Transfusion in Extremely Low-Birth-Weight Premature Neonates: Current Practice Trends, Risks, and Early Interventions to Decrease the Need for Transfusion

Hensch, Lisa; Indrikovs, Alexander J.; Shattuck, Karen E.

doi:10.1542/neo.16-5-e287

Cited by 5 publications

(9 citation statements)

References 59 publications

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“…These prepared suspensions can be used for up to six weeks if they are stored safely. In recent years, donor exposure, transfusion numbers, and the frequency of reactions have markedly decreased with limited transfusion policies, performance of tests for infection, use of leukocyte filters, irradiation, and application of small-volume (10-20 mL/kg) transfusion in VLBW babies (3, 14, 19).…”

Section: Recommendations Related With Erythrocyte Suspension To Be Usmentioning

confidence: 99%

“…Evaluation should be repeated at the end of transfusion and one hour later. Volume loading caused by transfusion should be prevented by subtracting the amount transfused from the total fluid; this is especially important in preterm babies (3, 14, 19).…”

Section: Issues That Should Be Considered In the Application Of Red Bmentioning

confidence: 99%

“…Although it has recently been reported that transfusion-associated necrotizing enterocolitis (TANEC) developing in 48 hours following transfusion may be observed frequently and that mortality is higher in these babies, recent publications related with this issue continue to give contradictory information. It is thought that increased oxygen consumption related with enteral nutrition and nitric oxide-mediated vasodilatation may be responsible from TANEC (5, 19). Similarly, there are reports suggesting that intraventricular hemorrhage (IVH), BPD, and ROP may also be related with transfusion (19).…”

Section: Complications Related With Red Blood Cell Transfusionmentioning

confidence: 99%

“…It is thought that increased oxygen consumption related with enteral nutrition and nitric oxide-mediated vasodilatation may be responsible from TANEC (5, 19). Similarly, there are reports suggesting that intraventricular hemorrhage (IVH), BPD, and ROP may also be related with transfusion (19). Because of all these risks, restrictive transfusion according to threshold Hb values should be preferred with the objective of preventing poor neurologic outcomes.…”

Section: Complications Related With Red Blood Cell Transfusionmentioning

confidence: 99%

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Turkish Neonatal Society guideline on the transfusion principles in newborns

2019

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Blood transfusion can be defined as a life-saving procedure in neonates, especially in premature and surgical infants. The indications, threshold hemoglobin, and platelet levels for red cell, platelet, and plasma transfusions in neonates vary among centers and the evidence-based data for possible adverse effects, preterm morbidities, mortality, and neuro-developmental problems associated with transfusions are not clear yet. Herein, we aim to present the transfusion guideline designed to be used in neonatal intensive care units in our country, summarizing clinical findings and threshold levels for red cell, platelet, and plasma transfusions in addition to important practical points of transfusions according to a literature review.

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Section: Recommendations Related With Erythrocyte Suspension To Be Usmentioning

confidence: 99%

Section: Issues That Should Be Considered In the Application Of Red Bmentioning

confidence: 99%

Section: Complications Related With Red Blood Cell Transfusionmentioning

confidence: 99%

Section: Complications Related With Red Blood Cell Transfusionmentioning

confidence: 99%

See 2 more Smart Citations

Turkish Neonatal Society guideline on the transfusion principles in newborns

2019

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“…Generally, neonates receive RBC transfusions at a dose of 10 to 15 mL/kg (a maximum of 20 mL/kg) for 1 to 2 hours and the transfusion should be completed within 4 hours. It is estimated that the hemoglobin level of the newborn increases by about 2 to 3 g/dL at this dose [ 37 ]. In a multicenter randomized trial for determining whether transfusion of fresh RBCs stored for 7 days or less improved the outcomes in VLBW infants compared with standard-issue RBCs, there were no differences in mortality and major morbidities such as NEC, severe IVH, severe ROP, and BPD between 2 groups.…”

Section: Current Trends and Practices Of Rbc Transfusion In Neonatesmentioning

confidence: 99%

Transfusion practice in neonates

Kim

2018

Korean J Pediatr

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Neonates, especially extremely low birth weight infants, are among the groups of patients undergoing transfusion frequently. Since they are exposed to higher specific transfusion risks compared to the patients of other age groups, there are many special aspects that must be considered for transfusion therapy in neonates. The transfusion risks in neonates include adverse outcomes specific for preterm infants as well as increased metabolic, immunologic, and infectious complications. To reduce the risks of transfusion-transmitted cytomegalovirus infection and transfusion-associated graft-versus-host disease, leukoreduced and irradiated cellular blood products should be used for all neonates. This review summarizes the risks of neonatal transfusion therapy, specific methods to reduce risk, and current trends and practices of red blood cell and platelet transfusions in neonates, to facilitate decision-making for neonatal transfusion.

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Fresh Frozen Plasma and Platelet Transfusion Practices in Neonatal Intensive Care Unit of a Tertiary Care Hospital

Dogra

Kaur

Basu

et al. 2019

Indian J Hematol Blood Transfus

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Blood transfusion is an indispensable part of modern medical and surgical practices. More than 35% of critically ill patients receive transfusion of blood components during their intensive care unit stay. The aim of study is to obtain an information regarding the relationship of platelet concentrate (PC) and fresh frozen plasma (FFP) transfusion on clinical outcome of neonates admitted in neonatal ICU (NICU). This prospective cohort study was conducted from 1st November 2011 to 30th April 2013. The clinical history, blood component details and laboratory parameters were evaluated with clinical outcome. The neonates requiring PC and FFP transfusion were followed up in blood bank for laboratory parameters. Clinical parameters were noted from case file. During the study period, 291 neonates were admitted in NICU. 2 neonates had congenital malformations and thus, were excluded from the study. Of the remaining 289 neonates, 49 neonates received transfusion of platelets and/or FFP. The combined mean donor exposure for all components was found to be 1.48. The mean volume of PC and FFP transfused was 20 ml and 30 ml respectively. The mean pre-and posttransfusion platelet count was 34,000 ll and 42,000 ll respectively. The mean pre-and post-transfusion INR was 2.37 and 1.53 respectively. There was a significant increase in platelet count and decrease in INR in transfused neonates. However, no clinical benefit of PC and FFP transfusion seen on bleeding. Transfusion of PC and FFP has significant effect on laboratory parameters as compared to clinical parameter.

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Transfusion in Extremely Low-Birth-Weight Premature Neonates: Current Practice Trends, Risks, and Early Interventions to Decrease the Need for Transfusion

Cited by 5 publications

References 59 publications

Turkish Neonatal Society guideline on the transfusion principles in newborns

Turkish Neonatal Society guideline on the transfusion principles in newborns

Transfusion practice in neonates

Fresh Frozen Plasma and Platelet Transfusion Practices in Neonatal Intensive Care Unit of a Tertiary Care Hospital

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