Transgenerational epigenetics: Integrating soma to germline communication with gametic inheritance

Sharma, Abhay

doi:10.1016/j.mad.2016.12.015

Cited by 65 publications

(50 citation statements)

References 131 publications

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“…Interestingly, retrospective analysis of human subjects shows that preconception exposure of the fathers to cold temperature correlates with metabolic changes in the offspring . Given the human health and evolutionary implications of inheritance of phenotypes induced by environmental factors , the need for determining if cold can induce germline epigenetic inheritance has been emphasized . Our demonstration of male line‐mediated transgenerational epigenetic inheritance, first discovered in Drosophila a decade ago , of a cold‐induced metabolic phenotype thus provides an important lead.…”

Section: Resultsmentioning

confidence: 99%

Transgenerational inheritance of cold temperature response in Drosophila

2019

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Intergenerational inheritance of transcriptional responses induced by low temperature rearing has recently been shown in Drosophila. Besides germline inheritance, fecal transfer experiments indirectly suggested that the acquired microbiome may also have contributed to the transcriptional responses in offspring. Here, we analyze expression data on inheritance of the cold‐induced effects in conjunction with previously reported transcriptomic differences between flies with a microbiota or axenic flies and provide support for a contribution of the acquired microbiome to the offspring phenotype. Also, based on a similar analysis in conjunction with diet‐ and metabolism‐related fly transcriptome data, we predicted and, then, experimentally confirmed that cold regulates triglyceride levels both inter‐ as well as trans‐generationally.

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Section: Resultsmentioning

confidence: 99%

Transgenerational inheritance of cold temperature response in Drosophila

2019

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“…Such effects can be referred to as epigenetic transgenerational signaling. If the epigenetic alterations remain stable over several unexposed generations, then this is often referred to as epigenetic transgenerational inheritance (Jablonka & Raz (2009) ;Skinner et al (2012);Sharma (2017)). The epigenetic modifications that must be renewed each generation have profound implications for population dynamics because they provide mechanisms for maintaining species niches under the pressures of varying external forces.…”

Section: Introductionmentioning

confidence: 99%

“…The possible roles of this effect in health, disease, and aging have also been explored (Sharma (2017); Nilsson et al (2018); Safi-Stibler & Gabory (2020)). These studies have focused on semi-permanent germline modifications that can be long-lived.…”

Section: Introductionmentioning

confidence: 99%

Hypotheses and models linking epigenetic transgenerational effects to population dynamics: Exploring oscillations and applications to wildlife cycles

Juckett

2020

Preprint

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Epigenetic transgenerational mechanisms underpin the imprinting of gamete origin during reproduction in mammals but are also hypothesized to transmit environmental exposures from parents to progeny in many life forms, which could have important consequences in population dynamics. Transgenerational hypotheses embody epigenetic alterations occurring in gametes, embryonic somatic cells, and embryonic primordial germ cells because most of the epigenome is erased and reconstituted during development. Four scenarios are described in this paper encompassing somatic and germline effects where each of these is either non-propagating or propagating in time. The non-propagating effects could result from environmental impulses such as toxicants, weather, epidemics, forest fires, etc. The propagating effects could result from continuous signals such as climate variations, food web abundances, population densities, predator numbers, etc.Focusing on the propagating mode, a population growth model is constructed incorporating the intrinsic delays associated with somatic or germline effects. Each exhibit oscillatory behavior over a wide range of the parameter space due to the inherent negative feedback of such delays. The somatic (maternal) model oscillates with a period of ∼6 generations while the germline (grandmaternal) model oscillates with a period of ∼10 generations. These models can be entrained by oscillatory external signals providing that the signals contain harmonic components near the intrinsic oscillations of the models. The 10-generation oscillation of the germline-effects model is similar to many wildlife cycles in mammals, bird, and insects. The possibility that such a transgenerational mechanism is a component of these wildlife cycles is discussed.

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“…Studies over the past several decades have distinguished DNA methylation, histone modification, and non-coding RNA-based processes as the key mechanisms underlying epigenetic regulation. Epigenetic inheritance has been observed across species, including prokaryotes, plants, and animals [2][3][4][5][6][7][8], with an epigenetic trait defined as "a stably heritable phenotype resulting from changes in a chromosome without alterations in the DNA sequence" [9]. Interestingly, certain epigenetically-regulated phenotypes can propagate across multiple generations, leading to the concept of transgenerational epigenetic inheritance (TEI) [4][5][6][7][8].…”

Section: Introductionmentioning

confidence: 99%

“…TEI has been thoroughly reviewed, focusing mostly on data obtained from mammals [5,6,8,[37][38][39]. Here, such studies from Drosophila are discussed, in particular, to highlight transgenerational programming of metabolic status and longevity, and tri-methylation of histone H3 at lysine 27 (H3K27me3) as an evolutionarily conserved epigenetic mechanism underlying TEI.…”

Section: Introductionmentioning

confidence: 99%

Non-genetic Transgenerational Inheritance of Acquired Traits in Drosophila

Xia¹,

Belle²

2018

Drosophila Melanogaster - Model for Recent Advances in Genetics and Therapeutics

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It is increasingly recognized that acquired traits may be transgenerationally transmitted through non-DNA sequence-based elements, with epigenetics as perhaps the most important mechanism. Here we review examples of non-genetic transgenerational inheritance in Drosophila, highlighting transgenerational programming of metabolic status and longevity, one particular histone modification as an evolutionarily conserved underlying mechanism, and important implications of such studies in understanding health and diseases.

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Transgenerational epigenetics: Integrating soma to germline communication with gametic inheritance

Cited by 65 publications

References 131 publications

Transgenerational inheritance of cold temperature response in Drosophila

Transgenerational inheritance of cold temperature response in Drosophila

Hypotheses and models linking epigenetic transgenerational effects to population dynamics: Exploring oscillations and applications to wildlife cycles

Non-genetic Transgenerational Inheritance of Acquired Traits in Drosophila

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