Transgelin: An androgen-dependent protein identified in the seminal vesicles of three Saharan rodents

Kaci-Ouchfoun, N.; Izemrane, Djamila; Boudrissa, A.; Gernigon, Thérèse; Khammar, Farida; Exbrayat, Jean-Marie

doi:10.1016/j.theriogenology.2013.06.014

Cited by 2 publications

(1 citation statement)

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“…Transgelin, also known as smooth muscle-22α, directly binds to the actin cytoskeleton and induces actin bundling to facilitate the formation of cytoskeletal structures such as stress fibers [ 22 ]. Transgelin has been shown to stabilize loose actin gels, leading to actin filament gelation.…”

Section: Discussionmentioning

confidence: 99%

Expression of Cofilin-1 and Transgelin in Esophageal Squamous Cell Carcinoma

Zhang

Liao

et al. 2015

Med Sci Monit

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BackgroundEsophageal squamous cell carcinoma (ESCC) has attracted much research attention around the world, and the number of ESCC cases has increased gradually in recent years. Identifying the specific biomarkers of ESCC is an effective approach for the early diagnosis of tumors.Material/MethodsImmunohistochemical streptavidin-peroxidase method was used to determine the expressions of Cofilin-1 and transgelin in 68 patients with esophageal squamous cell carcinoma (ESCC) and 48 individuals with normal esophageal tissues. In addition to the relationships between the expression of Cofilin-1 and transgelin, the clinicopathologic features of ESCC were also discussed. The correlation between Cofilin-1 and transgelin protein expression in ESCC was analyzed.Results(1) The positive expression rates of Cofilin-1 and transgelin were 60.3% (41/68) and 54.4% (37/68) in esophageal carcinoma tissue, respectively. The positive expression rates of Cofilin-1 and transgelin in normal esophageal tissue were 27.1% (13/48) and 29.1% (14/48), respectively. The differences were statistically significant (P<0.05). (2) The positive expression rate of Cofilin-1 did not differ significantly (P>0.05) with sex, age, ethnicity, tumor size, or infiltration depth; but did have a statistically significant (P<0.05) difference with various degrees of tumor differentiation, lymph node metastasis, and clinical stages. (3) The positive expression rate of transgelin did not differ significantly (P>0.05) with sex, age, ethnicity, tumor size, infiltration depth, and clinical stage, but did significantly (P<0.05) differ with degree of tumor differentiation and lymph node metastasis.ConclusionsCofilin-1 and transgelin may play roles in the carcinogenesis and development of esophageal squamous cell carcinoma. Cofilin-1 may be useful as an important biomarker for indicating the degree of malignancy of esophageal squamous cell carcinoma, and the detection of transgelin is valuable in early diagnosis of esophageal squamous cell carcinoma.

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Section: Discussionmentioning

confidence: 99%