Transgenerational cycle of obesity and diabetes: investigating possible metabolic precursors in cord blood from the PREOBE study

Shokry, Engy; Marchioro, Linda; Uhl, Olaf; García-Bermúdez, Mercedes; García-Santos, José Antonio; Segura, María Teresa; Campoy, Cristina; Koletzko, Berthold

doi:10.1007/s00592-019-01349-y

Cited by 10 publications

(14 citation statements)

References 37 publications

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“…later life [1][2][3]. In addition to the well-known effect of hyperglycemia, other metabolic characteristics could be of further importance for maternal and offspring health [4,5].…”

Section: Electronic Supplementary Materialsmentioning

confidence: 99%

Association between maternal triglycerides and disturbed glucose metabolism in pregnancy

et al. 2021

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Aims Dyslipidemia in pregnancy is associated with adverse pregnancy outcomes as elevated triglycerides might be considered as a risk factor for hyperglycemia and gestational diabetes. As only a few studies have addressed the association between maternal triglycerides and glucose metabolism, we aimed to explore the pathophysiologic associations of moderate hypertriglyceridemia and maternal glucose metabolism in pregnancy. Methods Sixty-seven pregnant women received a detailed metabolic characterization at 12+0–22+6 weeks of gestation by an extended 2h-75g OGTT (oral glucose tolerance test); with measurements of glucose, insulin and C-peptide at fasting and every 30 min after ingestion and assessment of triglycerides at fasting state. All examinations were repeated at 24+0–27+6 weeks of gestation. Results Elevated triglycerides in early gestation were associated with insulin resistance and β-cell dysfunction. Mean glucose concentrations during the OGTT in early pregnancy were already higher in women with hypertriglyceridemia as compared to women with triglycerides in the normal range. A higher degree of insulin resistance and increased OGTT glucose levels were also observed when metabolic assessments were repeated between 24 and 28 weeks of gestation. Of note, elevated triglycerides at early gestation were associated with development of gestational diabetes by logistic regression (odds ratio: 1.16, 95%CI: 1.03–1.34, p=0.022 for an increase of 10 mg/dl). Conclusions Hypertriglyceridemia at the start of pregnancy is closely related to impaired insulin action and β-cell function. Women with hypertriglyceridemia have higher mean glucose levels in early- and mid-gestation. Pregnant women with elevated triglycerides in early pregnancy are at increased risk of developing gestational diabetes.

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“…later life [1][2][3]. In addition to the well-known effect of hyperglycemia, other metabolic characteristics could be of further importance for maternal and offspring health [4,5].…”

Section: Electronic Supplementary Materialsmentioning

confidence: 99%

Association between maternal triglycerides and disturbed glucose metabolism in pregnancy

et al. 2021

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“…Since placental and fetal capacity to synthesize them is low, the fetus depends on the maternal supply of PUFAs [27]. Earlier studies have suggested derangements in the placental transfer and/or feto-placental metabolism of PUFAs in late pregnancy in women with GDM or obesity [28][29][30][31][32], which could contribute to the lack of benefit on offspring adiposity from increased late pregnancy n-3 PUFA intake in our study population. Similar data on the first half of pregnancy is lacking and the flux of lipids to the fetus is considerably lower at <20 weeks gestation than at term [28].…”

Section: Discussionmentioning

confidence: 81%

Macronutrient intake during pregnancy in women with a history of obesity or gestational diabetes and offspring adiposity at 5 years of age

