Transgenerational effects of early environmental insults on aging and disease incidence

Ambeskovic, Mirela; Roseboom, Tessa J.; Metz, Gerlinde A. S.

doi:10.1016/j.neubiorev.2017.08.002

Cited by 61 publications

(32 citation statements)

References 207 publications

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“…The formation of epigenetic memory is thought to be the central mechanism in transgenerational programming of disease . Epigenetic programming is a dynamic and responsive process, including chromatin remodeling, histone modifications, DNA methylation, and expression of microRNAs (miRNAs), that play a critical role in the programming of health across generations.…”

Section: Introductionsupporting

confidence: 82%

Adenomatous polyposis coli as a predictor of environmental chemical‐induced transgenerational effects related to male infertility

Yuan

Zhang

et al. 2019

J Biochem & Molecular Tox

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Exposure to toxic environmental chemicals during pregnancy is a ubiquitous threat to health with potentially transgenerational consequences. However, the underlying mechanism of how transgenerational effects occur as part of environmental chemical exposure are not well understood. We investigated the potential molecular changes associated with dibutyl phthalate exposure that induced transgenerational effects, using a rat model. Through the analysis of the Gene Expression Omnibus database, we found some similar studies of environmental exposure induced transgenerational effects. Then, we analyzed one of the studies and our results to identify the adenomatous polyposis coli (APC) gene. This gene participated the most of the pathways and was upregulated in both studies.We used the miRWALK data set to predict the microRNAs which targeted the APC gene. We confirmed the miR-30 family were significantly downregulated in F3 testis tissues and targeted the APC gene. In conclusion, the miR-30 family/APC interaction is a potential mechanism for the transgenerational effects induced by the environmental chemical.

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Section: Introductionsupporting

confidence: 82%

Adenomatous polyposis coli as a predictor of environmental chemical‐induced transgenerational effects related to male infertility

Yuan

Zhang

et al. 2019

J Biochem & Molecular Tox

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“…During youth in rats (PD21-PD35), there is little information about the stress effect on synaptic communication, especially on dendritic spine density and dendritic arbor in neurons of limbic regions. Reports from our group and other groups have shown that prenatal and postnatal stress in the rat affects the dendritic tree and dendritic spine density in limbic regions (Ambeskovic et al, 2017;Gutiérrez-Rojas et al, 2013;Íñiguez et al, 2016;Markham et al, 2013;Martínez-Téllez et al, 2009;Monroy et al, 2010;Muhammad & Kolb, 2011;Muhammad et al, 2012;Suenaga et al, 2012). For example, prenatal stress in pregnant rats caused by 2-hrs daily movement restraining from gestational day 11 until delivery caused a significant reduction in dendritic spine density in the CA1 and CA3 region of the hippocampus and nucleus accumbens (NAcc) in the offspring rats at postpubertal age (Martínez-Téllez et al, 2009).…”

Section: Introductionmentioning

confidence: 68%

Juvenile stress causes reduced locomotor behavior and dendritic spine density in the prefrontal cortex and basolateral amygdala in Sprague–Dawley rats

Pinzón-Parra

Vidal-Jiménez

Camacho-Ábrego

et al. 2018

Synapse

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Little has been investigated about the effects of stress on synaptic communication at prepubertal age, a stage considered as juvenile. This period of development is related to socialization through play. Our group has studied the changes of neuronal morphology in limbic structures caused by stress at prenatal and at early postnatal ages (before weaning) in the rat. In the present study, we assessed the effect of restraint stress at juvenile ages. Male Sprague-Dawley rats from postnatal day (PD) 21 to PD35 were restrained (from movement) for 2 hrs. Locomotor activity in a novel environment was evaluated at three different ages, prepubertal PD38, pubertal PD50, and postpubertal PD68. Using the Golgi-Cox procedure, the dendritic morphology was evaluated in the pyramidal neurons of the prefrontal cortex (PFC), hippocampus, and basolateral amygdala (BLA). Juvenile stress caused a reduced locomotor activity at PD38 and PD68 together with reduction in dendritic spines after puberty in the PFC and at all the studied ages in the BLA. In addition, dendritic length was also reduced in the PFC at PD38 and PD68 and CA1 of the ventral hippocampus at PD50 and PD68. Our results suggest that stress in the juvenile stage can cause changes at the level of behavior and synaptic communication with an effect that remains until adulthood.

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“…57 Likewise, several sexdependent transmission patterns were proposed that were mediated by parental factors, possibly stemming from epigenetic actions. 58 Such outcomes may come about owing to distress in pregnant females causing glucocorticoid changes that promote sex-dependent epigenetic actions. 59 Indeed, stressors experienced some time before pregnancy in rodents led to changes of dendritic length and spine density within brain regions associated with cognitive functioning and mood (i.e., anterior cingulate cortex and prelimbic/infralimbic cortex), primarily among male offspring.…”

Section: Discussionmentioning

confidence: 99%

Suicidal thoughts and attempts in First Nations communities: links to parental Indian residential school attendance across development

Bombay

McQuaid

Schwartz

et al. 2018

J Dev Orig Health Dis

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The Indian residential school (IRS) system in Canada ran for over a century until the last school closed in 1996. Conditions in the IRSs resulted in generations of Indigenous children being exposed to chronic childhood adversity. The current investigation used data from the 2008-2010 First Nations Regional Health Survey to explore whether parental IRS attendance was associated with suicidal thoughts and attempts in childhood, adolescence and in adulthood among a representative sample of First Nations peoples living on-reserve across Canada. Analyses of the adult sample in Study 1 (unweighted n=7716; weighted n=186,830) revealed that having a parent who attended IRS was linked with increased risk for suicidal thoughts and attempts in adolescence and adulthood. Although females were negatively affected by having a parent who attended IRS, the link with suicidal ideation in adulthood was greater for males. Analyses of the youth sample in Study 2 (unweighted n=2883; weighted n=30,190) confirmed that parental IRS attendance was associated with an increased risk for suicidal ideation and attempts. In contrast to the adult sample, parental IRS attendance had a significantly greater relation with suicidal ideation among female youth. A significant interaction also emerged between parental IRS attendance and age in the youth sample, with the influence of parental attendance being particularly strong among youth ages 12-14, compared with those 15-17 years. These results underscore the need for culturally relevant early interventions for the large proportions of Indigenous children and youth intergenerationally affected by IRSs and other collective traumas.

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Transgenerational effects of early environmental insults on aging and disease incidence

Cited by 61 publications

References 207 publications

Adenomatous polyposis coli as a predictor of environmental chemical‐induced transgenerational effects related to male infertility

Adenomatous polyposis coli as a predictor of environmental chemical‐induced transgenerational effects related to male infertility

Juvenile stress causes reduced locomotor behavior and dendritic spine density in the prefrontal cortex and basolateral amygdala in Sprague–Dawley rats

Suicidal thoughts and attempts in First Nations communities: links to parental Indian residential school attendance across development

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