“…Of note, it is not known whether the findings observed in the HOD model will translate to murine RBCs expressing other antigens, or to humans. Human studies investigating the role of RBC storage duration on alloimmunization and other adverse effects have reported varied outcomes ( Dinardo et al, 2015 , Yazer and Triulzi, 2010 , Zalpuri et al, 2013 , Desai et al, 2015 , Koch et al, 2008 , Offner et al, 2002 , Purdy et al, 1997 , Vandromme et al, 2009 , Weinberg et al, 2008 , Zallen et al, 1999 , Fergusson et al, 2012 , Lacroix et al, 2015 , Steiner et al, 2015 ) Future studies are needed in animals and humans, to determine which immune pathways are common or divergent.…”