et al. 2021

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Background/objectives The impact of maternal macronutrient intake during pregnancy on offspring childhood adiposity is unclear. We assessed the associations between maternal macronutrient intake during and after pregnancy with offspring adiposity at 5 years of age. Additionally, we investigated whether gestational diabetes (GDM), BMI, or breastfeeding modified these associations. Subjects/methods Altogether, 301 mother–child dyads with maternal prepregnancy BMI ≥ 30 and/or previous GDM participated in the Finnish Gestational Diabetes Prevention Study (RADIEL) and its 5 years follow-up. Macronutrient intakes (E%) were calculated from 3-day food records collected at 5–18 weeks’ gestation, in the third trimester, and at 12 months and 5 years after pregnancy. Offspring body fat mass (BFM) and fat percentage (BF%) at 5 years were measured by bioimpedance. Statistical analyses were multivariate linear regression. Results Mean (SD) prepregnancy BMI was 33(4) kg/m2. GDM was diagnosed in 47%. In normoglycemic women, higher first half of pregnancy n-3 PUFA intake was associated with lower offspring BFM (g) (ß −0.90; 95% CI −1.62, −0.18) and BF% (ß −3.45; 95% CI −6.17, −0.72). In women with GDM, higher first half of pregnancy n-3 PUFA intake was associated with higher offspring BFM (ß 0.94; 95% CI 0.14, 1.75) and BF% (ß 3.21; 95% CI 0.43, 5.99). Higher SFA intake in the third trimester and cumulative intake across pregnancy (mean of the first half and late pregnancy) was associated with higher BFM and BF% (across pregnancy: ß 0.12; 95% CI 0.03, 0.20 and ß 0.44; 95% CI 0.15, 0.73, respectively). Higher carbohydrate intake across pregnancy was associated with lower BFM (ß −0.044; 95% CI −0.086, −0.003), and borderline associated with BF% (ß −0.15; 95% CI −0.31, 0.00). Conclusions The macronutrient composition of maternal diet during pregnancy is associated with offspring BFM and BF% at 5 years. GDM modifies the association between prenatal n-3 PUFA intake and offspring anthropometrics.

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“…This study found that exposure to LPS during pregnancy caused changes in glycerophospholipid and fatty acid metabolites in the liver of male fetuses. In addition, glycerophospholipids, which consist of PUFA chains, are downregulated early in life and are more common in high birth weight, late obesity and diabetes (Shokry et al, 2019). Abnormal fatty acid metabolism can affect a range of other diseases, including metabolic diseases such as T2DM, inflammatory diseases, and cancer.…”

Section: Discussionmentioning

confidence: 99%

Maternal and fetal metabolomic alterations in maternal lipopolysaccharide exposure‐induced male offspring glucose metabolism disorders

Qing

Li-li

Sun

et al. 2021

Biomedical Chromatography

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Maternal lipopolysaccharide (LPS) exposure during pregnancy induces metabolic abnormalities in male offspring, but the underlying mechanisms remain unclear. The purpose of this study was to investigate the effects of maternal LPS exposure during pregnancy on metabolic profiling of maternal serum and male fetal liver using Liquid Chromatograph Mass Spectrometer techniques. From day 15 to day 17 of gestation, pregnant mice were administered intraperitoneal LPS (experimental group) (50 μg/kg/d) or saline (control group). On day 18 of gestation, maternal serum and male fetal liver were collected. After LPS exposure, levels of 38 and 75 metabolites, mainly glycerophospholipid and fatty acid metabolites, were altered in maternal serum and male fetal liver, respectively. It was found that in maternal serum and male fetal livers, the glycerophospholipids containing saturated fatty acids (SFAs) and the SFAs were upregulated, while the glycerophospholipids containing polyunsaturated fatty acids (PUFAs) and the PUFAs were downregulated. This concordance between maternal and fetal alterations in glycerophospholipid and fatty acid metabolites may be a metabolomic signature of the early intrauterine period and may provide insight into the mechanisms by which maternal LPS exposure induces disorders of glucose metabolism in male offspring.

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Transgenerational cycle of obesity and diabetes: investigating possible metabolic precursors in cord blood from the PREOBE study

Cited by 10 publications

References 37 publications

Association between maternal triglycerides and disturbed glucose metabolism in pregnancy

Association between maternal triglycerides and disturbed glucose metabolism in pregnancy

Macronutrient intake during pregnancy in women with a history of obesity or gestational diabetes and offspring adiposity at 5 years of age

Maternal and fetal metabolomic alterations in maternal lipopolysaccharide exposure‐induced male offspring glucose metabolism disorders

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