Transfusion‐related acute lung injury: a neglected, serious complication of hemotherapy

Popovsky, Mark; Chaplin, Hugh; Moore, S. Breanndan

doi:10.1046/j.1537-2995.1992.32692367207.x

Cited by 237 publications

(203 citation statements)

References 17 publications

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“…However, TRALI is underdiagnosed and under-reported. 15,16 Cases remain unnoticed or are misdiagnosed as fluid overload or acute lung injury (ALI) of other etiology. 15,17,18 As yet, controlled trials using standardized definitions of TRALI are limited.…”

Section: Introductionmentioning

confidence: 99%

The incidence, risk factors, and outcome of transfusion-related acute lung injury in a cohort of cardiac surgery patients: a prospective nested case-control study

Vlaar

Hofstra²,

Determann³

et al. 2011

Blood

188

176

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Section: Introductionmentioning

confidence: 99%

The incidence, risk factors, and outcome of transfusion-related acute lung injury in a cohort of cardiac surgery patients: a prospective nested case-control study

Vlaar

Hofstra²,

Determann³

et al. 2011

Blood

188

176

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“…There is also a relationship between platelet age and TRALI. Antileukocyte antibodies, activation of the compleman cascade, neutrophil (PMN)-mediated lung injury and pulmonary leukostasis are responsible for the pathogenesis of TRALI [6][7][8]. Furthermore, IL-6 and IL-8 are essential cytokines which stimulate PMN and play important role in pathogenesis of TRALI [9,10].…”

Section: Discussionmentioning

confidence: 99%

Transfusion-Related Acute Lung Injury

Teke

Behret

Teke

2012

Indian J Hematol Blood Transfus

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Transfusion-related acute lung injury (TRALI) is related to the transfusion of blood components. Typically, it is a clinical syndrome, characterized by the sudden onset of dyspnea, hypoxemia and bilateral non-cardiogenic pulmonary edema. A 83-year-old female patient with a history of AML developed TRALI after receiving 6 units of platelets. TRALI symptoms was started 10 min later the transfusion. AML is a risky group for TRALI. While giving transfusion to the risky groups of TRALI one must be more careful. The mortality rate caused by TRALI will decrease if the patient who is thought to have TRALI or who has bilateral pulmonary edema without any other reason showing the existance of TRALI is given ventilatory support at the right time.

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“…The wide range of reported TRALI incidence rates (5,17,18,23) can be attributed to different definitions used in studies or surveillance systems, different diagnostic criteria, different quality of denominator data used (eg, components issued versus products transfused) and, most importantly, whether the rates were derived from prospective studies or from surveillance systems; in the latter case, the rates vary according to the characteristics of the surveillance system. Between 1996 and 2005, the Serious Hazards of Transfusion (SHOT) hemovigilance system has analysed 3239 reports of adverse reactions and events associated with transfusion in the United Kingdom (25).…”

Section: Discussionmentioning

confidence: 99%

“…Based on TRALI incidence in adults (17,23), combined with estimates from paediatric population statistics and Quebec data on paediatric transfusion frequency (24), 20 paediatric cases of TRALI were expected annually. To obtain reasonably narrow CIs and to accurately characterize patients and describe treatment and outcome, it was determined that 40 cases of paediatric TRALI should be identified.…”

Section: Incidence Of Tralimentioning

confidence: 99%