Transgenerational effects of zinc in zebrafish following early life stage exposure

Zheng, Jia; Zhu, Qing–Ling; Hu, Xiu-Chuan; Parsons, D.; Lawson, Rebecca; Högstrand, Christer

doi:10.1016/j.scitotenv.2022.154443

Cited by 15 publications

(2 citation statements)

References 68 publications

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“…On the other hand, in males, nZnO was able to induce sperm ROS, causing sperm quality alterations, while in females the nZnO-induced ROS increase led to follicular growth arrest and atresia increase, finally leading to a subsequent fertility decrease caused by this contaminant in both sexes [ 174 ]. Finally, in order to evaluate the effects of Zn on sex differentiation and development, exposure of zebrafish to 650 μg/L of Zn during the first five days post fertilization (dpf) resulted in an increase in female to male ratio and hatching delay in the F0 and, interestingly, also in the progeny F1 [ 175 ]. Considering this, Zn toxicity could last after recovery from the exposure and could also affect the next generations.…”

Section: The Use Of Model Species To Investigate Reproductive Challen...mentioning

confidence: 99%

A Pretty Kettle of Fish: A Review on the Current Challenges in Mediterranean Teleost Reproduction

Lombó,

Giommi,

Zarantoniello

et al. 2024

Animals

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The Mediterranean region is facing several environmental changes and pollution issues. Teleosts are particularly sensitive to these challenges due to their intricate reproductive biology and reliance on specific environmental cues for successful reproduction. Wild populations struggle with the triad of climate change, environmental contamination, and overfishing, which can deeply affect reproductive success and population dynamics. In farmed species, abiotic factors affecting reproduction are easier to control, whereas finding alternatives to conventional diets for farmed teleosts is crucial for enhancing broodstock health, reproductive success, and the sustainability of the aquaculture sector. Addressing these challenges involves ongoing research into formulating specialized diets, optimizing feeding strategies, and developing alternative and sustainable feed ingredients. To achieve a deeper comprehension of these challenges, studies employing model species have emerged as pivotal tools. These models offer advantages in understanding reproductive mechanisms due to their well-defined physiology, genetic tractability, and ease of manipulation. Yet, while providing invaluable insights, their applicability to diverse species remains constrained by inherent variations across taxa and oversimplification of complex environmental interactions, thus limiting the extrapolation of the scientific findings. Bridging these gaps necessitates multidisciplinary approaches, emphasizing conservation efforts for wild species and tailored nutritional strategies for aquaculture, thereby fostering sustainable teleost reproduction in the Mediterranean.

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Section: The Use Of Model Species To Investigate Reproductive Challen...mentioning

confidence: 99%

A Pretty Kettle of Fish: A Review on the Current Challenges in Mediterranean Teleost Reproduction

Lombó,

Giommi,

Zarantoniello

et al. 2024

Animals

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show abstract

“…S1). Elevated concentrations of zinc are also found in virtually all lakes and rivers in dense human-populated areas (Zheng et al 2022). The high zinc concentrations in excess of 5 mg/L have been recorded in zinc-contaminated water environments, severely affecting the growth and development of aquatic life in rivers (Gozzard et al 2011).…”

Section: Introductionmentioning

confidence: 99%

Oxidative stress, neurotoxicity, and intestinal microbial regulation after a chronic zinc exposure: an experimental study on adult zebrafish (Danio rerio)

Yuan

et al. 2023

Journal of Water Reuse and Desalination

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Zinc is one of the heavy metals present in textile wastewater with high concentrations. However, the chronic toxic effects of zinc on aquatic vertebrates are still ambiguous. Zinc accumulation in zebrafish after chronic zinc exposure and toxic effects on the intestines, muscles, and gills were investigated in this study. The results showed that a significant accumulation of zinc in the intestine, muscle, and gill was observed after 25 d of zinc exposure. The toxic effects of zinc were mainly in the form of zinc-induced oxidative stress in zebrafish, potential neurotoxicity, and changes in intestinal microbes. Significant changes in the levels of superoxide dismutase, catalase, metallothionein, glutathione, and malondialdehyde indicated that zinc damaged the antioxidant system of adult zebrafish. Zinc exposure resulted in a significant decrease in acetylcholinesterase activity and abnormal neural signaling. Furthermore, zinc exposure resulted in increased intestinal microbial richness and decreased the Simpson index in adult zebrafish. At the phylum and genus levels, the predominant microbes in the intestine are altered by zinc. In summary, this study provides an analysis of the toxic effects of chronic zinc exposure on adult zebrafish and the potential mechanisms, which are important for assessing the dual effects of zinc on aquatic organisms.

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Epigenetics in Aquatic Toxicology

Hutton

Brander

2023

Epigenetics in Aquaculture

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Transgenerational effects of zinc in zebrafish following early life stage exposure

Cited by 15 publications

References 68 publications

A Pretty Kettle of Fish: A Review on the Current Challenges in Mediterranean Teleost Reproduction

A Pretty Kettle of Fish: A Review on the Current Challenges in Mediterranean Teleost Reproduction

Oxidative stress, neurotoxicity, and intestinal microbial regulation after a chronic zinc exposure: an experimental study on adult zebrafish (Danio rerio)

Epigenetics in Aquatic Toxicology

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