Transfusion Reactions

Savage, William

doi:10.1016/j.hoc.2016.01.012

Cited by 47 publications

(46 citation statements)

References 84 publications

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“…The incidence of other serious transfusion reactions was difficult to accurately estimate due to their low levels of apparent occurrence, which was not unexpected given our moderate sample size. Minor reactions (febrile and allergic), which were not targeted for intensive investigation in this study, occurred in 0.62 and 0.29% of all analyzed transfusion episodes; these rates are lower than the 1% (febrile) and 1% to 3% (allergic) rates historically described …”

Section: Discussioncontrasting

confidence: 57%

Incidence of transfusion reactions: a multicenter study utilizing systematic active surveillance and expert adjudication

et al. 2016

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Background Prevalence estimates of serious hazards of transfusion vary widely. We hypothesized that the current reporting infrastructure in the United States fails to capture many transfusion reactions, and undertook a multi-center study utilizing active surveillance, data review, and adjudication to test this hypothesis. Study Design and Methods A retrospective record review was completed for a random sample of 17% of all inpatient transfusion episodes over 6 months at 4 academic tertiary care hospitals, with an episode defined as all blood products released to a patient in 6 hours. Data were recorded by trained clinical research nurses, and serious reactions were adjudicated by a panel of transfusion medicine experts. Results Of 4857 transfusion episodes investigated, 1.1% were associated with a serious reaction. Transfusion associated circulatory overload (TACO) was the most frequent serious reaction noted, being identified in 1% of transfusion episodes. Despite clinical notes describing a potential transfusion association in 59% of these cases, only 5.1% were reported to the transfusion service. Suspected transfusion related acute lung injury (TRALI/possible TRALI), anaphylactic, and hypotensive reactions were noted in 0.08%, 0.02%, and 0.02% of transfusion episodes. Minor reactions, including febrile non-hemolytic and allergic, were noted in 0.62% and 0.29% of transfusion episodes, with 30–50% reported to the transfusion service. Conclusion Underreporting of cardiopulmonary transfusion reactions is striking among academic, tertiary care hospitals. Complete and accurate reporting is essential to identify, define, establish pathogenesis, and mitigate/treat transfusion reactions. A better understanding of the failure to report may improve the accuracy of passive reporting systems.

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Section: Discussioncontrasting

confidence: 57%

Incidence of transfusion reactions: a multicenter study utilizing systematic active surveillance and expert adjudication

et al. 2016

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“…Besides, we decided to transfuse only one component in the morning, and if the patient needed an additional transfusion, this would be done in the afternoon. The tranquil home environment could potentially help avoid identification errors or detect alarm signs, while transfusing only 1 unit per day can help reduce the risk of circulatory overload…”

Section: Discussionmentioning

confidence: 99%

Home transfusion: three decades of practice at a tertiary care hospital

et al. 2018

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“…These treatments are associated with both immune and nonimmune reactions due at least in part to contaminating white blood cells (WBCs). 1 Despite improved donor screening and implementation of safety procedures, bacterial contamination of PLT concentrates (PCs) still represents a major infectious risk. 2,3 Most transfusion-transmissible infectious agents as well as donor WBCs can be inactivated by pathogen inactivation (PI) technologies.…”

Section: Discussionmentioning

confidence: 99%

“…Platelet (PLT) transfusions continue to be vital for treating patients with qualitative and quantitative PLT disorders. These treatments are associated with both immune and nonimmune reactions due at least in part to contaminating white blood cells (WBCs) . Despite improved donor screening and implementation of safety procedures, bacterial contamination of PLT concentrates (PCs) still represents a major infectious risk .…”

mentioning

confidence: 99%