Transfusion management of Africans with RHD variants in China

Yin, Qinan; Ouchari, Mouna

doi:10.1016/j.tracli.2023.01.003

Cited by 1 publication

(2 citation statements)

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“…This results in four distinct ABO phenotypes: A blood group (I A I A and I A I O ), B blood group (I B I B and I B I O ), AB blood group (I A I B ), and O blood group (I O I O ) [ 2 ]. Rhesus D- (RhD-) positive individuals have genotypes I D I D or I D I d , whereas RhD-negative individuals have the genotype I d I d [ 3 ]. The ABO blood group system is controlled by a single gene at the ABO locus on chromosome 9 at 9q34.1-q34.2.…”

Section: Introductionmentioning

confidence: 99%

“…With numerous blood groups identified in humans to date, the ABO and Rh blood group system holds particular significance in transfusion medicine. At the molecular level, the ABO system exhibits three alleles in the ABO genes, I A , I B , and I O , leading to six potential [3]. The ABO blood group system is controlled by a single gene at the ABO locus on chromosome 9 at 9q34.1-q34.2.…”

Section: Introductionmentioning

confidence: 99%

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Prevalence of ABO and Rhesus (D) Blood Group and Allelic Frequency at Blood Bank of Nigist Eleni Mohammed Hospital, Ethiopia

Lendabo,

Srinivasan,

Rather

2024

BioMed Research International

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Background. The purpose of this cross-sectional study was to determine the pattern of the ABO and rhesus D (RhD) blood group distribution among voluntary blood donors attending five blood donation centers at Nigist Eleni Mohammed General Hospital in Hossana, Ethiopia. Methods. A total of 1,120 participants who fulfilled the “who can give blood” criteria of the World Health Organization were selected randomly. Blood samples were collected, transported to the laboratory, and analyzed for ABO and RhD typing. The data was analyzed using descriptive statistics and chi-square correlation analysis. Results. The study found that the O blood group was the most prevalent (39.0%), followed by A (32.2%), B (22.5%), and AB (6.4%). When considering both the ABO and Rh blood groups together, 92.9% of blood donors were RhD positive, while only 7.1% were RhD negative. The distribution pattern of the ABO blood groups in Gurage Zone, Hadiya Zone, Kembata Zone, and Silte Zone showed that the O blood group was the most prevalent, followed by A, B, and AB, in that order. Conversely, the ABO blood group distribution pattern in Halaba Zone was A > O > B > AB. Civil servants from different occupational statuses were the most dominant voluntary blood donors, accounting for 53.2%, followed by students from different high schools and universities (41.9%), self-employed individuals (4.1%), and others (0.7%). The ABO blood group system had observed allele frequencies significantly different from the expected frequencies (p=0.007), while the RhD system did not (p=0.037). Allele frequencies for A, B, and O in the ABO system were 0.3531, 0.2576, and 0.3893, respectively. Observed frequencies for RhD-positive and RhD-negative alleles were 0.9647 and 0.0531, respectively. Conclusion. This study highlights the regional ABO and RhD blood group variations in Ethiopia, noting disparities from expected ABO allele frequencies, and identifies the O blood group predominance among donors with a high RhD-positive prevalence.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%