2020
DOI: 10.1016/j.clp.2020.02.002
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Transfusion-related Gut Injury and Necrotizing Enterocolitis

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Cited by 14 publications
(15 citation statements)
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“…The background of this pathophysiological process remains elusive, as patients with severe NEC might develop bleeding and anemia and, therefore, require RBC transfusions. Moreover, larger meta-analyses were not able to confirm this association [28]. We included RBC transfusion up until 5 days before diagnosis of NEC in our analysis, and we confirmed that RBC transfusions were independently associated with Bell stage III, but did not further investigate the underlying processes.…”
Section: Discussionmentioning
confidence: 79%
“…The background of this pathophysiological process remains elusive, as patients with severe NEC might develop bleeding and anemia and, therefore, require RBC transfusions. Moreover, larger meta-analyses were not able to confirm this association [28]. We included RBC transfusion up until 5 days before diagnosis of NEC in our analysis, and we confirmed that RBC transfusions were independently associated with Bell stage III, but did not further investigate the underlying processes.…”
Section: Discussionmentioning
confidence: 79%
“…Preterm infants who develop transfusion-associated NEC are at a higher risk of mortality, and surgical NEC is more prevalent following PRBC transfusion [ 19 , 20 , 21 ]. Furthermore, recent data suggest that severe anemia may influence the risk of gut injury [ 22 ]; therefore, following care approaches such as delayed cord clamping and reducing blood loss due to phlebotomy are suggested [ 23 ]. In our study, the incidence of confirmed NEC was significantly lower in the study group compared to the control group.…”
Section: Discussionmentioning
confidence: 99%
“…Herein, we proposed that anemia, rather than blood transfusion, increased the risk of NEC occurrence in patients without sepsis because anemia damages splanchnic perfusion and causes hypoxia, anaerobic metabolism, and accumulation of anaerobic metabolism products, such as lactic acids. These by-products disrupt the intestinal vascular regulation and result in ischemic injury, thereby increasing the risk of NEC occurrence 35 . Various microbes causing sepsis give rise to anemia, hypoxia, and intestinal tissue damage in the body, and hence, are deemed as confounding factors that complicate the analysis of the results.…”
Section: Correlation Between Plt Activation Indicators and Nec Occurrencementioning
confidence: 99%