Transfusion support for patients with sickle cell disease

Wallace, Lisa R.; Thibodeaux, Suzanne R.

doi:10.1016/j.transci.2022.103556

Cited by 4 publications

(4 citation statements)

References 37 publications

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“…The cornerstone of treatment in ACS involves the use of supportive measures that address its multifactorial etiology: antibiotics, supplemental oxygenation, rehydration, and simple or red cell exchange transfusion [10]. Red cell exchange transfusion aims to minimize the amount of hemoglobin S, thereby increasing oxygenation and preventing further complications relating to poor oxygenation [11] Given the paucity of randomized controlled studies, the decision to use blood transfusion in ACS is usually left to the discretion of the clinician [1]. Similarly, there are no clear guidelines about the use of red cell exchange transfusion in the treatment of ACS complicated by acute right ventricular failure.…”

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

“…Nevertheless, it would have been advantageous to obtain data from a right heart catheterization to determine if there was an elevation in pulmonary hypertension during the acute chest syndrome, which led to an acute increase in right ventricular afterload and subsequent right ventricular failure. Furthermore, although explaining how red cell exchange transfusion improves right ventricular dysfunction in acute chest syndrome is not the main focus of this case report, it's possible that this is because red cell exchange transfusion reduces the quantity of Hemoglobin S, which in turn enhances oxygenation resulting in reduced pulmonary vasoconstriction [ 11 ].…”

Section: Discussionmentioning

confidence: 99%

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A Case of Right Ventricular Failure Secondary to Acute Chest Syndrome Managed With Early Red Cell Exchange Transfusion

Geletu¹,

Emole²,

Sayf³

et al. 2023

Cureus

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Patients with sickle cell disease are at risk of vaso-occlusive crises including acute chest syndrome (ACS) and pulmonary hypertension. ACS is a life-threatening complication of sickle cell disease and is associated with increased morbidity and mortality. It is known that pulmonary pressures increase during episodes of acute chest syndrome and may lead to acute right ventricular failure leading to increased morbidity and mortality. Given the paucity of randomized controlled trials, the management of ACS and pulmonary hypertension in the setting of a sickle cell crisis largely relies on expert opinion. We present a case of acute chest syndrome complicated by acute right ventricular failure that was managed with prompt red cell exchange transfusion with favorable clinical outcomes.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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A Case of Right Ventricular Failure Secondary to Acute Chest Syndrome Managed With Early Red Cell Exchange Transfusion

Geletu¹,

Emole²,

Sayf³

et al. 2023

Cureus

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“…Anaemia is a widely observed nutritional deficiency among pregnant women on a global scale (Bhadra and Deb, 2020). Anaemia, a condition marked by a reduction in red blood cells or haemoglobin (Hb), has the potential to negatively impact both the mother and the developing foetus (Wallace and Thibodeaux, 2022). Iron deficiency is a prevalent condition among women of reproductive age globally, contributing to almost half of all cases of anaemia (Stevens et al, 2013).…”

Section: Introductionmentioning

confidence: 99%

Dietary diversity and preferences among pregnant women and its association with anaemia

Twum - Dei,

Aryeetey,

Aduku

2024

NFS

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Purpose This study aims to assess dietary choices of pregnant women and its relationship with their anaemia status. Design/methodology/approach A mixed-method study comprising a survey and three focus group discussions (FGDs). The survey included 380 adult pregnant women with data collected on food choices, preferences and haemoglobin (Hb) status. Findings More than 50% of women in the study had Hb concentration < 11.0 g/dl; mean Hb was 10.24 g/dl (SD = 1.59). Univariate analysis was used to generate descriptive tabulations for socio-demographic characteristics of respondents, dietary choices for women and anaemia status. T-test and bivariate analysis between dietary diversity score of the women among the food groups consumed as well as their anaemia (Hb) status. This showed that women with high dietary diversity score had improved Hb status (P = 0.003), and those who consumed meat and fish as well as dark leafy vegetables had significantly high diversity scores (P = 0.031 and P = 0.049). Thematic analysis was used for analysing qualitative data. Research limitations/implications The sample used in the study is unlikely to be fully representative of pregnant women in the Accra Metropolis. In addition, this study used a cross-sectional study design, making it difficult to establish causal associations between nutritional status and food choice of pregnant women. It does not also show variation in dietary practices by seasons of the year. The scope of the study did not allow for a detailed analysis, and this should be considered in future studies. Also, the study did not explore an obstetric factor like past bleeding history as well as the menstrual cycle of these pregnant women, as these factors are likely to interfere with the anaemia status of the pregnant women. Originality/value This paper contributes significant value by specifically focusing on and clarifying the complex relationship between dietary choices and aneamia among pregnant women. It also provides insights into the distinct dietary patterns and preferences of pregnant women, which may be contributing to the high prevalence of aneamia. The results of the study can inform the development of localized, evidence-based interventions to address this critical public health concern, ultimately leading to improved maternal and foetal health outcomes.

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Modification of deglycerolization procedure improves processing and post-thaw quality of cryopreserved sickle trait red cell concentrates

Phan,

Kurach,

Foxcroft

et al. 2024

Cryobiology

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Transfusion support for patients with sickle cell disease

Cited by 4 publications

References 37 publications

A Case of Right Ventricular Failure Secondary to Acute Chest Syndrome Managed With Early Red Cell Exchange Transfusion

A Case of Right Ventricular Failure Secondary to Acute Chest Syndrome Managed With Early Red Cell Exchange Transfusion

Dietary diversity and preferences among pregnant women and its association with anaemia

Modification of deglycerolization procedure improves processing and post-thaw quality of cryopreserved sickle trait red cell concentrates

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