Abstract:2327
Background:
Transfusion of human blood stored for over 2 weeks is associated with increased mortality and morbidity. During storage, packed red blood cells (PRBC) progressively release hemoglobin, which avidly binds nitric oxide (NO). We hypothesized that the NO mediated hyperemic response following ischemia would be reduced after transfusion of PRBC stored for 40 days.
Methods and results:
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