Transfusion of polymerised human haemoglobin in a patient with severe sickle-cell anaemia

Raff, J; Dobson, Cassandra; Tsai, Han‐Mou

doi:10.1016/s0140-6736(02)09640-x

Cited by 17 publications

(7 citation statements)

References 4 publications

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“…This benefit was demonstrated in prior clinical experience with PolyHeme in hospitalized patients 26–28,48,49,52,74 and in multiple emergency, compassionate treatments. 75,77,78 The results from this study suggest some increase in frequency of AEs compared with the use of blood. Consequently, PolyHeme would not be used interchangeably with RBCs but would be used when the likelihood of dying without oxygen-carrying replacement is so great that the potential life-sustaining benefit would exceed any potential risks.…”

Section: Clinical Implications Of the Phase III Prehospital Hboc Resumentioning

confidence: 61%

The USA Multicenter Prehosptial Hemoglobin-based Oxygen Carrier Resuscitation Trial: Scientific Rationale, Study Design, and Results

Moore

Johnson

Moore

et al. 2009

Critical Care Clinics

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The current generation of blood substitutes tested in clinical trials are red blood cell (RBC) substitutes; that is, they are designed primarily to transport oxygen. The products now being used in advanced-phase clinical trials are derived from hemoglobin (Hb) and are thus often referred to as Hb-based oxygen carriers (HBOCs). The potential benefits of HBOCs are well known (Box 1). The objectives of this overview are to provide the scientific background and rationale for the study design of the USA Multi-center Prehospital HBOC Resuscitation Trial and to present the results and discuss clinical implications. Potential clinical benefits of hemoglobin-based oxygen carriers in trauma careAvailabilityAbundant supplyUniversally compatibleProlonged shelf-lifeStorage at room temperatureSafetyNo disease transmissionsNo antigenic reactionsNo immunologic effectsEfficacyEnhanced oxygen deliveryImproved rheologic properties

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Section: Clinical Implications Of the Phase III Prehospital Hboc Resumentioning

confidence: 61%

The USA Multicenter Prehosptial Hemoglobin-based Oxygen Carrier Resuscitation Trial: Scientific Rationale, Study Design, and Results

Moore

Johnson

Moore

et al. 2009

Critical Care Clinics

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“…15 In another study, 16 the transfusion of human haemoglobin solution resulted in an increased haemoglobin concentration and increased oxygen delivery and pain relief in a sickle cell patient in crisis. This study highlights the role of improved oxygen delivery in pain relief during sickle cell crisis.…”

Section: Discussionmentioning

confidence: 98%

Oxygen delivery index in homozygous sickle cell disease: steady and crisis states

Bowers

Pepple

Reid

2009

British Journal of Biomedical Science

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One of the common complications of sickle cell disease is the vaso-occlusive crisis or sickle cell crisis which could result in impaired oxygen delivery to the tissues. This study investigates the oxygen delivery index (ODI) in 38 patients with homozygous sickle cell anaemia. Thirty-three patients were in the steady state and five were experiencing crisis at the time of recruitment. Whole blood viscosity was measured with a Wells Brookfield viscometer at a shear rate of 230 sec(-1) and haematocrit was measured with an AC Tron Coulter Counter. The ODI, which is an indirect measure of the capacity of blood to deliver oxygen to tissues, was calculated as the ratio of haematocrit to whole blood viscosity values. There was no statistically significant difference in the ODI between the steady and crisis states, suggesting that tissue oxygenation is not the only factor involved in the sickle cell crisis.

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“…In lieu of compatible RBC-concentrates, the authors infused five doses of polymerized human Hb (PolyHeme TM ). This treatment in combination with erythropoetin, resulted in a sustained increase of Hb-concentration and finally in the patient's recovery [80].…”

Section: Use As a Transfusion Alternative In Hematological Disordersmentioning

confidence: 91%

Blood Substitutes

Pape¹,

Häbler²

2010

Tissue Engineering

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Transfusion of polymerised human haemoglobin in a patient with severe sickle-cell anaemia

Cited by 17 publications

References 4 publications

The USA Multicenter Prehosptial Hemoglobin-based Oxygen Carrier Resuscitation Trial: Scientific Rationale, Study Design, and Results

The USA Multicenter Prehosptial Hemoglobin-based Oxygen Carrier Resuscitation Trial: Scientific Rationale, Study Design, and Results

Oxygen delivery index in homozygous sickle cell disease: steady and crisis states

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