Transfusion to Bone Marrow or Solid Organ Transplant Recipients

Kaufman, Richard M.; Sloan, Steven R.

doi:10.1016/b978-0-443-06981-9.50044-2

Cited by 1 publication

(2 citation statements)

References 169 publications

(145 reference statements)

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“…Plasma depletion of SCT product may help in prevention (42). In addition, minor ABO mismatches may result in the passenger lymphocyte syndrome, in which recipients develop severe and even fatal hemolytic anemia one to three weeks after SCT (42, 43, 45). This condition is similar to TA-GVHD, though in passenger lymphocyte syndrome it is passenger B cells which proliferate within the recipient and generate anti-A or anti-B antibodies.…”

Section: Stem Cell Transplant Patientsmentioning

confidence: 99%

“…The DAT is typically positive, though this may be delayed until several days after hemolysis begins. Conversely some recipients of minor ABO mismatch SCT may develop a positive DAT without significant hemolysis(42, 46). Passenger lymphocyte syndrome occurs in up to approximately 15% of minor or bidirectional mismatch SCT(47, 48).…”

Section: Stem Cell Transplant Patientsmentioning

confidence: 99%

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Transfusion medicine problems and solutions for the pediatric hematologist/oncologist

Luban

McBride

Ford

et al. 2012

Pediatric Blood & Cancer

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Blood component transfusion is an integral part of the care of children with oncologic and hematologic conditions. The complexity of transfusion medicine may however lead to challenges for pediatric hematologists/oncologists. In this review, three commonly encountered areas of transfusion medicine are explored. The approach to the investigation and management of suspected platelet refractoriness is reviewed. The unique transfusion related challenges encountered by children undergoing stem cell transplantation are also discussed. Finally, issues arising out of the care of children with hemoglobinopathies are explored, with an emphasis on the incidence of allo- and autoimmunization.

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