Transgenerational consequences of adolescent morphine exposure in female rats: effects on anxiety-like behaviors and morphine sensitization in adult offspring

Byrnes, Elizabeth M.

doi:10.1007/s00213-005-0122-4

Cited by 79 publications

(63 citation statements)

References 26 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Previous studies showed sex-differential behavior in the offspring of adolescent morphine-exposed rats (Byrnes, 2005;Johnson et al, 2011). Female offspring developed anxiety-like behavior, whereas male offspring demonstrated significantly enhanced morphine sensitization (Byrnes, 2005;Johnson et al, 2011). By contrast, in our study, both male and female offspring demonstrated anxiety-like behavior in the EPM and OFT procedures.…”

Section: Discussioncontrasting

confidence: 86%

“…In the present study, adult morphine exposure did not affect general parameters perhaps because the animals had reached full sexual maturity when the drug was administered. Previous studies showed sex-differential behavior in the offspring of adolescent morphine-exposed rats (Byrnes, 2005;Johnson et al, 2011). Female offspring developed anxiety-like behavior, whereas male offspring demonstrated significantly enhanced morphine sensitization (Byrnes, 2005;Johnson et al, 2011).…”

Section: Discussionmentioning

confidence: 89%

“…Adolescent maternal morphine exposure, followed by a drug-free period of several weeks, still induced anxiety-like behavior and morphine sensitization in the offspring (Byrnes, 2005). Along with behavioral changes, adolescent maternal morphine exposure also altered the response of dopamine agonists and upregulated the dopamine-and opioid-related gene in the first and second generation (Byrnes et al, 2013).…”

Section: Introductionmentioning

confidence: 98%

“…Along with behavioral changes, adolescent maternal morphine exposure also altered the response of dopamine agonists and upregulated the dopamine-and opioid-related gene in the first and second generation (Byrnes et al, 2013). However, studies of transgenerational effects of adolescent morphine exposure have primarily involved adolescent female animals (Byrnes, 2005;Byrnes et al, 2011Byrnes et al, , 2013Mei et al, 2009). The effects of adult opioid exposure on their offspring are unknown.…”

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Development of Anxiety-Like Behavior via Hippocampal IGF-2 Signaling in the Offspring of Parental Morphine Exposure: Effect of Enriched Environment

Luo

Cui

et al. 2014

Neuropsychopharmacol

View full text Add to dashboard Cite

Opioid addiction is a major social, economic, and medical problem worldwide. Long-term adverse consequences of chronic opiate exposure not only involve the individuals themselves but also their offspring. Adolescent maternal morphine exposure results in behavior and morphologic changes in the brain of their adult offspring. However, few studies investigate the effect of adult opiate exposure on their offspring. Furthermore, the underlying molecular signals regulating the intergenerational effects of morphine exposure are still elusive. We report here that morphine exposure of adult male and female rats resulted in anxiety-like behavior and dendritic retraction in the dentate gyrus (DG) region of the hippocampus in their adult offspring. The behavior and morphologic changes were concomitant with the downregulation of insulin-like growth factor (IGF)-2 signaling in the granular zone of DG. Overexpression of hippocampal IGF-2 by bilateral intra-DG injection of lentivirus encoding the IGF-2 gene prevented anxiety-like behaviors in the offspring. Furthermore, exposure to an enriched environment during adolescence corrected the reduction of hippocampal IGF-2 expression, normalized anxietylike behavior and reversed dendritic retraction in the adult offspring. Thus, parental morphine exposure can lead to the downregulation of hippocampal IGF-2, which contributed to the anxiety and hippocampal dendritic retraction in their offspring. An adolescent-enriched environment experience prevented the behavior and morphologic changes in their offspring through hippocampal IGF-2 signaling. IGF-2 and an enriched environment may be a potential intervention to prevention of anxiety and brain atrophy in the offspring of parental opioid exposure.

show abstract

Section: Discussioncontrasting

confidence: 86%

Section: Discussionmentioning

confidence: 89%

Section: Introductionmentioning

confidence: 98%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Development of Anxiety-Like Behavior via Hippocampal IGF-2 Signaling in the Offspring of Parental Morphine Exposure: Effect of Enriched Environment

