Transfusion Related Acute Lung Injury (TRALI) Caused by Red Blood Cell Transfusion Involving Residual Plasma Anti‐HLA Antibodies: A report on two Cases and General Considerations

Odent-Malaure, Hélène; Quainon, Fabienne; Ruyer-Dumontier, Pascale; Ducroz, Soizick; Verdier, Philippe; Voitellier, Evelyne; Raynal, Marie-Françoise; Fromont, Patricia; Muller, Jean‐Yves; Rebibo, Danielle; Absi, Léna; Garraud, Olivier

doi:10.1080/17402520500307926

Cited by 15 publications

(10 citation statements)

References 24 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…PRCs are the LBP less at risk. However, because they are transfused most frequently, they are involved in one third of TRALI cases [14]. These results are in the same range as those recently presented for Canada [13].…”

Section: Discussionsupporting

confidence: 79%

Epidemiology of Transfusion Related Acute Lung Injury in France: Preliminary Results

Renaudier

Schlanger²,

Vo³

et al. 2008

Transfus Med Hemother

Self Cite

View full text Add to dashboard Cite

The French Hemovigilance Network has been established in 1994 and records all adverse events associated with the transfusion of a labile blood products (LBP) regardless of their severity. From 1994 to 2006 35,423,172 LBP were issued, 85,812 adverse transfusion reactions notified, and 139 cases of transfusion related acute lung injury (TRALI) observed. The LBP most at risk is fresh frozen plasma (FFP), followed by platelets concentrates (PC) and packed red cells (PRC). However, because the use of FFP is not frequent in France, it only accounts for about 10% of TRALI, whereas PRC and PC are involved in the remaining cases. In no case, pooled FFP treated with solvent-detergent were involved. Patients’ profiles are peculiar with a high disease burden. Therefore, targeting a prevention policy only on FFP would result in a marginal reduction of TRALI in France.

show abstract

Section: Discussionsupporting

confidence: 79%

Epidemiology of Transfusion Related Acute Lung Injury in France: Preliminary Results

Renaudier

Schlanger²,

Vo³

et al. 2008

Transfus Med Hemother

Self Cite

View full text Add to dashboard Cite

show abstract

“…There is no clear definition or threshold separating low plasma volume versus high plasma volume and while the volume of plasma transfused is undoubtedly relevant, the alloantibody titer or avidity and the clinical circumstances of the patient may be equally relevant regarding the occurrence of this reaction . There have been several reports addressing the issues of RBC‐associated TRALI and female donors,21‐23 antibody detection and specificity in female donors, and the relevance of antibody strength . RBC‐associated TRALI has been observed in isolated case reports, cardiac surgery, and critically ill patients .…”

Section: Discussionmentioning

confidence: 99%

Residual plasma in red blood cells and transfusion‐related acute lung injury

2014

View full text Add to dashboard Cite

show abstract

“…In addition, given the high rate of transfusion, providers should be prepared to manage rare but serious transfusion-related sequelae such as hemolytic reactions, transfusion-related acute lung injury, and transfusion-related immune reactions. 36–38 …”

Section: Discussionmentioning

confidence: 99%

The Impact of Perioperative Packed Red Blood Cell Transfusion on Survival in Epithelial Ovarian Cancer

Warner

Dowdy²,

Martin

et al. 2013

Int J Gynecol Cancer

View full text Add to dashboard Cite

Objective Perioperative packed red blood cell transfusion (PRBCT) has been implicated as a negative prognostic marker in surgical oncology. There is a paucity of evidence on the impact of PRBCT on outcomes in epithelial ovarian cancer (EOC). We assessed whether PRBCT is an independent risk factor of recurrence and death from EOC. Methods Perioperative patient characteristics and process-of-care variables (defined by the National Surgical Quality Improvement Program) were retrospectively abstracted from 587 women who underwent primary EOC staging between January 2, 2003, and December 29, 2008. Associations with receipt of PRBCT were evaluated using univariate logistic regression models. The associations between receipt of PRBCT and disease-free survival and overall survival were evaluated using multivariable Cox proportional hazards models and using propensity score matching and stratification, respectively. Results The rate of PRBCT was 77.0%. The mean ± SD units transfused was 4.1 ± 3.1 U. In the univariate analysis, receipt of PRBCT was significantly associated with older age, advanced stage (≥IIIA), undergoing splenectomy, higher surgical complexity, serous histologic diagnosis, greater estimated blood loss, longer operating time, the presence of residual disease, and lower preoperative albumin and hemoglobin. Perioperative packed red blood cell transfusion was not associated with an increased risk for recurrence or death, in an analysis adjusting for other risk factors in a multivariable model or in an analysis using propensity score matching or stratification to control for differences between the patients with and without PRBCT. Conclusions Perioperative packed red blood cell transfusion does not seem to be directly associated with recurrence and death in EOC. However, lower preoperative hemoglobin was associated with a higher risk for recurrence. The need for PRBCT seems to be a stronger prognostic indicator than the receipt of PRBCT.

show abstract

Transfusion Related Acute Lung Injury (TRALI) Caused by Red Blood Cell Transfusion Involving Residual Plasma Anti‐HLA Antibodies: A report on two Cases and General Considerations

Cited by 15 publications

References 24 publications

Epidemiology of Transfusion Related Acute Lung Injury in France: Preliminary Results

Epidemiology of Transfusion Related Acute Lung Injury in France: Preliminary Results

Residual plasma in red blood cells and transfusion‐related acute lung injury

The Impact of Perioperative Packed Red Blood Cell Transfusion on Survival in Epithelial Ovarian Cancer

Contact Info

Product

Resources

About