Transfusion Transmissible Infections Among Voluntary Blood Donors at Dessie Blood Bank, Northeast Ethiopia: Cross-Sectional Study

Kebede, Edosa; Getnet, Gashaw; Enyew, Getie; Gebretsadik, Daniel

doi:10.2147/idr.s287224

Cited by 8 publications

(7 citation statements)

References 32 publications

(65 reference statements)

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“…These developments could be due to limited exposure to sexual education, as well as exposure to drug elicitation among the younger generation (25). Similar to study in Ghana (19), but in contrast to studies in Ethiopia (12,13,22), the named infections were more prevalent among female than male donors in our study. The relatively higher rates of TTIs among female in this study could be due to the natural anatomic limitations associated with female sexual organs, which often compromise the innate defense system (26).…”

Section: Discussionsupporting

confidence: 88%

“…The relatively higher proportion of donors age 20-29 (56.0%) was similar to studies in Ethiopia (12,13). The reasons attributed for these development included the dependency on secondary school and college students to sustain the blood banks (8,9).…”

Section: Discussionsupporting

confidence: 71%

“…In terms of blood transfusion services, the trends of blood donor population was dynamic , and observed intermitted troughs in 2014, 2015, 2017 and 2019, and intermitted peaks in 2016 and 2018 could be a reflection of limitations associated with blood banking to sustain the blood mobilization strategies (8,9). Also, the preponderance of male over female donors was also reported in number of studies across the regions in Ghana (10,11), as well as in sub-Saharan Africa (12,13) and Persian Gulf (14,15). The most cited reasons for this phenomenal low female donors included exhaustive lists of socio-cultural beliefs and clinical parameters such as menstruation cycles and maternity (8,10,11).…”

Section: Discussionmentioning

confidence: 85%

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Haemovigilance and Trends of Transfusion Transmissible Viral Infections among Asymptomatic Population at Akatsi South Municipal in Volta Region of Ghana from 2014 to 2019

Hamid

Oduro-Mensah

Adase

et al. 2022

Preprint

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Background: Tracking the changing epidemiology of Transfusion Transmissible Infections (TTIs), including Immunodeficiency virus (HIV), is critical to attaining the Sustainable Development Goals (SDG.3.3) milestones and deadlines. This study assessed the dynamics associated with Blood Donation and TTIs among blood donors at the Akatsi South Municipality in the Volta Region of Ghana. Methods: This was a haemovigilance study, designed to retrospectively evaluate secondary data on 2,588 blood donors in Akatsi South District Hospital from 2014 to 2019. Data was collected, managed and quality controlled done electronically using Microsoft Visual Basics and STATA. The trends of TTIs were determined using frequentist and descriptive statistics, and 95% confidence intervals using the Clopper Pearson test. Results: The prevalence of TTIs was 8.0%. The prevalence of HIV as well as HBV and HCV, was 3.8%, 3.2%, and 1.0% respectively. For female hosts, the prevalence was 7.4% (HIV), 4.2 % (HBV), and 1.6% (HCV). For Male-host, the rates were 3.1% (HIV), 3.5% (HBV), and 1.0% (HVC). Donors aged 15-19years were most infected at rates of 13.2% (HIV), 4.7% (HBV), and 1.9% (HCV). Conclusion: About 57(2.4%) and 3(1.2%) of 2380 blood donated were TTIs false negatives and false positives respectively. In addition to being a driver of TTIs among blood donors in this study, the HIV prevalence among teenagers was significantly above the regional and national rates. These rates have programmatic and research implications. A relatively higher sensitive blood transfusion screening method is urgently needed to prevent the transfusion of TTIs false negative blood in Akatsi Municipal Hospital

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Section: Discussionsupporting

confidence: 88%

Section: Discussionsupporting

confidence: 71%

Section: Discussionmentioning

confidence: 85%

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Haemovigilance and Trends of Transfusion Transmissible Viral Infections among Asymptomatic Population at Akatsi South Municipal in Volta Region of Ghana from 2014 to 2019

Hamid

Oduro-Mensah

Adase

et al. 2022

Preprint

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“…The present study indicated that HBV (2.95%) is the most prevalent infection among blood donors in Afghanistan. This is comparatively lower than studies from neighboring countries, India 23 (3.44%) and Pakistan 24 (3.91%), and those reported from Ethiopia 25 (4.2%). This may be attributed to the effective prevention and control mechanisms including mandatory vaccination programmes.…”

