38 publications

(9 citation statements)

References 131 publications

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“…Additionally, the toxic chemical additives in microplastics and/or the contaminants (e.g., persistent organic pollutants, heavy metals) that they adsorb from the surrounding seawater may leach into the animal tissues and bioaccumulate along the trophic chain [21][22][23], potentially causing harmful effects [24,25]. Several studies, mostly on marine invertebrates and fish, report direct physical harm (e.g., intestinal damage or blockage [26,27]), but also toxic effects such as growth inhibition [28,29], decreased feeding and energy reserves [30,31], decreased reproductive output [32,33], oxidative stress and immunological alterations [28,34,35], neuro-and liver toxicity [36,37], and endocrine disruption [38,39]. As most of the reported effects of microplastic ingestion result from studies performed under controlled laboratory conditions with model species from low trophic levels (e.g., crustaceans, molluscs and fishes), little is known about the consequences in the field for marine top predators [16,17,22].…”

Section: Introductionmentioning

confidence: 99%

Microplastics in Cetaceans Stranded on the Portuguese Coast

Sá,

Torres-Pereira,

Ferreira

et al. 2023

Animals

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This study characterises microplastics in small cetaceans on the coast of Portugal and assesses the relationship between several biological variables and the amount of detected microplastics. The intestines of 38 stranded dead cetaceans were processed in the laboratory, with digestion methods adapted to the amount of organic matter in each sample. The influence of several biological and health variables (e.g., species, sex, body condition) on the amount of microplastics was tested in all analysed species and particularly in common dolphins, due to the larger number of available samples. Most of the analysed individuals had microplastics in the intestine (92.11%), with harbour porpoises revealing a significantly higher median number of microplastics than common dolphins, probably due to their different diets, use of habitat and feeding strategies. None of the other tested variables significantly influenced the number of microplastics. Moreover, the microplastics found should not be enough to cause physical or chemical sublethal effects, although the correlation between microplastic ingestion and plastic additive bioaccumulation in cetacean tissues requires further investigation. Future monitoring in biota should rely on improved and standardised protocols for microplastic analyses in complex samples to allow for accurate analyses of larger samples and spatio-temporal comparisons.

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Section: Introductionmentioning

confidence: 99%

Microplastics in Cetaceans Stranded on the Portuguese Coast

Sá,

Torres-Pereira,

Ferreira

et al. 2023

Animals

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“…Nanoplastics are an emerging environmental pollution, and widely occur in global aquatic ecosystems [ 76 , 77 ]. The transgenerational effects of microplastics and nanoplastics are receiving increasing attention due to risks to the health of the offspring [ 23 ]. Exposure to the pristine PS-NP induced transgenerational toxicity in both locomotion and reproduction in C. elegans [ 37 , 41 ].…”

Section: Discussionmentioning

confidence: 99%

“…Moreover, the other adsorbed pollutants may also imply the interaction between nanoplastics and pollutants, such as the enhancement in contaminant transport [ 20 , 21 ]. Recently, the transgenerational or multigenerational toxicities of nanoplastics were further detected in Daphnia and mice [ 22 , 23 , 24 ].…”

Section: Introductionmentioning

confidence: 99%

Sulfonate-Modified Polystyrene Nanoparticle at Precited Environmental Concentrations Induces Transgenerational Toxicity Associated with Increase in Germline Notch Signal of Caenorhabditis elegans

Wang

2023

Toxics

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Recently, the transgenerational toxicity of nanoplastics has received increasing attention. Caenorhabditis elegans is a useful model to assess the transgenerational toxicity of different pollutants. In nematodes, the possibility of early-life exposure to sulfonate-modified polystyrene nanoparticle (PS-S NP) causing transgenerational toxicity and its underlying mechanisms were investigated. After exposure at the L1-larval stage, transgenerational inhibition in both locomotion behavior (body bend and head thrash) and reproductive capacity (number of offspring and fertilized egg number in uterus) was induced by 1–100 μg/L PS-S NP. Meanwhile, after exposure to 1–100 μg/L PS-S NP, the expression of germline lag-2 encoding Notch ligand was increased not only at the parental generation (P0-G) but also in the offspring, and the transgenerational toxicity was inhibited by the germline RNA interference (RNAi) of lag-2. During the transgenerational toxicity formation, the parental LAG-2 activated the corresponding Notch receptor GLP-1 in the offspring, and transgenerational toxicity was also suppressed by glp-1 RNAi. GLP-1 functioned in the germline and the neurons to mediate the PS-S NP toxicity. In PS-S NP-exposed nematodes, germline GLP-1 activated the insulin peptides of INS-39, INS-3, and DAF-28, and neuronal GLP-1 inhibited the DAF-7, DBL-1, and GLB-10. Therefore, the exposure risk in inducing transgenerational toxicity through PS-S NP was suggested, and this transgenerational toxicity was mediated by the activation of germline Notch signal in organisms.

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“…No industrial-scale treatment has been established as yet for micro- or nanoplastics. ,− PET is chemically hydrophobic; thus, it can easily adsorb hydrophobic chemicals present in soil and wastewater. These complexes could enter human bodies through the food chains.…”

Section: Introductionmentioning

confidence: 99%

Development of Enzyme-Based Approaches for Recycling PET on an Industrial Scale

Oda,

Wlodawer

2024

Biochemistry

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Pollution by plastics such as polyethylene (PE), polypropylene (PP), polyvinyl chloride (PVC), polyurethane (PUR), polyamide (PA), polystyrene (PS), and poly(ethylene terephthalate) (PET) is now gaining worldwide attention as a critical environmental issue, closely linked to climate change. Among them, PET is particularly prone to hydrolysis, breaking down into its constituents, ethylene glycol (EG) and terephthalate (TPA). Biorecycling or bioupcycling stands out as one of the most promising methods for addressing PET pollution. For dealing with pollution by the macrosize PET, a French company Carbios has developed a pilot-scale plant for biorecycling waste PET beverage bottles into new bottles using derivatives of thermophilic leaf compost cutinase (LCC). However, this system still provides significant challenges in its practical implementation. For the micro-or nanosize PET pollution that poses significant human health risks, including cancer, no industrial-scale approach has been established so far, despite the need to develop such technologies. In this Perspective, we explore the enhancement of the low activity and thermostability of the enzyme PETase to match that of LCC, along with the potential application of microbes and enzymes for the treatment of waste PET as microplastics. Additionally, we discuss the shortcomings of the current biorecycling protocols from a life cycle assessment perspective, covering aspects such as the diversity of PET-hydrolyzing enzymes in nature, the catalytic mechanism for crystallized PET, and more. We also provide an overview of the Ideonella sakaiensis system, highlighting its ability to operate and grow at moderate temperatures, in contrast to hightemperature processes.

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Transgenerational impacts of micro(nano)plastics in the aquatic and terrestrial environment

Cited by 38 publications

References 131 publications

Microplastics in Cetaceans Stranded on the Portuguese Coast

Microplastics in Cetaceans Stranded on the Portuguese Coast

Sulfonate-Modified Polystyrene Nanoparticle at Precited Environmental Concentrations Induces Transgenerational Toxicity Associated with Increase in Germline Notch Signal of Caenorhabditis elegans

Development of Enzyme-Based Approaches for Recycling PET on an Industrial Scale

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