Luo

Cui

et al. 2014

Neuropsychopharmacol

View full text Add to dashboard Cite

show abstract

“…The first reports that drugs may have behavioral effects beyond the exposed individual and across generations came from studies showing that offspring of males exposed to opiates, cocaine, and alcohol have increased anxiety and impaired spatial learning (Abel et al, 1989;Ledig et al, 1998;He et al, 2006). More recently, it was demonstrated that offspring of female rats exposed to morphine during adolescence have alterations in recognition memory, anxiety-like behavior, and social interaction, as well as in opiate sensitivity and tolerance (Byrnes, 2005a, b, Byrnes, 2008Byrnes et al, 2011). Interestingly, some of these effects were further transmitted to the F2 generation (Byrnes et al, 2013).…”

Section: Effect Of Stress Abused Drugs and Toxins Across Generationsmentioning

confidence: 99%

Mechanisms of Non-Genetic Inheritance and Psychiatric Disorders

Tóth

2014

Neuropsychopharmacol

View full text Add to dashboard Cite

Inheritance is typically associated with the Mendelian transmission of information from parents to offspring by alleles (DNA sequence). However, empirical data clearly suggest that traits can be acquired from ancestors by mechanisms that do not involve genetic alleles, referred to as non-genetic inheritance. Information that is non-genetically transmitted across generations includes parental experience and exposure to certain environments, but also parental mutations and polymorphisms, because they can change the parental 'intrinsic' environment. Non-genetic inheritance is not limited to the first generation of the progeny, but can involve the grandchildren and even further generations. Non-genetic inheritance has been observed for multiple traits including overall development, cardiovascular risk and metabolic symptoms, but this review will focus on the inheritance of behavioral abnormalities pertinent to psychiatric disorders. Multigenerational non-genetic inheritance is often interpreted as the transmission of epigenetic marks, such as DNA methylation and chromatin modifications, via the gametes (transgenerational epigenetic inheritance). However, information can be carried across generations by a large number of bioactive substances, including hormones, cytokines, and even microorganisms, without the involvement of the gametes. We reason that this broader definition of non-genetic inheritance is more appropriate, especially in the context of psychiatric disorders, because of the well-recognized role of parental and early life environmental factors in later life psychopathology. Here we discuss the various forms of non-genetic inheritance in humans and animals, as well as rodent models of psychiatric conditions to illustrate possible mechanisms.

show abstract

Adolescent experience affects postnatal ultrasonic vocalizations and gene expression in future offspring

Bodi

Vassoler

Byrnes

2016

Developmental Psychobiology

Self Cite

View full text Add to dashboard Cite

The present study measured postnatal ultrasonic vocalization (USV) and gene expression to examine potential changes in communication and/or attachment in the offspring of mothers exposed to morphine during adolescence. Offspring of morphine-exposed (Mor-F1), saline-exposed (Sal-F1), or non-handled control (Con-F1) female Sprague–Dawley rats were tested for separation-induced distress calls and maternal potentiation of distress calls during early postnatal development. We also examined relative expression of dopamine D2 receptor and mu opioid receptor (oprm1) mRNA in the nucleus accumbens and hypothalamus in these offspring, as their activity has been implicated in the regulation of postnatal USV in response to maternal separation. The findings indicate that adolescent experiences of future mothers, including their 10 daily saline or morphine injections, can result in significant region-specific differences in gene expression. In addition, these experiences resulted in fewer numbers of separation-induced distress calls produced by offspring. In contrast, augmented maternal potentiation was only observed in Mor-F1 offspring.

show abstract

Transgenerational consequences of adolescent morphine exposure in female rats: effects on anxiety-like behaviors and morphine sensitization in adult offspring

Cited by 79 publications

References 26 publications

Development of Anxiety-Like Behavior via Hippocampal IGF-2 Signaling in the Offspring of Parental Morphine Exposure: Effect of Enriched Environment

Development of Anxiety-Like Behavior via Hippocampal IGF-2 Signaling in the Offspring of Parental Morphine Exposure: Effect of Enriched Environment

Mechanisms of Non-Genetic Inheritance and Psychiatric Disorders

Adolescent experience affects postnatal ultrasonic vocalizations and gene expression in future offspring

Contact Info

Product

Resources

About