Section: Discussioncontrasting

confidence: 60%

First Report from Afghanistan on the Prevalence of Blood-Borne Infections: A Retrospective Cross-Sectional Multicentre Study for an Epidemiological Assessment

Hashemi¹,

Waheed²,

Saba³

et al. 2022

JBM

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Background The transfusion of blood and blood components has a significant role in healthcare services. However, it remains a possible risk factor for blood-borne infections. The present study was conducted to assess the prevalence of serological markers of common blood-borne infections among the blood donor population of Afghanistan. Methodology This was a cross-sectional study based on retrospectively collected data over a period of six years from 284 blood centres across 34 provinces of Afghanistan. Every blood donor’s sample was tested by rapid immunoassays for the serological markers of blood-borne infections namely hepatitis B surface antigen (HBsAg), anti-hepatitis C virus (anti-HCV), anti-human immunodeficiency virus 1/2 (anti-HIV1/2), and anti-Treponema pallidum (anti-TP). Results All blood donors during the study period were males. The majority of blood donations were from the family replacement category 56.93% (n = 544,568). The overall pooled prevalence of blood-borne infections was 4.36% with a comparatively higher percentage in family replacement donors 4.88%. The seropositivity for HBsAg, anti-HCV, anti-HIV1/2, and anti-TP was 2.95%, 0.81%, 0.04%, and 0.54%, respectively. Conclusion Complete reliance on voluntary blood donors and screening with quality assured highly sensitive assay is recommended to ensure blood safety in the country.

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“…The residual risk of HIV is a problem that daily threatens the safety of donation in all blood banks around the world. The transmission of transfusion-transmissible infections (TTIs) remains a real problem in transfusion settings around the world [ 1 – 5 ].…”

Section: Introductionmentioning

confidence: 99%

Genetic diversity of the human immunodeficiency virus of type 1 in Gabonese transfusional settings

et al. 2023

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Background The high endemicity of transfusion-transmissible infections (TTIs) in sub-Saharan Africa is a real public health problem. To reduce the risk of HIV transmission through blood donation, the NBTC of Gabon has launched in recent years a reorganization of its blood transfusion system. This study aims to characterize the molecular strains of HIV-1 circulating in donors and to estimate the risk of viral transmission. Materials and methods A cross-sectional study was carried out during the period from August 2020 to August 2021 among 381 donors who had agreed to donate blood at the National Blood Transfusion Center (NBTC). Viral load was determined by Abbott Real-Time (Abbott m2000®, Abbott) and sequencing by the Sanger method (ABI 3500 Hitachi®). The phylogenetic tree was constructed by MEGA X software. Data were checked, entered, and analyzed using SPSS version 21.0 software, with p ≤ 0.05 considered statistically significant. Results A total of 381 donors were enrolled in the study. Among the 359 seronegative donors, five (5) seronegative donors were detected positive for HIV-1 using Real-Time PCR. The residual risk was 648 per 1,000,000 donations. The prevalence of residual infection was 1.4% [0,01; 0,03]. Sixteen (16) samples were sequenced. The strains obtained were CRF02_AG (50%), subtype A1 (18.8%), subtype G (12.5%), CRF45_cpx (12.5%) and subtype F2 (6.2%). Six sequences clustered with A1, G, CRF02_AG, and CRF45_cpx subtypes. Conclusion The residual risk of HIV-1 transmission by blood transfusion remains a concern in the Gabonese transfusional settings. A policy based on improving the current screening strategy would involve the implementation of the nucleic acid test (NAT) in order to optimize the safety of the donation by detecting the HIV-1 subtypes in circulation in the donors.

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Transfusion Transmissible Infections Among Voluntary Blood Donors at Dessie Blood Bank, Northeast Ethiopia: Cross-Sectional Study

Cited by 8 publications

References 32 publications

Haemovigilance and Trends of Transfusion Transmissible Viral Infections among Asymptomatic Population at Akatsi South Municipal in Volta Region of Ghana from 2014 to 2019

Haemovigilance and Trends of Transfusion Transmissible Viral Infections among Asymptomatic Population at Akatsi South Municipal in Volta Region of Ghana from 2014 to 2019

First Report from Afghanistan on the Prevalence of Blood-Borne Infections: A Retrospective Cross-Sectional Multicentre Study for an Epidemiological Assessment

Genetic diversity of the human immunodeficiency virus of type 1 in Gabonese transfusional settings

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